Publications by authors named "RuiSarmento E Castro"
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Synopsis of recent research by authors named "RuiSarmento E Castro"
- RuiSarmento E Castro's research primarily focuses on the long-term safety and efficacy of antiviral regimens in the treatment of hepatitis C virus (HCV) genotype 1 infections, specifically evaluating the 3-DAA regimen combining ombitasvir, paritaprevir, and ritonavir with dasabuvir, along with ribavirin.
- His findings from the TOPAZ-I and TOPAZ-II clinical trials indicate that this treatment combination achieves sustained virologic response rates of approximately 95%, affirming its effectiveness in both clinical trial settings and real-world applications involving over 2300 patients.
- The ongoing phase 3b trials aim to assess the long-term clinical outcomes and liver disease progression in patients treated with the regimen for up to five years, highlighting the importance of prolonged safety monitoring and therapeutic effectiveness in chronic HCV management.
