Geographical origins of Angelica sinensis using functional compounds and multielement with machine learning-based fusion approaches.

Ensuring food traceability is essential for maintaining safety and authenticity. Angelica sinensis (Oliv.) Diels (AS), a medicinal food prized for its rich nutritional value and tonic effects, is frequently vulnerable to geographic origin fraud.

[Chemical constituents from petroleum ether fraction of Artemisia stolonifera].

The chemical constituents in the petroleum ether fraction of Artemisia stolonifera were investigated. Twenty compounds(1-20) were isolated from the petroleum ether fraction of A. stolonifera by silica gel, Sephadex LH-20, and ODS chromatography and semi-preparative HPLC.

[Geographical origin authentication of Gongju at different spatial scales based on hyperspectral technology].

Gongju(Chrysanthemum morifolium) is one of the five major medicinal Chrysanthemum varieties included in the Chinese Pharmacopoeia. In recent years, its cultivation areas have changed significantly, resulting in mixed quality of the medicinal herbs. In this study, Gongju cultivated in Anhui, Yunnan, Chongqing, and other places were selected as research objects.

Tanshinone Content Prediction and Geographical Origin Classification of by Combining Hyperspectral Imaging with Chemometrics.

Hyperspectral imaging (HSI) technology was combined with chemometrics to achieve rapid determination of tanshinone contents in , as well as the rapid identification of its origins. Derivative (D1), second derivative (D2), Savitzky-Golay filtering (SG), multiplicative scatter correction (MSC), and standard normal variate transformation (SNV) were utilized to preprocess original spectrum (ORI). Partial least squares discriminant analysis (PLS-DA) and support vector machine (SVM) models were employed to discriminate 420 samples collected from Shandong, Hebei, Shanxi, Sichuan, and Anhui Provinces.

Rapid qualitative and quantitative detection for adulteration of Atractylodis Rhizoma using hyperspectral imaging combined with chemometric methods.

In the field of traditional Chinese medicine, Atractylodis Rhizoma (AR) is commonly used for various diseases due to its excellent ability to dry dampness and strengthen the spleen, especially popular in East Asia. The aim of this study is to proposed Hyperspectral Imaging (HSI) in combination with chemometric methods for the rapid qualitative and quantitative detection of AR adulteration with other types of powder. Partial Least Squares Discriminant Analysis (PLS-DA) was used to construct the classification models the best, with the First-order Derivative (F-D) preprocessing method.

Anti-inflammatory mechanism of Houttuynia cordata polysaccharides against ulcerative colitis based on multi-omics conjoint analysis.

The Houttuynia cordata polysaccharide (HCP) was extracted from the traditional Chinese medicine, Houttuynia cordata, known for its anti-inflammatory properties. It has an acidic heteropolysaccharide with a molecular weight of approximately 13.38 kDa, consisting of 7 monosaccharides such as galactose, galacturonic acid, and glucose.

Identification and Classification of Storage Years Based on Hyperspectral Imaging Technology Combined with Deep Learning.

Developing a fast and non-destructive methodology to identify the storage years of is important in safeguarding consumer well-being. This study employed the utilization of hyperspectral imaging (HSI) in conjunction with conventional machine learning techniques such as support vector machines (SVM), k-nearest neighbors (KNN), random forest (RF), extreme gradient boosting (XGBoost), as well as the deep learning method of residual neural network (ResNet), to establish identification models for samples from different storage years. Under the fusion-based modeling approach, the model's classification accuracy surpasses that of visible to near infrared (VNIR) and short-wave infrared (SWIR) spectral modeling individually.

Geographical verification of Pleuropterus multiflorus thunb. by functional compounds, stable isotope ratios, and multielement combined with machine learning methods.

The dry roots of Pleuropterus multiflorus Thunb. (PM) have been traditionally utilized as functional foods and medicines China and various Asian countries. They are extensively cultivated in multiple provinces in China, with variations in prices and qualities.

