Publications by authors named "RuiXiang Chen"

BrSWEET11 accelerated Arabidopsis thaliana flowering, while silencing Brsweet11 in Brassica rapa delayed flowering relative to controls. BrSWEET11 is involved in sucrose transport after being induced by long-day conditions. SWEETs (Sugars Will Eventually Be Exported Transporters) are sugar outflow transporters that may participate in the regulation of plant flowering.

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  • The study aimed to evaluate the effectiveness of acupuncture combined with standard treatment in improving outcomes for osteoporosis patients over 6 months.
  • Participants were split into a control group receiving only standard treatment (calcium and vitamin D3) and an acupuncture group receiving both standard treatment and acupuncture.
  • Results showed that the acupuncture group had significantly better balance scores and improvements in muscle strength, while certain bone density measurements showed improvement compared to pre-treatment levels, though not significantly different from the control group.
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  • The study investigates the role of Terf2ip in non-alcoholic steatohepatitis (NASH) after previous research found its importance in liver injury.
  • Researchers found that Terf2ip levels were significantly lower in the livers of NASH patients and in mouse models, leading to worsened liver fat accumulation and impaired fat processing.
  • The findings suggest that Terf2ip helps protect against NASH by influencing the Sirt1/AMPK pathway, and potentially offers a new target for NASH treatment.
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Background: Protein-1 (PD-1) and programmed cell death 1 ligand 1 (PD-L1) therapy have become an important treatment approach for patients with advanced nonsmall cell lung cancer (NSCLC), but primary or secondary resistance remains a challenge for some patients. PD-1/PD-L1 combined with anti-angiogenic drugs (AAs) in NSCLC patients have potential synergistic effects, and the survival benefit may vary based on a treatment order. To investigate the efficacy of PD-1/PD-L1 combined with AAs as the treatment for patients with advanced NSCLC.

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  • Deubiquitylating enzymes (DUBs) are crucial for protein degradation and show promise as cancer therapies, but their role in cholangiocarcinoma (CCA) is not well studied.
  • Research revealed that USP21, a specific DUB, is overexpressed in CCA and correlates with poorer patient outcomes, playing a key role in tumor growth and maintenance.
  • USP21 stabilizes proteins like HSP90 and ENO1, enhancing glycolysis and promoting cell proliferation while also contributing to resistance against chemotherapy.
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  • Circular RNAs, specifically circPCNXL2, were found to be significantly upregulated in intrahepatic cholangiocarcinoma (ICC), contributing to cancer cell growth and spread.
  • The study utilized various lab techniques to show that circPCNXL2 enhances ICC progression by binding to STRAP, which activates the ERK/MAPK signaling pathway, along with affecting the miR-766-3p/SRSF1 regulatory axis.
  • The findings indicate that circPCNXL2 could serve as a potential biomarker and therapeutic target for developing treatments against ICC.
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Objective: To screen the risk factors affecting the recurrence risk of patients with ampullary carcinoma (AC)after radical resection, and then to construct a model for risk prediction based on Lasso-Cox regression and visualize it.

Methods: Clinical data were collected from 162 patients that received pancreaticoduodenectomy treatment in Hebei Provincial Cancer Hospital from January 2011 to January 2022. Lasso regression was used in the training group to screen the risk factors for recurrence.

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Linearly polarized organic light-emitting diodes have become appealing functional expansions of polarization optics and optoelectronic applications. However, the current linearly polarized diodes exhibit low polarization performance, cost-prohibitive process, and monochromatic modulation limit. Herein, we develop a switchable dual-color orthogonal linear polarization mode in organic light-emitting diode, based on a dielectric/metal nanograting-waveguide hybrid-microcavity using cost-efficient laser interference lithography and vacuum thermal evaporation.

