Publications by authors named "Ruichao Huang"
In all mammals, the basement membrane serves as a pivotal extracellular matrix. Hepatocellular carcinoma (HCC) is a challenge among numerous cancer types shaped by basement membrane-related genes (BMGs). Our research established an innovative prognostic model that is highly accurate in its prediction of HCC prognoses and immunotherapy efficacy to summarize the crucial role of BMGs in HCC.
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- Polyetheretherketone (PEEK) implants face challenges with soft tissue integration, leading to complications that hinder their effectiveness in craniomaxillofacial bone repair.
- This study introduces 3D printed, multi-stage microporous PEEK implants coated with basic fibroblast growth factor (bFGF) using polydopamine to improve soft tissue integration.
- The results showed that these bFGF/polydopamine-loaded PEEK implants enhanced cell growth and adhesion while activating important signaling pathways, suggesting a promising approach for better clinical applications in the future.
Osteosarcoma (OS) is a kind of solid tumor with high heterogeneity at tumor microenvironment (TME), genome and transcriptome level. In view of the regulatory effect of metabolism on TME, this study was based on four metabolic models to explore the intertumoral heterogeneity of OS at the RNA sequencing (RNA-seq) level and the intratumoral heterogeneity of OS at the bulk RNA-seq and single cell RNA-seq (scRNA-seq) level. The GSVA package was used for single-sample gene set enrichment analysis (ssGSEA) analysis to obtain a glycolysis, pentose phosphate pathway (PPP), fatty acid oxidation (FAO) and glutaminolysis gene sets score.
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