Neuroprotective lindenane sesquiterpenoids from the roots of Lindera aggregata (Sims) Kosterm.

Eleven previously undescribed lindenane sesquiterpenoids, lindaggrols A-K (1-11), were isolated from the roots of Lindera aggregata (Sims) Kosterm, together with five known ones. Their structures were elucidated by HR-ESI-MS, NMR, and single-crystal X-ray diffraction analyses. Lindaggrol A (1) is an undescribed rearranged dinor-lindenane with an unprecedented 3/5/5 tricyclic scaffold.