Paternal sleep deprivation induces metabolic perturbations in male offspring via altered LRP5 DNA methylation of pancreatic islets.

Diabetes and metabolic perturbation are global health challenges. Sleep insufficiency may trigger metabolic dysregulation leading to diabetes. However, the intergenerational transmission of this environmental information is not clearly understood.

Investigations of the local distortions and EPR parameters for Cu in xNa O-(30-x)K O-70B O (5 ≤ x ≤ 25 mol%) glasses.

The local distortions and electron paramagnetic resonance parameters for Cu in the mixed alkali borate glasses xNa O-(30-x)K O-70B O (5 ≤ x ≤ 25 mol%) are theoretically studied with distinct modifier Na O compositions x. Owing to the Jahn-Teller effect, the octahedral [CuO ] clusters show significant tetragonal elongation ratios p ~19% along the C axis. With the increase of composition x, the cubic field parameter Dq and the orbital reduction factor k exhibit linearly and quasi-linearly decreasing tendencies, respectively, whereas the relative tetragonal elongation ratio p has quasi-linearly increasing rule with some fluctuations, leading to the minima of g factors at x = 10 mol%.

Quantitative proteomics study of protective effects of grape seed procyanidin B2 on diabetic cardiomyopathy in db/db mice.

Diabetic cardiomyopathy is one of the major complications of diabetes mellitus. Oxidative stress appears to play a substantial role in cardiomyopathy. Grape seed procyanidin B2 (GSPB2) has been known as an anti-oxidant in treating diabetes mellitus; however, little is known about its effects and underlying mechanisms on diabetic cardiomyopathy.