Gut microbiota participates and remodels host metabolism: From treating patients to treating their gut flora.

In this editorial, we comment on Liu s article published in the recent issue of the . Biochemically and pathologically, Liu proved that the urate-lowering activity of leech total protein (LTP) was mainly attributed to the rectification of gut microbiota. Specifically, we noticed the change in and after LTP administration.

Ozone rectal insufflation mitigates chronic rapid eye movement sleep deprivation-induced cognitive impairment through inflammation alleviation and gut microbiota regulation in mice.

A range of sleep disorders has the potential to adversely affect cognitive function. This study was undertaken with the objective of investigating the effects of ozone rectal insufflation (O3-RI) on cognitive dysfunction induced by chronic REM sleep deprivation, as well as elucidating possible underlying mechanisms. O3-RI ameliorated cognitive dysfunction in chronic REM sleep deprived mice, improved the neuronal damage in the hippocampus region and decreased neuronal loss.

High level of TXNDC9 predicts poor prognosis and contributes to the NF-κB-regulated metastatic potential in gastric cancer.

Gastric cancer (GC) is the most frequent malignant tumor in the digestive system, with high metastasis potential and poor prognosis. This study aimed to investigate the prognostic value and biological function of thioredoxin domain-containing protein 9 (TXNDC9) in GC. The expression of TXNDC9 was analyzed based on The Cancer Genome Atlas (TCGA) database.

A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid-liquid phase separation to promote oncogenic YAP signaling.

Long noncoding RNAs (lncRNAs) are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development. Liquid-liquid phase separation (LLPS) occurs in a wide range of biological processes, while its role in signal transduction remains largely undeciphered. In this study, we uncovered a lipid-associated lncRNA, small nucleolar RNA host gene 9 (SNHG9) as a tumor-promoting lncRNA driving liquid droplet formation of Large Tumor Suppressor Kinase 1 (LATS1) and inhibiting the Hippo pathway.

[Control of Sludge Bulking Caused by Unknown Reason Through FeCl Coupled with Biochemical Methods].

Filamentous bulking could commonly influence effluent water quality in sewage treatment plants. Existing technologies are slowly effective, time consuming, and poorly adaptable. For now, enhancing organics substrates (COD) and dissolved oxygen (DO) concentration, adding FeCl into the reactor, and maintaining alternant aeration conditions are common methods to control filamentous bulking, but the effects of coupling techniques on the control of bulking are rarely reported.

Zearalenone induces apoptosis in bovine mammary epithelial cells by activating endoplasmic reticulum stress.

Zearalenone (ZEA) is a common mycotoxin produced by fungi within the genus Fusarium. However, few studies have examined the direct effects of the toxin on the mammary glands. In the present study, the effects of ZEA treatment on bovine mammary epithelial cells (MAC-T) from dairy cows were investigated.

Subacute Combined Degeneration, Pernicious Anemia and Gastric Neuroendocrine Tumor Occured Simultaneously Caused by Autoimmune Gastritis.

Subacute combined degeneration (SCD) is a relatively rare myelopathy mainly caused by vitamin B (VitB12) deficiency. There are many causes contributing to VitB12 deficiency. Autoimmune gastritis might lead to severe VitB12 malabsorption and in its advanced stage pernicious anemia (PA) may occur.

The role of repetitive transcranial magnetic stimulation (rTMS) in the treatment of cognitive impairment in patients with Alzheimer's disease: A systematic review and meta-analysis.

Background: Although repetitive transcranial magnetic stimulation (rTMS) has been considered a potentially effective treatment for cognitive impairment in patients with Alzheimer's disease (AD), previous studies have produced inconsistent results. The objective of this meta-analysis was to evaluate the effects of rTMS on cognitive function in patients with AD.

Methods: PubMed, EMBASE, Web of Science, MEDLINE and Cochrane Central Register of Controlled Trials (CENTRAL) were searched for relevant terms.

LncRNA CamK-A Regulates Ca-Signaling-Mediated Tumor Microenvironment Remodeling.

