Acta Pharmacol Sin
February 2025
Cullin 4B (CUL4B) is the scaffold protein in the CUL4B-RING E3 ubiquitin ligase (CRL4B) complex. Loss-of-function mutations in the human CUL4B gene result in syndromic X-linked intellectual disability (XLID). In addition to intellectual disability, patients with CUL4B mutations exhibit epilepsy.
View Article and Find Full Text PDFInt J Comput Assist Radiol Surg
November 2011
Purpose: Realistic soft tissue deformation modeling and haptic rendering for surgical simulation require accurate knowledge of tissue material characteristics. Biomechanical experiments on porcine tissue were performed, and a reduced quasi-linear viscoelastic model was developed to describe the strain-dependent relaxation behavior of the arterial wall. This information is used in surgical simulation to provide a realistic sensation of reduction in strength when the user holds a virtual blood vessel strained at different levels.
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