Publications by authors named "Rui-Xia Xu"
Article Synopsis
- Lipoprotein(a) [Lp(a)] is recognized as a potential predictor for atherosclerotic cardiovascular disease (ASCVD), with a study involving 9944 Chinese patients revealing its association with increased cardiovascular event risk based on current risk stratification guidelines.
- Patients were categorized into very-high-risk (VHR) and non-VHR subgroups, with Lp(a) plasma levels influencing the prevalence of cardiovascular events (CVEs) observed over an average follow-up of 38.5 months.
- The results indicated that higher Lp(a) levels correlate with a significant increase in CVE risk, especially in the VHR subgroup, with adjusted hazard ratios showing a 2.18 times higher risk in the highest Lp
Article Synopsis
- This study looked at a substance called Endothelin-1 (ET-1) and how it might be linked to heart problems in people with diabetes and other blood sugar issues.
- Researchers followed nearly 8,000 patients with heart disease over a few years to see if higher levels of ET-1 could predict serious heart events, like heart attacks.
- They found that patients with diabetes or prediabetes and higher ET-1 levels were more likely to have these heart problems, suggesting ET-1 could help doctors predict risks in these patients.
Article Synopsis
- - The study investigates the clinical significance of new indices, TyAG and TyAG-BMI, which incorporate estimated average glucose into existing measures of insulin resistance (TyG and TyG-BMI) in patients with atherosclerotic cardiovascular disease (ASCVD).
- - Conducted on nearly 10,000 Chinese patients, the study analyzed cardiovascular events over 38.5 months and found that higher values of TyAG and TyAG-BMI correlated with increased cardiovascular risk factors and event rates.
- - Results indicated that TyAG and TyAG-BMI might provide improved risk prediction for cardiovascular events compared to the traditional indices, with TyAG-BMI showing the strongest predictive capability.
Article Synopsis
- - The study investigates how stress-related glycemic indicators (like admission blood glucose, stress-hyperglycemia ratio, and glycemic gap) affect cardiovascular mortality outcomes in patients over 80 years old who experienced acute myocardial infarction (AMI).
- - Researchers analyzed data from 933 elderly patients and found that higher levels of these glycemic indicators were associated with significantly increased risks of both short-term (30 days) and long-term cardiovascular mortality.
- - The results reveal a J-shaped effect for admission blood glucose and a U-shaped effect for the other two indicators, highlighting their importance in assessing the health of older adults following AMI.
Aim: No data are currently available regarding the association between Lp(a) and the cardiovascular outcomes in patients with coronary artery disease (CAD) according to their family history (FHx) of CAD. This study aimed to evaluate the significance of Lp(a) in predicting major adverse cardiovascular events (MACEs) in patients with chronic coronary syndrome (CCS) with or without FHx.
Methods: A total of 6056 patients with CCS were enrolled.
Article Synopsis
- * A study involved 8,263 patients with stable coronary artery disease, categorizing them by Lp(a) and Fib levels to monitor ischemic stroke occurrences over a median follow-up of 37.7 months.
- * Results showed that patients with high levels of both Lp(a) and Fib had the highest incidence of ischemic stroke, suggesting that assessing both factors together could better predict stroke risk compared to evaluating them separately.
[This corrects the article DOI: 10.3389/fendo.2022.
View Article and Find Full Text PDFArticle Synopsis
- Karenia mikimotoi and Prorocentrum shikokuense are harmful algal species that often bloom along China's coasts, impacting the ecosystem.
- The study investigates their competitive interactions, revealing that K. mikimotoi's metabolism is enhanced while its cell cycle is hindered when co-cultured with P. shikokuense, which conversely has its energy and nutrient uptake diminished.
- Key genes, including those for phospholipase A2 and nitrate reductase, were found to be up-regulated in K. mikimotoi, suggesting these may influence its competitive advantage and allelopathic effects in their interactions.
Research Question: Non-invasive preimplantation genetic testing for aneuploidies (niPGT-A) avoids the possible detrimental impact of invasive PGT-A on embryo development and clinical outcomes. Does cell-free DNA (cfDNA) from spent blastocyst culture medium (BCM) reflect embryonic chromosome status better than trophectoderm (TE) biopsy?
Design: In this study, 35 donated embryos were used for research and the BCM, TE biopsy, inner cell mass (ICM) and residual blastocyst (RB) were individually picked up from these embryos. Whole genome amplification (WGA) was performed and amplified DNA was subject to next-generation sequencing.
Background: The relationship between remnant cholesterol (RC) and atherosclerotic cardiovascular risk has been given increasing attention in recent years. However, its association with verbal learning and memory performance has not been reported.
Methods: Data were extracted from the National Health and Nutrition Examination Survey (NHANES) 2011-2014 database.
Background: Hypertension is a known risk factor for cardiovascular disease; however, its impact on clinical outcomes in patients with heterozygous familial hypercholesterolemia (HeFH) is unclear. Hence, we aimed to investigate the effects of hypertension on severity of coronary artery atherosclerosis and cardiovascular outcomes in patients with HeFH.
Methods: A total of 480 patients with clinical or molecular diagnosis of definite or probable familial hypercholesterolemia according to Dutch Lipid Clinic Network criteria (DLCN score ≥6) were included in the study.
Background: The positive relationship between metabolic healthy obesity (MHO) and cardiovascular risk has been under debate in recent years. Previously, strong evidence supported the causal role of increased plasma lipoprotein(a) [Lp(a)] levels in cardiovascular disease (CVD). The current study aimed to investigate the different associations of Lp(a) and cardiovascular events (CVEs) in patients with coronary artery disease (CAD) and different metabolic phenotypes.
