Analysis of genetic diversity and genetic structure of Qinchuan cattle conservation population using whole-genome resequencing.

In the conservation of livestock and poultry resources, population genetic diversity and genetic structure of the conservation population are important factors affecting the effectiveness of conservation. In this study, whole-genome resequencing technology was used to detect genomic variation in 100 Qinchuan cattle (30 bulls and 70 cows). By analyzing population genetic diversity, runs of homozygosity (ROH) distribution features, kinship relationships, and family structure, the conservation effectiveness of Qinchuan cattle was comprehensively evaluated.

Clinical guideline on magnetically controlled capsule gastroscopy (2021 edition).

With the development and generalization of endoscopic technology and screening, clinical application of magnetically controlled capsule gastroscopy (MCCG) has been increasing. In recent years, various types of MCCG are used globally. Therefore, establishing relevant guidelines on MCCG is of great significance.

Impact of 9-Minute Withdrawal Time on the Adenoma Detection Rate: A Multicenter Randomized Controlled Trial.

Background & Aims: Although current quality indicators of colonoscopy recommend 6 minutes as the minimum standard for withdrawal time (WT), the impact of a WT longer than 6 minutes on neoplasia detection is unclear.

Methods: A multicenter randomized controlled trial involving 1027 patients was conducted from January 2018 to July 2019. Participants were randomly divided into a 9-minute (n = 514) and 6-minute (n = 513) WT group, and a timer was used to adjust the withdrawal speed.

Synthesis of 1-benzylisoindoline and 1-benzyl-tetrahydroisoquinoline through nucleophilic addition of organozinc reagents to ,-acetals.

A new approach to access 1-benzylisoindoline and 1-benzyl-tetrahydroisoquinoline has been developed through nucleophilic addition of organozinc reagents to N,O-acetals. A number of substituted organozinc reagents were amenable for this transformation, and the desired products were obtained with excellent yields. Moreover, Sc(OTf)3 proved to be an effective catalyst for the formation of 1-benzylisoindoline and 1-benzyl-tetrahydroisoquinoline using such nucleophilic addition.

Divergent synthesis of N-heterocyclic 1,6-enynes through a zinc-catalyzed decarboxylative A reaction.

A zinc-catalyzed decarboxylative A reaction of cyclic amino acids, α,β-unsaturated aldehydes and terminal alkynes has been developed. A series of functionalized N-heterocyclic 1,6-enynes have been successfully obtained with excellent regioselectivities through this novel approach. In addition, the utility of this straightforward process is demonstrated by the preparation of a polycyclic nitrogen-containing heterocyclic compound.

Synthesis of 1,4- and 1,5-Amino Alcohols via Nucleophilic Addition of Semicyclic ,-Acetal with Organozinc Reagents.

An efficient approach to access functionalized 1,4- and 1,5-amino alcohols has been developed through the nucleophilic addition of semicyclic ,-acetal with organozinc reagents. A number of substituted benzyl zinc reagents (including nitrile and ester substituted) could react with semicyclic ,-acetals and , affording the desired products - and - in good to excellent yields.

Asymmetric synthesis of (-)-sedacryptine through a diastereoselective Mannich reaction of N,O-acetals with ketones.

An efficient diastereoselective approach to access the 3-hydroxy-2,6-disubstituted piperidine scaffold 1 has been developed through the Mannich process involving N,O-acetal (2S,3R)-6 and ketones in excellent yield with high diastereoselectivity (dr > 99 : 1). In addition, the utility of this convenient one-pot process is demonstrated by the asymmetric synthesis of (-)-sedacryptine 3.

[Synthesis and fluorescence properties of the complexes [(Tb(x)Y(1-x)) (HL)L'Cl x 1/2H2O]].

By replacing a part of terbium ions with yttrium ions using doping method, a series of dinuclear complexes of 1,3,5-benzene tricarboxylic acid (H3BTC) and phenanthroline (phen) with different molar ratios of Tb3+ to Y3+ were synthesized in the present paper. Their elemental analysis, rare earth complexometric titration, molar conductivity, IR spectra and UV spectra were studied, and the contents of terbium and yttrium of three doped complexes were measured by a plasma emission spectrophotometer. Their chemical formula is inferred to be (Tb(x)Y(1-x)) (HL)L'Cl x 1/2H2O (x = 0.

A new ent-kaurane diterpenoid from Rabdosia pseudo-irrorata C. Y. Wu.

A new ent-kaurane diterpenoid, Pseurata H (1), was isolated from the aerial parts of Rabdosia pseudo-irrorata C. Y. Wu, along with three known compounds, Pseurata B (2), Pseurata C (3) and Pseurata F (4).

Fluorescent property of the Gd3+-doped terbium complexes and crystal structure of [Tb(TPTZ)(H2O)6]Cl3.3H2O.

The complex of Tb(TPTZ)Cl(3).3H(2)O was synthesized by adding the ethyl alcohol solution of TbCl(3) (1 mmol) to the solution of 2,4,6-tris-(2-pyridyl)-s-triazine(TPTZ, 1 mmol) with constant stirring. The solution which had been filtered was kept at the room temperature for 4 weeks, and then a kind of transparent crystal was formed.

[The clinical features and colonic epithelium AQP8 expression in diarrhea-irritable bowel syndrome].

Objective: To test the expression of AQP8 in ascending and descending colon mucosa of diarrhea-irritable bowel syndrome (D-IBS) patients and to study the relationship between IBS and AQP8 as well as the pathological mechanism for D-IBS.

Methods: The proximal ascending colon and the distal descending colon of 26 D-IBS sufferers were resected. Total RNA was purified from each sample of mucosa and AQP8 mRNA expression was analyzed with fluorescent quantitative RT-PCR.