Comparing the clinical characteristics and outcomes of septic shock children with and without malignancies: a retrospective cohort study.

Objective: There is an amelioration in mortality rates of septic shock patients with malignancies over time, but it remains uncertain in children. Therefore, the authors endeavored to compare the clinical characteristics, treatment needs, and outcomes of septic shock children with or without malignancies.

Methods: The authors retrospectively analyzed the data of children admitted to the PICU due to septic shock from January 2015 to December 2022 in a tertiary pediatric hospital.

Relationship between thrombocytopenia and prognosis in children with septic shock: a retrospective cohort study.

Septic shock is a life-threatening disease worldwide often associated with thrombocytopenia. Platelets play a crucial role in bridging the gap between immunity, coagulation, and endothelial cell activation, potentially influencing the course of the disease. However, there are few studies specifically evaluating the impact of thrombocytopenia on the prognosis of pediatric patients.

Protocol for iron-catalyzed cross-electrophile coupling of aryl chlorides with unactivated alkyl chlorides.

Organochlorides are a crucial class of electrophiles in organic synthesis. Here, we present a protocol for the cross-electrophile coupling of aryl chlorides with unactivated alkyl chlorides, facilitated by an iron/Bpin catalytic system. We describe steps for the coupling of aryl chlorides with alkyl chlorides, followed by purification of products.

Inchworm-like Soft Robot with Multi-Responsive Bilayer Films.

As an important branch of robotics, soft robots have the advantages of strong flexibility, a simple structure, and high safety. These characteristics enable soft robots to be widely used in various fields such as biomedicine, military reconnaissance, and micro space exploration. However, contemporary soft crawling robots still face problems such as the single drive mode and complex external equipment.

Symbolic iteration method based on computer algebra analysis for Kepler's equation.

The Kepler's equation of elliptic orbits is one of the most significant fundamental physical equations in Satellite Geodesy. This paper demonstrates symbolic iteration method based on computer algebra analysis (SICAA) to solve the Kepler's equation. The paper presents general symbolic formulas to compute the eccentric anomaly (E) without complex numerical iterative computation at run-time.

Dihydromyricetin alleviates Escherichia coli lipopolysaccharide-induced hepatic injury in chickens by inhibiting the NLRP3 inflammasome.

Dihydromyricetin (DHM), a flavonoid in vine tea, has many pharmacological activities, including anti-inflammatory and antibacterial effects. Lipopolysaccharide is the key inducer of inflammation in avian pathogenic Escherichia coli (E. coli) infection; however, the effect of DHM on E.

A novel Tembusu virus isolated from goslings in China form a new subgenotype 2.1.1.

Since 2010, several duck Tembusu viruses (DTMUVs) have been isolated from infected ducks in China, and these virus strains have undergone extensive variation over the years. Although the infection rate is high, the mortality rate is usually relatively low-~5%-30%; however, since fall 2019, an infectious disease similar to DTMUV infection but with a high mortality rate of ~50% in goslings has been prevalent in Anhui Province, China. The present study identified a new Tembusu virus, designated DTMUV/Goose/China/2019/AQ-19 (AQ-19), that is believed to be responsible for the noticeably high mortality in goslings.

Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway.

Drug-induced liver injury (DILI) is a serious and frequently occurring issue in drug development. The c-Jun N-terminal kinase (JNK) signaling pathway plays an important role in many diseases; hepatocyte nuclear factor-1α (HNF-1α) and glutathione S-transferase A1 (GSTA1) are important in regulating liver-specific genes expressions and affecting drug metabolism. Oltipraz is used to treat liver cirrhosis by improving liver function, and C2-ceramide is a pro-apoptotic lipid that regulates multiple signaling pathways.

Epigallocatechin-3-gallate exhibits antiviral effects against the duck Tembusu virus via blocking virus entry and upregulating type I interferons.

The duck Tembusu virus (DTMUV) is a novel mosquito-borne Flavivirus which caused huge economic losses for poultry industries in Southeast Asia and China. Currently, no effective antiviral drugs against this virus have been reported. (-)-Epigallocatechin-3-gallate (EGCG), a polyphenol present in abundance in green tea, has recently been demonstrated to have an antiviral activity for many viruses; however, whether EGCG can inhibit DTMUV infection remains unknown.

Validation and Diagnostic Performance of a CFD-Based Non-invasive Method for the Diagnosis of Aortic Coarctation.

The clinical diagnosis of aorta coarctation (CoA) constitutes a challenge, which is usually tackled by applying the peak systolic pressure gradient (PSPG) method. Recent advances in computational fluid dynamics (CFD) have suggested that multi-detector computed tomography angiography (MDCTA)-based CFD can serve as a non-invasive PSPG measurement. The aim of this study was to validate a new CFD method that does not require any medical examination data other than MDCTA images for the diagnosis of CoA.

Facile integration of FeS and titanate nanotubes for efficient removal of total Cr from aqueous solution: Synergy in simultaneous reduction of Cr(VI) and adsorption of Cr(III).

In this study, a novel composite composed of iron monosulfide nanoparticles (FeS NPs) and titanate nanotubes (TNTs) was hydrothermally synthesized. Characterizations revealed the encapsulation and homogenous dispersion of FeS NPs into the interlayers of TNTs. Significant performance in removal of aqueous total Cr was acquired by efficient conversion of Cr(VI) to Cr(III) on FeS and simultaneous adsorption of Cr(III) on TNTs.

Pressure-flow curve derived from coronary CT angiography for detection of significant hemodynamic stenosis.