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  • SKA3 is a protein that helps with cell division and is linked to the growth of tumors, including cholangiocarcinoma (CCA), which is a type of cancer affecting the bile ducts.
  • Researchers used next-generation sequencing to identify SKA3's increased levels in CCA tissues compared to normal tissues and examined its effects on cancer cell growth under low oxygen conditions (hypoxia).
  • Findings revealed that SKA3 promotes CCA cell proliferation by enhancing fatty acid synthesis and interacting with other proteins to stabilize HIF-1a, a factor that helps cells adapt to hypoxia.
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Background: Caffeic acid tablets (CFA) are a proprietary Chinese medicine in treating thrombocytopenia. The efficacy and safety of CFA compared with other platelet-raising drugs for the treatment of thrombocytopenia have been widely reported in the literature, but there is no systematic evaluation. Therefore, we designed this meta-analysis to further establish the efficacy and safety of CFA in treating thrombocytopenia.

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  • The spindle assembly checkpoint (SAC) is crucial for normal cell division, and this study examines the role of MAD2, a key player in SAC, in cholangiocarcinoma (CCA), focusing on its impact on cancer progression.
  • Researchers discovered that elevated levels of MAD2 promote CCA progression and lymphatic spread by disrupting the USP44/LIMA1 complex, which leads to enhanced cancer cell survival and resistance to gemcitabine, a common chemotherapy drug.
  • The findings indicate that high MAD2 levels, along with low levels of USP44 or LIMA1, are linked to poorer survival outcomes for CCA patients, suggesting MAD2 could serve as a potential biomarker for prognosis and treatment planning.
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Background: Currently, the anticancer effects of metformin on different types of lung cancer have been frequently studied. However, the relationship between metformin and prognosis in nondiabetic patients with lung cancer remains controversial. To systematically evaluate the efficacy of metformin adjunctive therapy as the treatment for nondiabetic patients with advanced non-small cell lung cancer (NSCLC) to provide an evidence-based reference for clinical medication.

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  • * The study features advanced techniques like transgenic technology and gene silencing to analyze the structure, function, and evolutionary relationships of the BrSOC1b gene, revealing it encodes 213 amino acids and contains important conserved domains.
  • * Experimental results show that plants with increased expression of BrSOC1b, such as transgenic Arabidopsis thaliana, flower earlier, while silencing the gene in Chinese cabbage results in delayed flowering, establishing
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Quantum dots (QDs) laser has become an important way to solve micro-application problems in many fields. However, single wavelength distributed Bragg reflector (DBR) has many limitations in practical applications, such as signal transmission. How to realize multiwavelength DBR lasing output simply is a challenge.

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  • Cholangiocarcinoma (CHOL) is an aggressive liver cancer with a poor prognosis, and the study investigates the role of the gene ACSL4 in relation to CHOL.
  • The research shows that higher levels of ACSL4 in CHOL are linked to worse diagnosis and prognosis, and that it affects immune cell infiltration and metabolic pathways.
  • The results suggest that ACSL4 could serve as a new biomarker for CHOL and may influence the tumor environment, highlighting its potential impact on patient outcomes.
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  • Cholangiocarcinoma (CCA) is a type of liver cancer that has poor treatment options and outcomes, making it a significant medical challenge.
  • The study focused on the role of NUF2, a protein linked to cancer development, finding its levels were increased in CCA and associated with worse patient prognosis.
  • Results showed that NUF2 promotes the progression of CCA by affecting the degradation of another protein, TFR1, through specific cellular signaling pathways, suggesting that targeting the NUF2/TFR1/MAPK pathway could lead to new treatment strategies for CCA.
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Soil salinization, which is the accumulation of salt in soil, can have a negative impact on crop growth and development by creating an osmotic stress that can reduce water uptake and cause ion toxicity. The NHX gene family plays an important role in plant response to salt stress by encoding for Na/H antiporters that help regulate the transport of sodium ions across cellular membranes. In this study, we identified 26 genes in three cultivars of L.

