Publications by authors named "Rui-ping Xu"
[Metabolomics study on anti-radiation effect of Yiguan Decoction].
Zhongguo Zhong Yao Za Zhi
October 2024
The gas chromatography-mass spectrometer(GC-MS) metabolomics method was used to investigate the anti-radiation effect of Yiguan Decoction water extract on mice and explore its related pathways and mechanisms of action. Healthy SPF male mice from Kunming were randomly assigned to six groups: blank group, model group, positive drug group, and high-dose, medium-dose, and low-dose groups of Yiguan Decoction, with ten mice in each group. Mice were prophylactically dosed for six days, and ~(60)Co γ ray with 5 Gy was used to establish a radiation mouse model.
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- Sleep deprivation (SD) reduces body weight and increases resting metabolic rate (RMR) in C57BL/6J mice, indicating enhanced energy metabolism.
- The study observed significant increases in thermogenic gene expression in both brown adipose tissue (BAT) and skeletal muscle during a 7-day SD period, particularly for genes related to AMPK activation.
- Findings suggest that SD triggers adaptive thermogenesis through specific molecular pathways (AMPK - PGC1α - UCP1 in BAT, and AMPK - UCP3 in skeletal muscle), highlighting a potential physiological response to lack of sleep.
Article Synopsis
- The study highlights the importance of spatially separating dopants to improve the lifespan of nanoribbon p-n junctions, which are typically costly to create using van der Waals heterostructures.
- Using atomistic quantum mechanical simulations, researchers found that bending nanoribbons alters where dopants preferentially locate, depending on their atomic sizes.
- Larger dopants tend to cluster at the outer edges on the tensile side, while smaller ones prefer the inner edges on the compressive side, allowing for better spatial separation of n-type and p-type dopants in a more cost-effective way.
Background: The association of lipids and cancer has varied greatly among different cancer types, lipid components and study populations. This study is aimed to investigate the association of serum lipids and the risk of malignant lesions in esophageal squamous epithelium.
Methods: In the "Endoscopic Screening for Esophageal Cancer in China" (ESECC) trial, serum samples were collected and tested for total cholesterol (TC), triglycerides, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol at the time of subject enrollment.
The aqueous biphasic system (ABS) plays a key role in the separation of bioactive substances, and the establishment and application of a low-molecular-weight polyethylene glycol (PEG) ABS remains a challenge in high-speed countercurrent chromatography (HSCCC). In this work, an ABS of low-molecular-weight PEG, namely PEG400-Na2SO4-H2O (20%-16%-64%, w/w/w), was developed on the basis of the phase diagram, and the phase forming time and ratio, and applied to HSCCC for the separation of polysaccharides. The crude polysaccharide extracted from Pericarpium granati (PGP) was successfully separated and three purified polysaccharides were obtained: PGP-1, with an average molecular weight of 13,210Da and composed of xylose (12.
View Article and Find Full Text PDF[Model for predicting survival of patients with severe virus hepatitis and its clinical application].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
October 2005
Objective: To study prospectively the short-time survival of patients with severe virus hepatitis using model of severe liver diseases (MSLD) established by our previous study.
Methods: One hundred and three patients with severe hepatitis were included by cohort study. Of them, there were 85 patients with severe chronic hepatitis patients, 10 acute and 8 subacute severe hepatitis patients, respectively.