Uric acid is the final product of purine metabolism, and high levels in the body (hyperuricemia) can lead to various health issues due to oxidative stress and inflammation.
The presence of high uric acid affects the availability of nitric oxide in the body, which plays a crucial role in many physiological functions.
This review highlights the mechanisms by which high uric acid reduces nitric oxide levels and aims to improve understanding of the links between hyperuricemia and other metabolic diseases.