Prediction performance and reliability evaluation of three ginsenosides in Panax ginseng using hyperspectral imaging combined with a novel ensemble chemometric model.

Panax ginseng C. A. Meyer (PG) is a health-promoting food, and its ginsenosides (Rb1, Rg1, Re) content, as the quality indicator, is affected by the planting modes (garden or forest ginsengs) and years.

Structural Priors Guided Network for the Corneal Endothelial Cell Segmentation.

The segmentation of blurred cell boundaries in cornea endothelium microscope images is challenging, which affects the clinical parameter estimation accuracy. Existing deep learning methods only consider pixel-wise classification accuracy and lack of utilization of cell structure knowledge. Therefore, the segmentation of the blurred cell boundary is discontinuous.

LC-MS/MS-Guided Molecular Networking for Targeted Discovery of Undescribed and Bioactive Ophiobolins from .

An integrated purification procedure through the LC-MS/MS-based molecular networking strategy combined with bioactive evaluation was first ushered for discovering bioactive ophiobolins from . Ophiobolins were mainly dispersed in five clusters, which were classified based on different ring systems and functional groups. Nine undescribed ophiobolins (- and -) and an undescribed natural product () along with two known analogs ( and ) were isolated in target.

[Research progress of Codonopsis Radix and prediction of its Q-markers].

Codonopsis Radix is a traditional tonic medicine commonly used in China, which has the effects of strengthening the spleen and tonifying the lung, as well as nourishing blood and engendering liquid. The chemical constituents of Codonopsis species are mainly polyacetylenes, alkaloids, phenylpropanoids, lignans, terpenoids and saponins, flavonoids, steroids, organic acids, saccharides, and so on. Modern pharmacological studies showed that Codonopsis Radix also has a variety of pharmacological effects such as enhancing body immunity, protecting gastrointestinal mucosa and resisting ulcers, promoting hematopoietic function, regulating blood sugar, and delaying aging.

Storage strategy of outbound containers with uncertain weight by data-driven hybrid genetic simulated annealing algorithm.

It is necessary to ensure the ship's stability in container ship stowage and loading and unloading containers. This work aims to reduce the container dumping operation at the midway port and improve the efficiency of ship transportation. Firstly, the constraint problem of the traditional container ship stacking is introduced to realize the multi-condition mathematical model of the container ship, container, and wharf.

Protective effect of on gentamicin-induced nephrotoxicity in rats.

Objective: Gentamicin (GM) is a commonly used aminoglycoside antibiotic, however, renal toxicity has limited its usage. The present study was designed to evaluate the ameliorative effect of on GM-induced nephrotoxicity in rats.

Methods: The nephrotoxicity in rats was induced by intraperitoneal administration of GM (100 mg/kg) for 10 consecutive days.

Discrimination of three varieties of Codonopsis Radix based on fingerprint profiles of oligosaccharides by high performance liquid chromatography- evaporative light scattering detector combined with multivariate analysis.

Codonopsis Radix (CR) is a plant that is important in the practice of traditional Chinese medicine (TCM). The Chinese Pharmacopoeia 2020 records dried roots prepared from three varieties of Campanulaceae plants under the designation CR ("Dang-shen" in Chinese), including Codonopsis pilosula (Franch.) Nannf (C.

oligosaccharides modulate the gut microbiota and change serum metabolomic profiles in high-fat diet-induced obese mice.

Obesity has become a major health problem worldwide, linked to gut microbiota imbalance and chronic inflammation. This study aims to evaluate whether oligosaccharides (CPOs) can alleviate obesity and related metabolic complications in high-fat diet (HFD) induced obese mice. Male C57BL/6J mice were fed with a HFD for 16 weeks and treated daily with CPOs (500 mg kg).

Intra-regional classification of Codonopsis Radix produced in Gansu province (China) by multi-elemental analysis and chemometric tools.

