Retrograde approach for recanalization in stumpless chronic total occlusion: A case report.

Chronic total occlusive disease of the coronary arteries is the most challenging disease in the field of coronary intervention. When the anterograde approach is not feasible, the retrograde approach remains the only strategy.

Risk factors associated with hospital mortality in non-surgical patients receiving extracorporeal membrane oxygenation and continuous renal replacement treatment: a retrospective analysis.

Objectives: The prognosis-predicting factors for non-surgical patients receiving continuous renal replacement therapy (CRRT) and extracorporeal membrane oxygenation (ECMO) remains limited. In this study, we aim to analyze prognosis-predicting factors in the non-surgical patients receiving these two therapies.

Methods: We retrospectively analyzed data from non-surgical patients with ECMO treatment from December 2013 until April 2023.

Downregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis.

Background: Macrophage-derived extracellular vesicle (macrophage-EV) is highly studied for its regulatory role in atherosclerosis (AS). Our current study tried to elucidate the possible role of macrophage-EV loaded with small interfering RNA against high-mobility group box 1 (siHMGB1) affecting atherosclerotic plaque formation.

Methods: In silico analysis was performed to find critical factors in mouse atherosclerotic plaque formation.

L1 cell adhesion molecule may be a protective molecule for atrial fibrillation in patients with valvular heart disease.

Background: Atrial fibrillation (AF) is the most prevalent sustained arrhythmia. L1 cell adhesion molecule (L1CAM) served as a crucial regulator of signaling pathways. This research sought to examine the clinical value and functions of soluble L1CAM in the serum of AF patients.

Noncoding RNA in the Regulation of Acute Aortic Dissection: From Profile to Mechanism.

Aortic dissection is a life-threatening condition caused by a tear in the intimal layer of the aorta or bleeding within the aortic wall, resulting in the separation of the layers of the aortic wall. As Nienaber reported, aortic dissection is most common in people 65-75 years old and has an incidence of 35 cases per 100,000 people per year in this population. Many pathogenic factors are involved in aortic dissection, including hypertension, dyslipidemia, and abnormality of the aortic intima caused by genetic variation.

Relationship of pulse pressure index and carotid intima-media thickness in hypertensive adults.

Objective: To evaluate the relationship between pulse pressure index (PPI) and carotid intima-media thickness (CIMT).

Method: Observational trial was design and 342 patients newly diagnosed as hypertension without anti-hypertensive therapy were enrolled. According to the cut-off value of CIMT, 342 participants were divided into normal (< 0.