A Dual-Mode Colorimetric and Fluorescence Biosensor Based on a Nucleic Acid Multiplexing Platform for the Detection of .

() is one of the most prevalent threats, capable of inducing diverse illnesses and presenting a serious threat to public health. Herein, we demonstrate a novel dual-mode colorimetric/fluorescence biosensor based on the xponential mplification reaction and trand isplacement eactions (EASDR), which has multiplexing capability that significantly promotes the anchoring and trapping of Pt nanoparticles (Pt NPs) and fluorescent dyes for sensitive detection of (). The method works by targeting specific bacteria with aptamers and promoting repeated EASDR to affect the immobilization of Pt NPs and fluorescent dyes in the orifice plate, which could produce changes in fluorescence and colorimetric signals.

Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells.

Objective: Dysregulation of chondrogenic differentiation is associated with osteoarthritis (OA). The myokine irisin is beneficial in OA treatment; yet, the underlying mechanism is not fully understood. Long noncoding RNAs (lncRNAs) act as important regulators of chondrocyte differentiation.

Dominant Charge Density Order in TaTe_{4}.

Electronic orders such as charge density wave (CDW) and superconductivity raise exotic physics and phenomena as evidenced in recently discovered kagome superconductors and transition metal chalcogenides. In most materials, CDW induces a weak, perturbative effect, manifested as shadow bands, minigaps, resistivity kinks, etc. Here we demonstrate a unique example-transition metal tetratellurides TaTe_{4}, in which the CDW order dominates the electronic structure and transport properties.

Generation of advanced glycation end products from glycated protein or fructose/glyoxal-protein adducts under in vitro simulated gastrointestinal digestion.

Advanced glycation end products (AGEs) are a heterogeneous group of compounds formed both endogenously and exogenously through reactions between reducing sugars and amino acids within the proteins. The digestive tract may also serve as a site for endogenous AGEs generation. This study examined whether additional AGEs are formed during the digestion of glycated protein diets and meal-resembling systems (dietary proteins with fructose or glyoxal).

Crystal Growth, Structure, and Diverse Magnetic Behaviors in Frustrated Triangular Lattice REBO (RE = Tb-Yb).

Triangular lattice (TL) materials are a rich playground for investigating exotic quantum spin states and related applications in quantum computing and quantum information. Millimeter-level single crystals of REBO (RE = Tb-Yb) with a nearly perfect RE-based TL have been successfully grown via a high-temperature flux method and structurally characterized via single-crystal X-ray diffraction. These 113-type materials crystallize in a monoclinic crystal system with a 2/ space group.

Ecological risks of high-ammonia environment with inhibited growth of Daphnia magna: Disturbed energy metabolism and oxidative stress.

High ammonia pollution is a common problem in water bodies. However, research on the mechanisms underlying the toxic effects on organisms at different nutritional levels is still insufficient. Herein, based on the environmental concentration, the toxic effects of high ammonia pollution on Daphnia magna were investigated.

Synthesis, Structure, and Magnetic Properties of Cyanurates (CNO)(OH) ( = Gd-Lu): Cryogenic Magnetocaloric Candidate Gd(CNO)(OH).

Rare-earth ()-based frustrated magnets are fertile playgrounds for discovering exotic quantum phenomena and exploring adiabatic demagnetization refrigeration applications. Here, we report the synthesis, structure, and magnetic properties of a family of rare-earth cyanurates (CNO)(OH) ( = Gd-Lu) with an acentric space group 6̅2. Magnetic susceptibility χ() and isothermal magnetization () measurements manifest that (CNO)(OH) ( = Gd, Dy-Yb) compounds exhibit no magnetic ordering down to 2 K, while Tb(CNO)(OH) shows long-range magnetic ordering around 3.

Stabilization of Short- and Long-Range Magnetic Ordering through the Cooperative Effect of 1D [CuO] Chains and [CuOX] Quadrilateral in Quasi-1D Spin-1/2 Systems.

Quasi-1D chain antiferromagnets with reduced structural dimensionality are a rich playground for investigating novel quantum phenomena. We report the synthesis, crystal structure, and magnetism of two novel quasi-1D antiferromagnets, β-PbCu(TeO)Cl (I) and PbCu(TeO)Br (II). Their magnetic frameworks are constructed via Cu-based quasi-1D [Cu(2)O] zigzag chains with square-planar [Cu(1)OX] (X=Cl or Br) separated among 1D chains.

17β-estradiol promotes myeloid-derived suppressor cells functions and alleviates inflammatory bowel disease by activation of Stat3 and NF-κB signalings.

Inflammatory bowel disease (IBD) describes a group of clinically common autoimmune diseases characterized by chronic intestinal inflammation, with gender differences in prevalence. Estrogen has been previously shown to exert anti-inflammatory action in IBD development, however, the mechanisms remain obscure. Recent research has revealed that myeloid-derived suppressor cells (MDSCs) play a protective role in IBD pathogenesis.

Migration and transformation behaviors of antibiotics in water-sediment system under simulated light and wind waves.

Antibiotics can generally be detected in the water-sediment systems of lakes. However, research on the migration and transformation of antibiotics in water-sediment systems based on the influences of light and wind waves is minimal. To address this research gap, we investigated the specific impacts of light and wind waves on the migration and transformation of three antibiotics, norfloxacin (NOR), trimethoprim (TMP), and sulfamethoxazole (SMX), under simulated light and wind waves disturbance conditions in a water-sediment system from Taihu Lake, China.

