A population-based characterization study of anti-mitochondrial M2 antibodies and its consistency with anti-mitochondrial antibodies.

Objective: This study aims to estimate the prevalence of anti-mitochondrial antibody subtype M2 (AMA-M2) and assess its consistency with AMA in a general population.

Methods: A total of 8954 volunteers were included to screen AMA-M2 using enzyme-linked immunosorbent assay. Sera with AMA-M2 >50 RU/mL were further tested for AMA using an indirect immunofluorescence assay.

[Levels of fat-soluble vitamins A, D, and E and their influencing factors in children with obesity].

Objectives: To investigate the levels of fat-soluble vitamins A, D, and E in children with obesity and their influencing factors.

Methods: A total of 273 children with obesity who attended the Department of Clinical Nutrition, Xi'an Children's Hospital, from January 2019 to April 2021 were enrolled as the obesity group. A total of 226 children with normal body weight who underwent physical examination during the same period were enrolled as the control group.

Thalidomide-based Pt(IV) prodrugs designed to exert synergistic effect of immunomodulation and chemotherapy.

Combination of immune- and chemo-therapy has become a new trend in cancer treatment. Food and Drug Administration (FDA)-approved immune-modulatory agent, thalidomide, can modulate the related proteins of upstream signaling pathway of programmed cell death-ligand 1 (PD-L1), including nuclear transcription factor κB (NF-κB), hypoxia inducible factor-1α (HIF-1α), epidermal growth factor receptor (EGFR), and signal transducer and activator of transcription 3 (STAT3), all acting as key antitumor target proteins. In this work, we conjugated thalidomide with oxidized cisplatin to construct multi-functional Pt(IV) prodrugs, named thaliplatins 4-6, to investigate the anti-tumor effect of immuno- and chemo-therapy.

Treatment of lower part of glenoid fractures through a novel axillary approach: A case report.

Background: Based on the location and size of the fracture block, open reduction and internal fixation can be employed or assisted for shoulder arthroscopy in the treatment of glenoid fractures. However, the treatment of lower part of glenoid fractures through a novel axillary approach has not been reported so far.

Case Summary: A 22-year-old right-handed man was transferred to our outpatient clinic because of right shoulder injury during a traffic accident.

Performance Evaluation of Antiphospholipid Antibodies on INOVA Quanta Flash System.

Background: The diagnosis of antiphospholipid syndrome (APS) relies predominantly on the laboratory measurement of antiphospholipid antibodies (aPLs). We attempt to verify the analytical performance of anticardiolipin antibodies (aCL) IgA/IgG/IgM and anti-β2-glycoprotein I antibodies (aβ2GPI) IgA/IgG/IgM on a high-throughput automated immunoassay platform.

Methods: Limit of blank (LOB), limit of detection (LOD), imprecision, and linearity were calculated according to the corresponding Clinical and Laboratory Standards Institute (CLSI) guidelines protocols.

Ketoplatin in triple-negative breast cancer cells MDA-MB-231: High efficacy and low toxicity, and positive impact on inflammatory microenvironment.

Triple-negative breast cancer (TNBC) shares the molecular features facilitating epithelial-to-mesenchymal transition (EMT), which contributed to tumor invasion and metastasis. A platinum(IV) conjugate ketoplatin deriving from FDA-approved drugs cisplatin and ketoprofen was designed and prepared to enhance antitumor activity and suppress EMT in TNBC via positive impact on inflammatory microenvironment by modulating COX-2 signal. As a prodrug, ketoplatin afforded 50.

Oxidative Stress Induces Chondrocyte Apoptosis through Caspase-Dependent and Caspase-Independent Mitochondrial Pathways and the Antioxidant Mechanism of Angelica Sinensis Polysaccharide.

Introduction: Chondrocyte apoptosis is considered one of the pathogenic factors of osteoarthritis (OA), but its importance in the pathogenesis of OA remains unclear. Recent research adds progress to the knowledge that the mitochondrial signaling pathway mediates chondrocyte apoptosis in OA.

Method: Rat chondrocyte exposed to HO was used as the experimental oxidative stress model.

[Activating Efficiency of Iron-copper Bimetallic Organic Framework MIL-101(Fe,Cu) Toward H O for Degradation of Dyes].

Practical use of heterogeneous Fenton-like catalysis is inhibited by poor mass transfer and slow conversion of Fe(Ⅲ) to Fe(Ⅱ). In this study, we prepared a novel iron-copper bimetallic organic framework (MIL-101 (Fe,Cu)) using the solvothermal method, and carefully investigated its interfacial characters, catalytic efficacy toward dyes with methylene blue as a model pollutant, and the catalytic activating mechanisms involved in it. The MIL-101(Fe,Cu) exhibited a three-dimensional octahedral shape with a complete crystal structure.

Anticancer Melatplatin Prodrugs: High Effect and Low Toxicity, MT1-ER-Target and Immune Response .

Multitargeted therapy could rectify various oncogenic pathways to block tumorigenesis and progression. The combination of endocrine-, immune-, and chemotherapy might exert a highly synergistic effect against certain tumors. Herein, a series of smart Pt(IV) prodrugs -, named Melatplatin, were rationally designed not only to multitarget DNA, MT1, and estrogen receptor (ER) but also to activate immune response.

[Metabolic Functional Analysis of Dominant Microbial Communities in the Rapid Sand Filters for Drinking Water].

Rapid sand filter (RSF) is widely used in drinking water treatment plants. Rapid filtration is always considered a physicochemical process, but the effect of the microorganisms that attach to the filter media remain inadequately investigated. In order to understand the composition and functional characteristics of microbial communities in RSFs, influent water, effluent water, and filter materials from eleven RSFs in eight Chinese cities were sampled and analyzed.

