Pharmacokinetic/Pharmacodynamic (PK/PD) Profiles of Tulathromycin in an Experimental Intraperitoneal Infection Model in Neutropenic Guinea Pigs.

Tulathromycin is a semi-synthetic macrolide antimicrobial that has an important role in veterinary medicine for respiratory disease. The objective of the study was to develop a pharmacokinetic/pharmacodynamic (PK/PD) model to examine the efficacy and determine an optimal dosage of tulathromycin intramuscular (IM) treatment against infection induced after intraperitoneal inoculation in neutropenic guinea pigs. The PKs of tulathromycin in serum and lung tissue after intramuscular administration at doses of 1, 10, and 20 mg/kg in -infected neutropenic guinea pigs were evaluated by liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Characterization of antimicrobial resistance and virulence genes of Pseudomonas aeruginosa isolated from mink in China, 2011-2020.

Pseudomonas aeruginosa strains are potential pathogens that cause respiratory diseases in minks, and caused serious economic loss to mink breeding industry. In this study, we identified antimicrobial resistance and virulence genes in 125 P. aeruginosa isolates from mink in China from 2011 to 2020.

ModuleNet: Knowledge-Inherited Neural Architecture Search.

Although neural the architecture search (NAS) can bring improvement to deep models, it always neglects precious knowledge of existing models. The computation and time costing property in NAS also means that we should not start from scratch to search, but make every attempt to reuse the existing knowledge. In this article, we discuss what kind of knowledge in a model can and should be used for a new architecture design.

Does Serum Uric Acid Status Influence the Association Between Left Atrium Diameter and Atrial Fibrillation in Hypertension Patients?

Both serum uric acid (SUA) levels and left atrium diameter (LAD) associate with AF. However, the influence of SUA status for the associated risk of AF related to LAD in hypertension patients is currently unknown. We retrospectively analyzed a hospital-based sample of 9,618 hypertension patients.

Boost 3-D Object Detection via Point Clouds Segmentation and Fused 3-D GIoU-L₁ Loss.

The 3-D object detection is crucial for many real-world applications, attracting many researchers' attention. Beyond 2-D object detection, 3-D object detection usually needs to extract appearance, depth, position, and orientation information from light detection and ranging (LiDAR) and camera sensors. However, due to more degrees of freedom and vertices, existing detection methods that directly transform from 2-D to 3-D still face several challenges, such as exploding increase of anchors' number and inefficient or hard-to-optimize objective.

Cancer patients with potential eligibility for vascular endothelial growth factor antagonists use have an increased risk for cardiovascular diseases comorbidities.

Background: Recent studies have reported the prevalence of cardiovascular diseases (CVDs) among cancer patients following the use of the vascular endothelial growth factor (VEGF) signaling inhibitors. However, data for patients with a history of cancer before active cancer treatment are lacking. This study aims to investigate the distribution of CVD-related comorbidities before cancer treatment in potential VEGF antagonists candidates.