Follicle-stimulating hormone accelerates osteoclast migration by enhancing methyltransferase-like 3-mediated m6A methylation of cathepsin K.

Follicle-stimulating hormone (FSH) accelerates osteoporosis in postmenopausal women, while the underlying mechanism remains uncharacterized. N6-methyladenosine (m6A) is one of the most important regulations in the development of osteoporosis. In this study, we aimed to investigate the role of FSH in m6A modification and osteoclast function.

Superconductivity in the High-Entropy Ceramics Ti Zr Nb Mo Ta C with Possible Nontrivial Band Topology.

Topological superconductors have drawn significant interest from the scientific community due to the accompanying Majorana fermions. Here, the discovery of electronic structure and superconductivity (SC) in high-entropy ceramics Ti Zr Nb Mo Ta C (x = 1 and 0.8) combined with experiments and first-principles calculations is reported.

Toxicity of TPhP on the gills and intestines of zebrafish from the perspectives of histopathology, oxidative stress and immune response.

As an organophosphate ester (OPE), triphenyl phosphate (TPhP) has been frequently detected in aquatic environments, and its environmental risk has been widely studied. The gills and intestines are the most important part of the mucosal immune barrier in fish as the first line of defense against the invasion of harmful substances. TPhP is more abundant in the gill and intestine of fish.

Influence by varying organic matter content and forms in suspended particulate matter: impacts on the adsorption of tetracycline and norfloxacin.

Antibiotics are commonly detected in natural waters. The organic matter (OM) in suspended particulate matter (SPM) has a critical impact on the adsorption of antibiotics in water. We investigated the contribution of OM content and form to the adsorption of tetracycline (TC) and norfloxacin (NOR) in the SPM of Taihu Lake.

Improvement on Magnetocaloric Effect through Structural Evolution in Gadolinium Borate Halides BaGd(BO)X (X = F, Cl).

A new Gd-containing borate BaGd(BO)F has been successfully grown via the high-temperature solution method using BaF-NaF-BO flux. BaGd(BO)F crystallizing in the orthorhombic space group is with lattice parameters = 7.571(4) Å, = 10.

Carbon quantum dot-induced developmental toxicity in Daphnia magna involves disturbance of symbiotic microorganisms.

With the increasing synthesis and application of carbon quantum dots (CQDs), their prevalence as pollution in water environments has increased. However, the toxic effects of CQDs on aquatic organisms are unclear, and their environmental safety must be evaluated. Herein, Daphnia magna was used as a model organism to explore the developmental toxicity of CQDs under a full life-cycle exposure.

Developmental toxicity in Daphnia magna induced by environmentally relevant concentrations of carbon black: From the perspective of metabolomics and symbiotic bacteria composition.

The level of carbon black (CB) pollution in the environment is rapidly increasing, owing to the increase in natural and industrial emissions. The water environment has become an important sink for CB. However, studies on CB mainly focused on its impact on air pollution and phytoremediation applications, and the toxicity mechanism of CB in aquatic organisms is relatively limited.

Radical oxygen species: an important breakthrough point for botanical drugs to regulate oxidative stress and treat the disorder of glycolipid metabolism.

The incidence of glycolipid metabolic diseases is extremely high worldwide, which greatly hinders people's life expectancy and patients' quality of life. Oxidative stress (OS) aggravates the development of diseases in glycolipid metabolism. Radical oxygen species (ROS) is a key factor in the signal transduction of OS, which can regulate cell apoptosis and contribute to inflammation.

Two non-centrosymmetric mixed alkali metal and alkaline earth metal scandium borate nonlinear optical materials with short ultraviolet cutoff edges.

Rare earth borates, a subset of the essential nonlinear optical (NLO) materials, have sparked a significant amount of attention in recent years. In self-fluxing systems, two non-centrosymmetric scandium borates with classical BO groups, namely RbSrScBO (I) and RbCaScBO (II), were successfully discovered. Both I and II exhibit a short ultraviolet (UV) cutoff edge (<200 nm) and appropriate second-harmonic generation efficiency (∼0.

BaPbBe(BO)F: The First Pb-Containing Beryllium Borate Fluoride with Trigonal Prismatic PbO and 2D [BeBOF] Layers.

BaPbBe(BO)F (BPBBF), a previously unreported lead-containing beryllium borate fluoride, has been successfully grown through a high-temperature flux method. Its structure is solved by single-crystal X-ray diffraction (SC-XRD), and it is optically characterized via infrared, Raman, UV-vis-IR transmission, and polarizing spectra as well. SC-XRD data suggests that it can be indexed by a trigonal unit cell (space group 31) with lattice parameters = 4.

The effect of OSA on the negative pressure and acoustic compliance of middle ear cavity in children.

Objective: To explore the effect of obstructive sleep apnea (OSA) on the negative pressure and acoustic compliance of middle ear cavity in children.

Methods: The clinical data of 258 children with suspected OSA, who complained of mouth breathing or snoring at night in the Department of Otolaryngology Head and neck surgery of the Second Affiliated Hospital of Xi'an Jiao Tong University from August 2020 to March 2022, were enrolled and analyzed retrospectively. The OSA and otitis media with effusion (OME) were determined by polysomnography (PSG) and acoustic immittance examination, respectively.