Cancer cells entail metabolic adaptation and microenvironmental remodeling to survive and progress. Both calcium (Ca) flux and Ca-dependent signaling play a crucial role in this process, although the underlying mechanism has yet to be elucidated. Through RNA screening, we identified one long noncoding RNA (lncRNA) named CamK-A (lncRNA for calcium-dependent kinase activation) in tumorigenesis.

LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism.

The Hippo pathway plays essential roles in organ size control and cancer prevention via restricting its downstream effector, Yes-associated protein (YAP). Previous studies have revealed an oncogenic function of YAP in reprogramming glucose metabolism, while the underlying mechanism remains to be fully clarified. Accumulating evidence suggests long noncoding RNAs (lncRNAs) as attractive therapeutic targets, given their roles in modulating various cancer-related signaling pathways.

The Protective Effects of Fasciotomy on Reperfusion Injury of Skeletal Muscle of Rabbits.

The authors aim to investigate protective effects of fasciotomy against ischemia reperfusion injury of skeletal muscle in rabbit and to compare the treatment effects of prereperfusion + fasciotomy and fasciotomy + postreperfusion against ischemia reperfusion injury of skeletal muscle. 24 healthy male Japanese white rabbits were randomly divided into 3 groups, and 4 hours' ischemia was established in these rabbits through surgery. Six hours' reperfusion was performed in group A; reperfusion + postfasciotomy was performed in group B; and prefasciotomy + reperfusion was performed in group C.

[Limestone and pyrite-limestone constructed wetlands for treating river water].

Polluted river water was treated with limestone and pyrite-limestone subsurface horizontal constructed wetlands. The aims were to know the performance of two wetlands on removal of common pollutants, especially nitrogen and phosphorus, and analyze the actions of these minerals. The relationship between hydraulic retention time and purification performance of two constructed wetlands was studied.

[Investigation of nitrobenzene removal by iron sulfide (FeS)].

The nitrobenzene removal performance by iron sulfide was investigated in batch experiments. The effects of different factors were studied. The results showed that the removal efficiency of nitrobenzene was 90% as initial nitrobenzene concentration was 0.

[Performance of nitrogen and phosphorus removal of sulfur/limestone autotrophic denitrification system].

In order to investigate the performance of nitrogen and phosphorus removal of the sulfur/limestone system from low C/N municipal sewage, a sulfur/limestone packed column reactor fed with synthetic wastewater, and operated in the way of anaerobic biological filter was constructed. The effects of HRT, initial concentration of phosphate, pH and temperature on nitrogen and phosphorus removal were studied. The results showed that with influent of NO3(-) -N 30 mg/L, PO4(3-) -P 15 mg/L, the optimal HRT value was 6 h, and removal rates of TN and phosphorus were 100% and 44.

[Non-nitrification pathway for NH4+ -N removal in pilot-scale drinking water biological processes].

The non-nitrification pathway for NH4+ -N removal in pilot-scale drinking water biological treatment processes and its possible mechanism were investigated through calculating N and DO stoichiometric balance. With more than 2 mg/L NH4+ -N in the influent, for the fluidized bed bioreactor (FBBR), the total of NH4+ -N, NO2(-) -N, NO3(-) -N in the influent was 0.91 mg/L higher than that in the effluent, and for the biofilter, its DO consumption was 2.

[Pilot-scale study on riparian Scirpus yagara Ohw zone improving water quality of river].

In one year polluted water was treated with Scirpus yagara Ohw to investigate its impact on river water quality in pilot scale test, and COD, NH4(+) -N, TP, turbidity and water temperature were tested. The results show that the Scirpus yagara Ohw gives better water quality in summer and autumn than in winter and spring. In summer, the Scirpus yagara Ohw zone removes 44.

[Pilot-scale study on riparian mixed plant zones treating polluted river water].

The polluted river water is treated with pilot-scale riparian zones of no aquatic plant, Vetiveria zizanioides + submerged plants, and weed+ Typha angustifolia L. + Phragmites communis. It is shown that the vegetation water zones are better than the no vegetation water zone and Vetiveria zizanioides + submerged plants zone is the best in improving water quality.