Publications by authors named "Ruifang Qi"

An in situ self-cleaning covalent organic framework featuring arylbiguanide arms (Aryl-BIG-COF) was first developed to remove emerging organic pollutants such as propranolol (PRO) from water. The main breakthroughs addressed the scarcity of functional active sites, the impracticality of ex situ regeneration, and the rapid recombination of electronhole pairs in the application of COFs. Owing to the directional capture ability and electronic structure regulation of the arylbiguanide arms, the adsorption capacity and photocatalytic degradation rate of the newly synthesized COF increased by nearly four and seven times, respectively.

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  • Stroke poses a significant health risk, with current treatments lacking effectiveness; elevated NKCC1 expression after a stroke disrupts the blood-brain barrier, contributing to brain swelling.
  • Polygalasaponin F (PGSF), a compound from Polygala japonica, has shown potential neuroprotective effects and could be a therapeutic option for reducing damage after cerebral ischemia-reperfusion injury (CIRI).
  • In experiments, PGSF significantly improved neurological outcomes and reduced NKCC1 expression by enhancing its promoter methylation while also decreasing blood-brain barrier leakage and increasing protective proteins, indicating its promising role in stroke recovery.
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  • Phthalate esters (PAEs) in agricultural soil can harm crop growth and food safety, but research on their behavior and impact is lacking.
  • A study across 106 sites examined 16 PAEs, focusing on how land use, soil conditions, and urbanization influence PAE levels, revealing higher contamination in northern and southern areas.
  • Findings indicated that land type affects PAE concentration, with vegetable fields showing the least contamination, and identified factors like soil pH and microplastic levels as key in determining PAE distribution and potential health risks for both adults and children.
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  • Excessive fluoride exposure in China is linked to nervous system diseases and microglia activation, but the exact mechanism is unclear.
  • This study investigates how sodium fluoride affects inflammation and cell death (pyroptosis) in BV2 microglia using the NLRP3/Caspase-1/GSDMD signaling pathway.
  • Findings show that sodium fluoride damages BV2 cells by disrupting cell membranes and increasing inflammation markers in a dose-dependent manner, while a pyroptosis inhibitor can help mitigate these effects.
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The coexistence of multi-component dissolved organic chemicals causes tremendous challenge in purifying petrochemical wastewater, and stepwise selective adsorption holds the most promise for enhanced treatments. This study is designed to enhance the removal of multiple dissolved organic chemicals by stepwise adsorption. Special attention is given to the selective removal mechanisms for the major pollutant N,N-dimethylformamide (DMF), the sensitive pollutant fluorescent dissolved organic matter (FDOM) and other components.

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Microplastics (MPs) are ubiquitous in agricultural soils, but to what extent and how environmental factors determine the source and fate of MPs in agricultural soils is not clear. In this study, Hainan Island, which has different climatic conditions, altitudes, and land uses across the island, was selected to investigate the MPs abundance and the shape, size, color, and polymer type of the MPs in agricultural soils. The main focus was on the role of land use type and the identification of environmental influencing factors.

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Background: It has been reported that ischemia and ischemic preconditioning (IPC) have different effects on the expression of tuberous sclerosis complex 1 (TSC1), which may contribute to the tolerance to ischemia/hypoxia with the increase of autophagy. The mechanisms of TSC1 differential expression are still unclear under ischemia/IPC conditions in hippocampal Cornu Ammon 1 (CA1) and Cornu Ammon 3 (CA3) area neuronal cells. While we have shown that 5-Aza-CdR, a DNA methyltransferase inhibitor, can upregulate TSC1 and increase hypoxic tolerance by autophagy in vivo and in vitro, in this study, we examined whether DNA methylation was involved in the differential expression of TSC1 in the CA1 and CA3 regions induced by hypoxic preconditioning (HPC).

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Mongolian medical warm acupuncture is a traditional therapy of Mongolian medicine and was developed by people living on the Mongolian Plateau. This kind of traditional oriental medicine has a long history. The main characteristics of Mongolian medical warm acupuncture are the acupoints and the needles used.

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Objective: The present study was designed to compare the changes in ovarian and uterine parameters in girls with idiopathic central precocious puberty (ICPP) before and after gonadotropin-releasing hormone analogues (GnRHa) treatment to determine which sensitive indexes effectively reflect the therapeutic effect.

Methods: Sixty girls diagnosed with ICPP were enrolled in the present study. Relevant data were recorded before treatment.

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Cerebral ischaemia is a common cerebrovascular disease and often induces neuronal apoptosis, leading to brain damage. Polygalasaponin F (PGSF) is one of the components in Polygala japonica Houtt, and it is a triterpenoid saponin monomer. This research focused on anti-apoptotic effect of PGSF during oxygen-glucose deprivation and reoxygenation (OGD/R) injury in rat adrenal pheochromocytoma cells (PC12) and primary rat cortical neurons.

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Objective: To determine the expression levels and clinical significance of serum N-terminal pro-brain natriuretic peptide (NT-proBNP), hydrogen sulfide (H₂S) and interleukin-6 (IL-6) in children with Kawasaki disease (KD).

Study Design: Descriptive comparative study.

Place And Duration Of Study: Department of Pediatric Medicine, Baoding Children's Hospital, from July 2017 to July 2018.

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  • Research indicates that 5-Aza-2'-deoxycytidine (5-Aza-CdR) can enhance hypoxia tolerance by inhibiting protein phosphatase-1γ (PP1γ), which is linked to autophagy and metabolic regulation in brain cells.
  • In tests, 5-Aza-CdR treatment resulted in increased autophagy markers, particularly TSC1 and LC3, and decreased activity of the mTOR pathway, suggesting a shift towards autophagy in response to chronic low oxygen conditions.
  • The findings were confirmed through experiments on mice and cultured neuronal cells, reinforcing the idea that 5-Aza-CdR potentially promotes cellular survival by activating the TSC1/m
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A synthetic protocol for the preparation of an indium oxide nanoparticle-functionalized poly(methacrylic acid-glycidyl methacrylate-ethylene dimethacrylate-ethanediamine) monolithic column is reported. Various techniques, including scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and thermal gravimetric analysis-derivative thermogravimetric analysis were employed to characterize the synthesized monolith. The modified monolithic column was coupled with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) for determining synthetic colorants in various food samples.

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