Temporal retinal thinning might be an early diagnostic indicator in male pediatric X-linked Alport syndrome.

Aim: To evaluate temporal retinal thinning changes in retinal layers using spectral-domain optical coherence tomography (SD-OCT) in pediatric X-linked Alport syndrome (XLAS) patients.

Methods: A retrospective case-control study. SD-OCT scans of pediatric patients diagnosed with XLAS and age- and sex-matched healthy control participants were reviewed.

Absence of ephrin-A2/A3 increases retinal regenerative potential for Müller cells in knockout mice.

Müller cells (MC) are considered dormant retinal progenitor cells in mammals. Previous studies demonstrated ephrin-As act as negative regulators of neural progenitor cells in the retina and brain. It remains unclear whether the lack of ephrin-A2/A3 is sufficient to promote the neurogenic potential of MC.

Intrinsic determinants of optic nerve regeneration.

Objective: To review the functions of these intracellular signals in their regulation of retinal ganglion cell (RGC) axon regeneration.

Data Sources: Relevant articles published in English or Chinese from 1970 to present were selected from PubMed. Searches were made using the terms "intrinsic determinants, axon regeneration, RGC, optic nerve regeneration, and central nervous system axon regeneration.

[The research advances of intrinsically photosensitive retinal ganglion cells].

Intrinsically photosensitive retinal ganglion cells (ipRGC) are photosensitive cell besides rods and cones. These cells are crucial for circadian photoentrainment and pupillary light reflex. Some chronobiologists and ophthalmologists have focused on these ipRGC in recent years.