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Multifunction-integrated semitransparent organic photovoltaic cells (STOPVs), with high power generation, colorful transmittance/reflectance, excellent ultraviolet (UV) protection, and thermal insulation, are fully in line with the concept of architectural aesthetics and photoprotection characteristics for building-integrated photovoltaic-window. For the indelible rainbow color photovoltaic window, one crucial issue is to realize the integration of these photons- and photoelectric-related multifunction. Herein, dynamic transmissive and reflective structural color controllable filters, with asymmetrical metal-insulator-metal (MIM) configurations (20 nm-Ag-HATCN-30 nm-Ag) through machine learning, are deliberately designed for colorful STOPV devices.

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Background And Aims: In recent years, more and more inflammatory indicators have been studied to predict the long-term survival of patients with ampullary carcinoma (AC) after radical resection, but these prognostic indicators are still controversial. Therefore, based on previous inflammation scores, this study established a novel, easily accessible, more feasible and more predictive prognostic marker [Carbohydrate antigen199 to gamma-glutamyltransferase ratio (CA19-9/GGT)] to better assess the prognostic significance in AC patients undergoing radical resection.

Methods: Overall survival (OS) and recurrence-free survival (RFS) were analyzed by Cox regression model.

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In this paper, we propose a novel (to our knowledge) vector beam by combining the radially polarized beams with the different polarization orders, which is called the grafted polarization vector beam (GPVB). Compared with the tight focusing of traditional cylindrical vector beams, GPVB can present more flexible focal field patterns by adjusting the polarization order of two (or more) grafted parts. Moreover, because the GPVB possesses the non-axisymmetrical polarization state distribution, which will lead to the spin-orbit coupling in its tight focusing, it can obtain the spatial separation of spin angular momentum (SAM) and orbital angular momentum (OAM) in the focal plane.

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Dihydromyricetin (DHY), the main flavonoid component in , has important benefits for health. The present study aimed to investigate the exact effects and possible mechanisms of DHY on diabetic cardiomyopathy (DCM). Male C57BL/6 mice and sirtuin 3 (SIRT3) knockout (SIRT3-KO) mice were injected with streptozotocin (STZ) to induce a diabetic model.

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  • ApoA-1, a key protein in high-density lipoprotein, plays a significant role in reducing liver damage and inflammation during hepatic ischemia-reperfusion injury, but its mechanisms were previously unclear.
  • In experiments on mice, lack of ApoA-1 led to worse liver damage and an increased inflammatory response, particularly noting a rise in a type of cell death called pyroptosis in macrophages.
  • The study concludes that ApoA-1 protects against liver injury by reducing pyroptosis through the TLR4-NF-κB signaling pathway, suggesting potential therapeutic options for managing hepatic ischemia-reperfusion injury.
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Optical modulation is the process of modifying the structure and elemental composition of materials so that the main optical parameters, including amplitude, frequency, and phase, are changed. Currently, much research attention has been directed toward ultrafast dynamics, but the process of modulation is often complex. To simplify the optical modulation process and improve the optical properties of perovskites for semiconductor quantum dot (QD) lasers, the process and physical mechanism underlying graphene QD ultrafast modulation of the optical properties of perovskite CsPbBr QDs were investigated.

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Complex regional pain syndrome type-I (CRPS-I) is a chronic neurological disorder that results in severe pain and affects patients' life quality. Conventional therapies usually lack effectiveness. Electroacupuncture (EA) is an effective physical therapy for relieving CRPS-I pain.

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  • Cholangiocarcinoma (CCA) is a highly lethal cancer with rising global cases, and new mutations were identified through whole-exome sequencing, notably ROBO1, which is linked to CCA progression.
  • The study utilized sequencing and experiments to reveal that downregulation of ROBO1 in CCA tissues correlates with poor prognosis and that it normally suppresses tumor growth and blood vessel formation.
  • Findings indicate ROBO1 acts as a tumor suppressor, suggesting it could be a prognostic marker and therapeutic target for improving CCA treatment outcomes.
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