View Article and Find Full Text PDFBackground: Currently, remnant cholesterol (RC), lipoprotein(a) [Lp(a)], and inflammation are considered the principal residual cardiovascular risk (RCVR) factors. This study sought to evaluate the combined impact of RC, Lp(a), and inflammation on prognosis of statin-treated patients with chronic coronary syndrome (CCS), which has not been investigated.
Methods: A total of 6839 patients with CCS were consecutively enrolled.
Background: Familial hypercholesterolemia (FH) is a metabolic disease in which patients are prone to develop premature atherosclerosis (AS). Sorbin and SH3 Domain Containing 2 (SORBS2) is known to play a role in coronary heart disease (CHD). However, the mechanism underlying SORBS2 involvement in the development of hypercholesterolemia remains unknown.
View Article and Find Full Text PDFArticle Synopsis
- A study involving 9,944 patients with atherosclerotic cardiovascular disease (ASCVD) aimed to understand the variability in recurrent events among them, particularly in a Chinese population.
- Researchers found that as the number of major ASCVD events increased, patients exhibited more high-risk conditions and a higher prevalence of severe coronary lesions.
- The presence of diabetes was linked to worse outcomes in patients with multiple events, highlighting the importance of tailored risk assessments rather than a one-size-fits-all approach.
Sodium ferulate (SF) is the sodium salt of ferulic acid, which is one of the effective components of Angelica sinensis and Lignsticum chuanxiong , and plays an important role in protecting the cardiovascular system. In this study, myocardial hypertrophy was induced by angiotensin II 0.1 μmol/L in neonatal Sprague-Dawley rat ventricular myocytes.
View Article and Find Full Text PDFBackground: The risk of liver fibrosis in non-alcoholic fatty liver disease (NAFLD) can be easily evaluated by noninvasive scoring systems, of which the NAFLD fibrosis score (NFS) is the most commonly used. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a new predictor of cardiovascular events, has been reported to be associated with cardiovascular outcomes and NAFLD. However, the relationship of NFS with PCSK9 and their prognostic abilities in cardiovascular risks are unknown.
View Article and Find Full Text PDFBackground: Lipoprotein (a) [Lp(a)] is a causal risk factor for cardiovascular diseases, while its role in vascular calcification has not been well-established. Here, we investigated an association of Lp(a) with vascular calcification using population-based and in vitro study designs.
Methods: A total of 2806 patients who received coronary computed tomography were enrolled to assess the correlation of Lp(a) with the severity of coronary artery calcification (CAC).
Background: Although the presence of physical signs [tendon xanthomas and/or corneal arcus (TX/CA)], are associated with the risk of coronary artery disease in patients with heterozygous familial hypercholesterolemia (HeFH), their relationship with genotypes and clinical characteristics has not been fully determined. This study aimed to examine the association of TX/CA with genetic mutation, lipid- and inflammation-related markers, the severity of coronary stenosis or calcification, and cardiovascular events (CVEs) in patients with HeFH.
Methods: LDLR, APOB, and PCSK9 genes were screened in 523 HeFH patients, and patients with TX/CA (n = 50) were 1:4 propensity score-matched to patients without TX/CA (n = 200) to adjust for age and sex.
Background: It has been demonstrated that berberine (BBR), a kind of alkaloid derived from Chinese herbal medicine, has multiple pharmacological effects on human's diseases including anti-atherosclerosis action. However, although the previous studies showed that the beneficial impact of BBR on atherosclerosis might be associated with proprotein convertase subtilisin/kexin type 9 (PCSK9), the exact underlying mechanism are not fully determined. The present study aimed to investigate potential mechanisms of anti-atherosclerosis by BBR using ApoE mice.
View Article and Find Full Text PDFBackground: Continuous refinement of atherosclerotic cardiovascular disease (ASCVD) stratification has raised the definition of very-high-risk (VHR) recently, which has been underutilized in China. We aimed to identify patients at VHR and evaluate their performances in a Chinese population.
Methods: A total of 9944 patients with ASCVD was continuously enrolled.
Background: It has been demonstrated that patients with type 2 diabetes mellitus (DM) is associated with increased cardiovascular risk. However, little is known regarding the long-term prognosis in diabetic patients who experience mild-to-intermediate coronary artery stenosis (CAS). This study was to assess the clinical outcomes of diabetic patients with different severity of CAS.
View Article and Find Full Text PDFArticle Synopsis
- A recent study suggests that metabolic-associated fatty liver disease (MAFLD) may be a more appropriate term than nonalcoholic fatty liver disease (NAFLD) and examines its effects on major cardiovascular events in chronic coronary syndrome patients.
- The study followed 3,306 patients with MAFLD and found a higher occurrence of major adverse cardiac events (MACEs) in this group compared to matched controls without MAFLD over an average period of about 55 months.
- The results indicate that MAFLD significantly increases the risk of MACEs, even when considering NAFLD criteria, highlighting the clinical importance of using MAFLD for better patient assessment.
Background: Visit-to-visit variability in lipid has been suggested as a predictor of major adverse cardiovascular events (MACEs). However, no evidence exists on the prognostic value of lipid variability in patients with familial hypercholesterolemia (FH). This prospective cohort study aimed to investigate whether lipid variability affects future MACEs in patients with FH receiving standard lipid-lowering therapy.
View Article and Find Full Text PDFAims: Familial hypercholesterolemia patients are characterized by early onset of coronary artery calcification and atherosclerosis, and high incidence of cardiovascular events. Plasma proprotein convertase subtilisin/kexin type 9 was reported to be a predictor for cardiovascular risk in the general population. However, its prognostic value for predicting recurrent cardiovascular events in familial hypercholesterolemia patients remains undetermined.
View Article and Find Full Text PDF