Publications by authors named "Rui-Jing Gan"
Objectives: To look at the possible effect of IGF2R rs9456497 on cardiovascular risks in a long-lived population.
Methods: IGF-2R rs9456497 was genotyped by iMLDR for 496 long-lived Zhuang Chinese (90-107 y/o) and their offspring (n = 723, 60-75 y/o) and healthy controls (n = 611, 60-75 y/o). Association analyses were then conducted among genotypes and cardiovascular risks.
Article Synopsis
- The study investigates the relationship between BDNF Val66Met gene variant and metabolic risk factors like BMI, blood pressure, fasting plasma glucose, and lipid levels among long-lived individuals in Guangxi, China.
- 487 older individuals (aged 90+), their offspring (aged 60-77), and healthy controls (aged 60-75) were analyzed, finding no significant genetic distribution differences, but some correlations were noted in lipid levels and systolic blood pressure.
- Findings suggest that the BDNF 66Met variant may negatively impact blood pressure and lipid profiles in this population, potentially contributing to overall poor metabolic health.
Article Synopsis
- The Han Chinese, the largest ethnic group globally, consists of various branches, among which the Pinghua branch has been less studied but is believed to derive from ancient southern minorities.
- Genetic analyses of 470 samples show that Pinghua populations display high frequencies of certain Y chromosome haplogroups and mtDNA lineages similar to those found in nearby indigenous groups, indicating a closer relationship with southern minorities than with other Han branches.
- Overall, the findings suggest that while the Pinghua have adopted Han Chinese culture and language, their genetic roots trace back to southern minorities rather than the broader Han Chinese lineage.
[CT perfusion study of acute local cerebral infarction in rhesus monkeys].
Nan Fang Yi Ke Da Xue Xue Bao
May 2007
Objective: To explore the value of CT perfusion in early diagnosis and management of superacute local cerebral infarction in rhesus monkeys.
Method: Acute local cerebral infarction was induced in the rhesus monkeys during digital subtraction angiography (DSA) by introduction of pale thrombus prepared from autologous blood into the M1 branch of the middle cerebral artery (MCA). Plain CT scan and CT perfusion scanning were performed at different time points before and after DSA operation, and the results were analyzed in conjunction with the pathologic changes.