Objectives: Coronary CT angiography (cCTA) has been used to non-invasively assess both the anatomical and hemodynamic significance of coronary stenosis. The current study investigated a new CFD-based method of evaluating pressure-flow curves across a stenosis to further enhance the diagnostic value of cCTA imaging.

Methods: Fifty-eight patients who underwent both cCTA imaging and invasive coronary angiography (ICA) with fractional flow reserve (FFR) within 2 weeks were enrolled.

Araneose Ti self-doping TiO/SiO nanowires membrane for removal of aqueous MB under visible light irradiation.

Araneose Ti self-doped TiO/SiO nanowires (RTiO/SiO) were prepared and anchored onto a polyethersulfone (PES) membrane. Careful characterizations and measurements indicated a covalent grafting of SiO onto reduced TiO (RTiO) through Ti-O-Si linkages, acquiring uniformed RTiO/SiO nanowires of almost complete anatase and benign hydrophilicity. The RTiO/SiO-based PES membrane showed a significantly enhanced visible light-driven degradation rate of methylene blue (MB) (90.

Tributyltin disrupts feeding and energy metabolism in the goldfish (Carassius auratus).

Tributyltin (TBT) can induce obesogen response. However, little is known about the adverse effects of TBT on food intake and energy metabolism. The present study was designed to investigate the effects of TBT, at environmental concentrations of 2.

Label-Free DNA Sequence Detection through FRET from a Fluorescent Polymer with Pyrene Excimer to SG.

A label-free complex probe composed of a water-soluble fluorescent pyrene-functionalized polymer, ssDNA, and a nucleic acid stain (SG) is presented here, which can detect DNA sequence via FRET from pyrene excimer to SG. Complementary and one-base mismatched strands at nanomolar concentrations can be distinguished by the examination of the FRET fluorescence intensity of SG. This novel strategy for detecting DNA using the fluorescent pyrene-functionalized polymer not only affords a simple label-free method to detect nucleic acid sequence but also endows the detection with high sensitivity and selectivity, which may find wide applications for optical biosensing.

Fluorescence detection of DNA hybridization based on the aggregation-induced emission of a perylene-functionalized polymer.

A perylene-functionalized polycation was synthesized by quaternization of poly(4-vinylpyridine) with bromomethyl-perylene and methyl iodide, which exhibited a unique aggregation-induced emission (AIE) effect. The synthesized polycation and polyanion ssDNA could form a complex probe to detect DNA hybridization. Upon adding noncomplementary ssDNA, the fluorescence of the complex probe increased due to the AIE effect; upon adding complementary ssDNA, the fluorescence intensity changed little due to the combined effects of AIE and duplex-quenching resulting from the intercalation of perylene into the duplex.

Polymer nanoparticles for controlled release stimulated by visible light and pH.

Polymer nanoparticles are prepared by self-assembly of visible light and pH sensitive perylene-functionalized copolymers which are synthesized by quaternization between 1-(bromomethyl)perylene and the dimethylaminoethyl units of poly(dimethylaminoethyl methacrylate) (PDMAEMA). The perylene-containing polymethacrylate segments afford the system visible light responsiveness and the unquaternized PDMAEMA segments afford the system pH responsiveness. The self-assembled nanoparticles exhibit a unique dual stimuli response.

[Study on the hepatoxicity of polygoni multiflori radix and polygoni multiflori rodix praeparata in rats].

Objective: To compare the hepatoxicity of Polygoni Multiflori Radix and Polygoni Multiflori Rodix Praeparata in rats.

Methods: Water extracts of Polygoni Multiflori Radix and Polygoni Multiflori Rodix Praeparata were prepared by concentional decocting method (named as RPWE and PPWE respectively). Both in 30 days and 60 days experiments, SD rats were randomly divided into 5 groups: normal control group, RPWE high dosage group (40 mg/kg x d) and PPWE low dosage group (20 mg/kg x d), PPWE high dosage group (40 mg/kg x d) and PPEW low dosage group (20 mg/kg x d).

Synthesis and fluorescence study of a quaternized copolymer containing pyrene for DNA-hybridization detection.

Built-in detector: A quaternized copolymer containing pyrene is described, which can bind to single-stranded DNA by electrostatic interactions to form a novel complex probe for the detection of DNA hybridization through strengthened fluorescence quenching through its intercalation into double-stranded DNA (see figure).

[Damage effect of Polygonum multiflorum fractions on human normal liver cells L02 and liver cancer cells HepG2].

Objective: To investigate the damage effect of different fractions from Polygonum multiflorum on normal human liver and liver cancer cells, in order to seek for fractions that can obviously kill cancer cells but have less impact on normal liver cells, and make a preliminary study on different mechanism of the two kinds of cells.

Method: P. multiflorum water-eluted fraction (RW), 50% ethanol-eluted fraction (R50) and 95% ethanol-eluted fraction (R95) were successively obtained from 70% ethanol extracts of P.

[Effects of extract of Polygonum multiflorum on cell cycle arrest and apoptosis of human liver cell line L02].

Objective: To analyze the chemical constituents of Polygonum multiflorum extract which may cause human liver cell damage and to explore the mechanism.

Methods: Raw and processed Polygonum multiflorum were extracted by 70% ethanol, then raw and processed Polygonum multiflorum water-eluted material (RW and PW), 50% ethanol-eluted material (R50 and P50) and 95% ethanol-eluted material (R95 and P95) were obtained by absorbing through AB-8 macroporous resin, followed by water, 50% ethanol and 95% ethanol elution in order. The water extracts of raw and processed Polygonum multiflorum (RWE or PWE) were obtained by boiling them in water as usual.