Multi-elemental analysis is widely used to identify the geographical origins of plants. The purpose of this study was to explore the feasibility of combining chemometrics with multi-element analysis for classification of Codonopsis Radix from different producing regions of Gansu province (China). A total of 117 Codonopsis Radix samples from 7 counties of Gansu province were collected.

A monitoring survey and health risk assessment for pesticide residues on Codonopsis Radix in China.

In recent years, the safety of Codonopsis Radix (CR) has attracted considerable attention. Pesticide residues is an important index to evaluate the safety of CR. The purpose of this study was to monitor pesticide residues in 164 batches of CR in China and assess dietary risk assessment.

Analysis and Health Risk Assessment of Potentially Toxic Elements in Three Codonopsis Radix Varieties in China.

As a valuable medicine food homology plant, Codonopsis Radix has been widely used in China. This study aimed to analyze the content of nine potentially toxic elements in three Codonopsis Radix varieties and evaluate their health risks to the human body. In this study, a total of 147 samples were collected from five provinces in China.

Immune-enhancement effects of oligosaccharides from Codonopsis pilosula on cyclophosphamide induced immunosuppression in mice.

As an important edible traditional Chinese medicine, Codonopsis pilosula has good immunomodulation effects. This study focuses on C. pilosula oligosaccharides (CPO), which are the sweetness components of C.

Cytotoxicity of two water-soluble polysaccharides from Codonopsis pilosula Nannf. var. modesta (Nannf.) L.T.Shen against human hepatocellular carcinoma HepG2 cells and its mechanism.

Two water-soluble polysaccharides named CPP1a and CPP1c were isolated from C. pilosula Nannf. var.

Structural characterization of a pectic polysaccharide from Codonopsis pilosula and its immunomodulatory activities in vivo and in vitro.

A pectic polysaccharide (named as CPP1c) extracted from Codonopsis pilosula was evaluated for its structural features and potential of immune-modulating activities in an aging mouse model of senescence accelerated mouse prone 8 (SAMP8) in vitro and in vivo. The relative molecular weight and the absolute molecular weight of CPP1c were 1.26×10Da and 1.

Direct electrochemistry and electrocatalysis of lobetyolin via magnetic functionalized reduced graphene oxide film fabricated electrochemical sensor.

A novel lobetyolin electrochemical sensor based on a magnetic functionalized reduced graphene oxide/Nafion nanohybrid film has been introduced in this work. The magnetic functionalized reduced graphene oxide was characterized by fourier transform infrared spectroscopy, atomic force microscope, X-ray diffraction, transmission electron microscopy and thermogravimetric analysis. The scanning electron microscopy characterized the morphology and microstructure of the prepared sensors, and the electrochemical effective surface areas of the prepared sensors were also calculated by chronocoulometry method.

A Theoretical and Empirical Integrated Method to Select the Optimal Combined Signals for Geometry-Free and Geometry-Based Three-Carrier Ambiguity Resolution.

Twelve GPS Block IIF satellites, out of the current constellation, can transmit on three-frequency signals (L1, L2, L5). Taking advantages of these signals, Three-Carrier Ambiguity Resolution (TCAR) is expected to bring much benefit for ambiguity resolution. One of the research areas is to find the optimal combined signals for a better ambiguity resolution in geometry-free (GF) and geometry-based (GB) mode.

Investigate electrochemical immunosensor of cortisol based on gold nanoparticles/magnetic functionalized reduced graphene oxide.

A sensitively competitive electrochemical immunosensor for the detection of cortisol was successfully developed based on gold nanoparticles and magnetic functionalized reduced graphene oxide (AuNPs/MrGO). In order to construct the base of the immunosensor, the MrGO was initially fabricated by chemical cross-linking and used to modify the nafion pretreated glassy carbon electrode. Subsequently, the surface of electrode was modified by AuNPs via electrochemical deposition.