[Catalytic Degradation of Rhodamine B by FeOCl Activated Hydrogen Peroxide].

The wide application of traditional Fenton reactions was firmly restricted by the requirement for harsh acid conditions, as well as the inevitable generation of iron slurry. The FeOCl nanosheets, prepared by the chemical vapor transformation method, were used to degrade RhB via activation of HO. The FeOCl was characterized by a field emission scanning electron microscope (FE-SEM) and X-Ray Diffractometer (XRD), the results showed that FeOCl exhibited a fine crystal structure and nanosheet-like morphology, which was favorable for exposure of active sites.

Fuplatin: An Efficient and Low-Toxic Dual-Prodrug.

As FDA-approved chemotherapeutic agents, cisplatin, oxaliplatin, and 5-fluorouracil are widely used in clinic but limited by severe side-effects. To ameliorate their respective defects, a series of "dual-prodrug" by linking oxoplatin and 5-FU were designed and synthesized. The assembled compounds 10-17, named Fuplatin, exhibited much higher cytotoxicity against the tested cancer cells while lower cytotoxicity toward the human normal lung cells than free drugs or their combinations.

[Principle and techniques for fluoride pollution control in drinking water].

Long-term natural geochemical processes result in wide occurrence of fluoride contamination in underground water and fluoride exposure via drinking water for over 500 million people glo-bally. The control of fluoride pollution and fluorosis is one of the most important issues for drinking water safety. In the past several decades, many initiatives failed in defluoridation of water.

TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis.

Accumulating evidences suggested that tumor necrosis factor alpha inducible protein 3 (TNFAIP3) gene rs10499194, rs13207033 polymorphisms may be associated with the risk of rheumatoid arthritis (RA). However, these studies yielded contradictory findings. To clarify convincing associations, we conducted a comprehensive meta-analysis by searching in PubMed, Embase, and the China Knowledge Resource Integrated Database.

Association of IL12B Gene Polymorphisms with Rheumatoid Arthritis: A Meta-analysis.

Background And Aims: Currently published papers regarding the relationship between interleukin (IL)-12B gene polymorphisms and rheumatoid arthritis (RA) are contradictory. The aim of this meta-analysis was to evaluate the associations between the IL-12B gene polymorphisms (rs3122227 and rs6887695) and RA risk.

Methods: We searched PubMed, Embase, the Cochrane Library and the China Knowledge Resource Integrated Database.

Is It Time to Phase Out the Austin Moore Hemiarthroplasty? A Propensity Score Matched Case Control Comparison versus Cemented Hemiarthroplasty.

We compared the Austin Moore hemiarthroplasty versus cemented hemiarthroplasties using a propensity score matched cased control study. For a consecutive cohort of 450 patients with displaced intracapsular neck of femur fractures, 128 matched cases in each group were selected based on age, gender, walking status, nursing home residency, delays in surgery, ASA score, and the Charlson comorbidity score. At a mean follow-up of 16.

Re: "PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer's Disease in an Asian Population".

Liu et al. have carried out a meta-analysis of case-control studies to investigate the association between PICALM gene rs3851179 polymorphism and Alzheimer's disease in an Asian population. However, several important issues should be noted.

[Characterization of manganese oxidation by Pseudomonas sp. QJX-1].

A manganese-oxidizing bacteria (QJX-1) was isolated from the soil of a manganese mine. It was identified as Pseudomonas sp. QJX-1 by 16S rDNA sequencing.

[Formation of disinfection by-products by Microcystis aeruginosa intracellular organic matter: comparison between chlorination and bromination].

In order to illustrate the effects of released algal organic matter in cyanobacteria blooms on raw water quality and water treatment process, intracellular organic matter (IOM) of Microcystis aeruginosa, which is the dominant species in cyanobacteria blooms, was chosen as a precursor and characterized. In addition, the transformation of IOM and the formation of disinfection byproducts were evaluated at different pH of 6.5, 7.

B-cell Lymphoma 2 rs17757541 C>G polymorphism was associated with an increased risk of gastric cardiac adenocarcinoma in a Chinese population.

Aim: Apoptosis has been considered as a fundamental component in cancer pathogenesis, and related genetic factors might play an important role in gastric cardiac adenocarcinoma (GCA) genesis.

Methods: We conducted a hospital based case-control study to evaluate the genetic effects of functional single nucleotide polymorphisms (SNPs): BCL2 rs17757541 C>G, BCL2 rs12454712 T>C, FAS rs2234767 G>A, FASL/FASLG rs763110 C>T, ERBB2 rs1136201 A>G and VEGFR2/KDR rs11941492 C>T on the development of GCA. A total of 243 GCA cases and 476 controls were recruited for the study and genotypes were determined using a custom-by-design 48-Plex SNPscanTM Kit.

Enhanced arsenic removal by in situ formed Fe-Mn binary oxide in the aeration-direct filtration process.

Field studies were conducted to evaluate the feasibility of an in situ formed Fe-Mn binary oxide (in situ FMBO) for improving arsenic (As) removal in the aeration-direct filtration process. The transformation and transportation of As, Fe, and Mn in the filter bed were also investigated. The in situ FMBO increased the As removal efficiency by 20-50% to keep the residual As below 10 μg/L.

Plasmonic-induced optical transparency in the near-infrared and visible range with double split nanoring cavity.

Plasmonic-induced optical transparency with double split nanoring cavity is investigated with finite difference time domain method. The coupling between the bright third-order mode of split nanoring with one gap and the dark quadrupole mode of split nanoring with two gaps leads to plasmonic analogue of electromagnetically induced transparency. The transparence window is easily modified to the near-infrared and visible range.