Publications by authors named "Rui-Shan He"
Dysbiosis promotes recurrence of adenomatous polyps in the distal colorectum.
World J Gastrointest Oncol
August 2024
Article Synopsis
- - The study investigates the bacteria in the mucosal tissue surrounding recurrent colorectal polyps, which are pre-cancerous growths, as current treatments mainly involve removal without understanding the underlying biology.
- - It involved collecting mucosal samples from patients with different types of polyps and healthy individuals, using advanced sequencing techniques to analyze bacterial diversity and patterns.
- - Results showed that patients with polyps had lower levels of beneficial probiotics and higher levels of harmful bacteria, indicating a potential link between bacterial composition and colorectal polyp development, with age and gender also influencing these bacterial profiles.
Article Synopsis
- * The autonomic nervous system (ANS) influences the tumor environment and can affect the behavior of MDSCs via its sympathetic and parasympathetic components.
- * Understanding how ANS signaling impacts MDSC activity could lead to innovative cancer treatment strategies targeting these cells.
Cancer receives enduring international attention due to its extremely high morbidity and mortality. Immunotherapy, which is generally expected to overcome the limits of traditional treatments, serves as a promising direction for patients with recurrent or metastatic malignancies. Bacteria-based vectors such as take advantage of their unique characteristics, including preferential infection of host antigen presenting cells, intracellular growth within immune cells, and intercellular dissemination, to further improve the efficacy and minimize off-target effects of tailed immune treatments.
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