[Effects of seed grading on population regularity degree and yield of summer maize].

Grading seeds based on grain size is an effective measure to improve population regularity degree and increase the yield of summer maize. Taking Denghai 605 as the experimental material, we set up a field experiment with treatments based on grain size: large seeds (L), medium-round seeds (MR), medium-flat seeds (MF), medium-round and medium-flat mixed seeds (MRF), and small seeds (S), with no-grading seeds as control (CK). We investigated seedling emergence rate, population regularity degree (including height, ear height and stem diameter), seedling sturdiness index, photosynthetic characteristics, dry matter accumulation and distribution characteristics, and yield.

Structural identification of 4-benzyl-voglibose hydrochloride monohydrate using NMR and single-crystal X-ray diffraction methods.

The chemical structure studies on an important related substance of voglibose have been carried out using NMR spectroscopy and single crystal X-ray crystallography. For the structure identification study, hydrochloride monohydrate of this compound was isolated and purified. Its molecular structure was characterized and analyzed using 1D (1H NMR, 13C NMR, and DEPT) and 2D (1H,1H-COSY, HSQC, HMBC, TOCSY, and ROESY) NMR spectra.

Effects of calcium and magnesium on acute and chronic neurotoxicity caused by oxaliplatin: A meta-analysis.

The primary toxicity of oxaliplatin is neurotoxicity. Calcium and magnesium (Ca/Mg) are reported to be beneficial in protecting against this adverse effect. However, the results obtained from clinical trials are not definitive.

[Therapeutic effect of indole-3-carbinol on pig serum-induced hepatic fibrosis in rats].

This study is to investigate the therapeutic effect and mechanism of indole-3-carbinol (I3C) on pig serum-induced liver fibrosis of rats. The liver fibrotic model of rats was induced by pig serum. After models were successfully established, rats in the treatment groups were administered with I3C through intraperitoneal injection or curcumin by intragastric administration, daily for 17 days.

Indole-3-carbinol enhances the resolution of rat liver fibrosis and stimulates hepatic stellate cell apoptosis by blocking the inhibitor of κB kinase α/inhibitor of κB-α/nuclear factor-κB pathway.

Hepatic stellate cells (HSC) play a pivotal role in liver fibrosis, and the clearance of activated HSC by apoptosis is associated with the resolution of liver fibrosis. The development of strategies that promote this process in a selective way is therefore important. We evaluated the effects of indole-3-carbinol (I3C), a nutritional component derived from vegetables from the Brassica family, on liver fibrosis and HSC apoptosis.

[Synthesis and anti-inflammatory analgesic activities of phenylfuroxan-coupled diclofenac].

Aim: To search for new derivatives of diclofenac (DC) having higher potency than the parent drug and lacking its undesirable effects.

Methods: Coupling DC with NO donor 3-hydroxymethyl-4-phenylfuroxan and its isomer through esterification, evaluating anti-inflammatory and analgesic activities, observing side effects in the rat gastrointestinal (GI) tract and assessing NO releasing ability both in vitro and in vivo.

Results: Fifteen new compounds including nine target ones (II1-9) were synthesized, and their structures were determined by IR, 1HNMR, MS and elemental analysis.