Surface functionalized biomimetic bioreactors enable the targeted starvation-chemotherapy to glioma.

Altering the glucose supply and the metabolic pathways would be an intriguing strategy in starvation therapy toward cancers. Nevertheless, starvation therapy alone could be inadequate to eliminate tumor cells completely. Herein, a multifunctional bioreactor was fabricated for synergistic starvation-chemotherapy through embedding glucose oxidase (GOx) and doxorubicin (DOX) in the tumor targeting ligands (RGD) modified red blood cell membrane camouflaged metal-organic framework (MOF) nanoparticle (denoted as RGD-mGZD).

Cell membrane camouflaged magnetic nanoparticles as a biomimetic drug discovery platform.

We report a novel biomimetic drug discovery platform using high expression epidermal growth factor receptor (EGFR) HEK 293 cell membrane camouflaged magnetic nanoparticles. The EGFR/magnetic cell membrane nanoparticles (MCMNs) integrated desirable magnetic features and special binding bioaffinity. Application of this drug-targeting concept is expected to pave ways to a new drug discovery strategy.

Crystal structure of 7β-hy-droxy-royleanone isolated from (B.).

The title compound, CHO [systematic name: (4b,8a,10)-3,10-dihy-droxy-2-isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octa-hydro-phenanthrene-1,4-dione], is an abietane-type diterpene, which was isolated from (B.). The compound crystallizes in the chiral space group 2, but it was not possible to determine the absolute structure of the mol-ecule in the crystal by resonant scattering.

Crystal structure of taxodione isolated from (B.).

The title compound [systematic name: (4b)-4-hy-droxy-2-isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a-hexa-hydro-phenanthrene-3,9-dione], CHO, is an abietane-type diterpene, which was isolated from (B.). In the crystal, mol-ecules are linked by weak C-H⋯O hydrogen bonds, forming supra-molecular chains propagating along the [001] direction.