Genipin inhibits the scleral expression of miR-29 and MMP2 and promotes COL1A1 expression in myopic eyes of guinea pigs.

Purpose: High myopia can lead to blindness. Genipin is a collagen cross-linking agent that may be used to treat myopia. However, the mechanism of action of genipin for the treatment of myopia is unclear.

Effects of the long wavelength-filtered continuous spectrum on natural refractive development in juvenile guinea pigs.

Aim: To investigate the effects of spectral composition and light intensity on natural refractive development in guinea pigs.

Methods: A total of 124 pigmented guinea pigs (2-week-old) were randomly assigned to three groups at high (Hi; 4000 lx), medium (Me; 400 lx) and low (Lo; 50 lx) light intensities under a 12:12 light/dark cycle for 6wk. Each group was subdivided into subgroups with the following spectra: broad spectrum Solux halogen light (BS), 600 nm above-filtered continuous spectrum (600F), 530 nm above-filtered continuous spectrum (530F), and 480 nm above-filtered continuous spectrum (480F; HiBS: =10, Hi600F: =10, Hi530F: =10, Hi480F: =10, MeBS: =10, Me600F: =10, Me530F: =10, Me480F: =10, LoBS: =11, Lo600F: =12, Lo530F: =10, Lo480F: =11).

Theoretical studies on the electronic structures and optical properties of (Cu, C)-codoped rutile TiO from GGA+U calculations.

The electronic structures, formation energy and optical properties of Cu-doped, C-doped, and (Cu, C)-codoped TiO were investigated by the projector augmented wave (PAW) method within GGA + U approximation. The results show that the lattice distortion of the Cu@i1&C@i2 system is the largest in all doping systems. The optical absorption edges of the C@i system and the Cu@i1&C@i2 system appear a blue-shift, which is attributed to the band gap expansion and some deep states generation.

[Preparation and up-conversion luminescence properties of Yb3+/Tm3+ co-doped Sb2O4 powder].

The Sb2O4:Yb3+, Tm3+ up-conversion luminescence powder with excellent physical, chemical stability and relative low phonon energy was synthesized by the high temperature solid-state reaction and its up-conversion luminescence property was investigated. Under the 980 nm excitation, infrared and blue up-conversion emissions centered at 800 and 480 nm were observed, which were assigned to the 1G4-->3H6 and 3H4-->3 He transitions of Tm2+, respectively. The influence of Yb3+ and Tm3+ concentration on the up-conversion emission property was also obtained.

Poly[[diaqua-tris(μ2-4,4'-bi-pyridine)-bis[μ2-2-(carb-oxylato-methyl-sulfan-yl)nicotinato]dicobalt(II)] 1.3-hydrate].

The title complex, [Co2(C8H5NO4S)2(C10H8N2)3(H2O)2]·1.3H2O, was synthesized under hydro-thermal conditions. The Co(II) ion is six-coordinated in a slightly distorted octa-hedral environment resulting from two carboxyl-ate O atoms of two 2-carb-oxy-methyl-sulfanyl nicotinate (2-CMSN(2-)) anions, one water mol-ecule and three N atoms of three 4,4'-bi-pyridine ligands, with one 4,4'-bi-pyridine ligand situated on a centre of inversion.

Gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of Nav1.7 and p-ERK1/2 in DRG neurons.

It has been confirmed that gabapentin (GBP) induced a inhibition of the voltage-gated persistent sodium current in chronically compressed dorsal root ganglion (DRG) neurons. The persistent sodium current is found in excitable DRG neurons of painful diabetic neuropathy (PDN) rats where it is mediated by tetrodotoxin (TTX) sensitive sodium channels. Recently, many groups have used models of neurological disorder to explore the mechanism of GBP in neuropathic pain.

[Effect of gualou xiebai (GLXB) decoction on platelet-derived growth factor BB (PDGF-BB) expression in lungs from bleomycin A5 induced pulmonary fibrosis in rats].

Objective: To investigate the effect and mechanism of Gualou Xiebai (GLXB) decoction on pulmonary fibrosis.

Method: Pulmonary fibrosis was induced by bleomycin A5 in SD rats. Rats in treatment group were killed after being treated by GLXB by decoction daily for 28 days.