Publications by authors named "Rui-xiang Chen"
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer and its prognosis remains poor. Although growing numbers of studies have verified the involvement of circular RNAs (circRNAs) in various cancer types, their specific functions in ICC remain elusive. Herein, a circRNA, circUGP2 is identified by circRNA sequencing, which is downregulated in ICC tissues and correlated with patients' prognosis.
View Article and Find Full Text PDFApolipoprotein A-1 Accelerated Liver Regeneration Through Regulating Autophagy Via AMPK-ULK1 Pathway.
Cell Mol Gastroenterol Hepatol
March 2024
Background & Aims: Apolipoprotein A-1 (ApoA-1), the main apolipoprotein of high-density lipoprotein, has been well studied in the area of lipid metabolism and cardiovascular diseases. In this project, we clarify the function and mechanism of ApoA-1 in liver regeneration.
Methods: Seventy percent of partial hepatectomy was applied in male ApoA-1 knockout mice and wild-type mice to investigate the effects of ApoA-1 on liver regeneration.
Background And Aims: In recent years, more and more inflammatory indicators have been studied to predict the long-term survival of patients with ampullary carcinoma (AC) after radical resection, but these prognostic indicators are still controversial. Therefore, based on previous inflammation scores, this study established a novel, easily accessible, more feasible and more predictive prognostic marker [Carbohydrate antigen199 to gamma-glutamyltransferase ratio (CA19-9/GGT)] to better assess the prognostic significance in AC patients undergoing radical resection.
Methods: Overall survival (OS) and recurrence-free survival (RFS) were analyzed by Cox regression model.
Article Synopsis
- ApoA-1, a key protein in high-density lipoprotein, plays a significant role in reducing liver damage and inflammation during hepatic ischemia-reperfusion injury, but its mechanisms were previously unclear.
- In experiments on mice, lack of ApoA-1 led to worse liver damage and an increased inflammatory response, particularly noting a rise in a type of cell death called pyroptosis in macrophages.
- The study concludes that ApoA-1 protects against liver injury by reducing pyroptosis through the TLR4-NF-κB signaling pathway, suggesting potential therapeutic options for managing hepatic ischemia-reperfusion injury.
Article Synopsis
- * CdTeSe/ZnS core-shell quantum dots (QDs) are being explored for their potential in biomedical imaging and therapy, thanks to their near-infrared capabilities and environmentally friendly production.
- * The study demonstrates that these QDs, when activated by a blue laser, can accurately target and induce cell death in liver cancer cells, offering a promising new approach to cancer treatment using micro-nano technology.
Background: The role of hepatic resection in the treatment of type I and II hilar cholangiocarcinoma (HCCA) remains controversial. In the present study, we aimed to identify whether hepatic resection was necessary for type I and II HCCA.
Methods: A total of 23 patients classified as type I and II HCCA undergoing surgical resection were included in this study.
This study significantly aims to analyze the effect of CFX coated gold nanoparticles on the allergic rhinitis in mouse model. Female BALB/C mice were intraperitoneally injected with ovalbumin and aluminum hydroxide in order to sensitize on 0th, 7th, 14th, and 21st day. Nano‑gold was also nasally inoculated earlier to the intranasal administration of OVA.
View Article and Find Full Text PDFObjective: To study the effect of down-regulation of histone deacetylase 2 (HDAC2) expression on cell proliferation and cell cycle in cervical carcinoma cell lines HeLa.
Methods: HDAC2 siRNA and control siRNA were transfected to HeLa cells. CCK-8 and flow cytometry were used to analyze the changes of cell proliferation and cell cycle, respectively.
Objective: To observe the therapeutic effect of moxibustion in re-treatments patients of tuberculosis.
Methods: Fifty-three cases were randomly divided into an observation group (n = 31) and a control group (n = 22). They were treated with routine chemotherapeutic program of western medicine with garlic moxibustion on main points Feishu (BL 13), Gaohuang (BL 43), Shenzhu (GV 12), etc.