Transcriptome profiling of foxtail millet (Setaria italica) pollen and anther.

Pollen development and germination play a crucial role in the sexual reproduction of plants. This study analysis of transcriptional dynamics of foxtail millet pollen with other tissues and organs (ovule, glume, seedling and root) through RNA-sequencing revealed that a total of 940 genes were up-regulated in foxtail millet pollen. Based on this, we analyzed the genes involved in pollen tube growth of receptor kinases and small peptides, calcium signaling, small G proteins, vesicle transport, cytoskeleton, cell wall correlation, and transcription factors that are up-regulated in pollen.

Bio-Inspired Multiple Responsive NIR II Nanophosphors for Reversible and Environment-Interactive Information Encryption.

Inspired by the natural responsive phenomena, herein the multiple responsive persistent luminescent ZnGaGeO:Ni (ZGGO:Ni) nanoparticles with near-infrared  (NIR) II emission peak ≈1330 nm derived from the Ni doping through controlled synthesis based on hydrothermal method are obtained. The obtained NIR II persistent luminescent ZGGO:Ni can not only respond to temperature but also the specific solvent stimulus. The results demonstrate that the NIR II persistent luminescence intensity decreases in hydroxyl containing solvent such as water (HO) and ethyl alcohol (CHO), while the PL intensity remains in solvent without hydroxyl groups such as n-hexane (CH) and deuterated water (DO).

Circulating plasma derived exosomes from systemic lupus erythematosus aggravate lupus nephritis through miR-122-5p/FOXO3-mediated macrophage activation.

Systemic lupus erythematosus (SLE) is a chronic and systemic autoimmune disease characterized by dysregulation in both innate and adaptive immunity. Polarization of macrophages into M1/M2 macrophages affects the development of lupus. Exosomes-miRNA plays a crucial role in disease progression.

Boosting Formate Production in Electrocatalytic CO Reduction on Bimetallic Catalysts Enriched with In-Zn Interfaces.

We present an effective strategy for developing the dispersing strong-binding metal In on the surface of weak-binding metal Zn, which modulates the binding energy of the reaction intermediates and further facilitates the efficient conversion of CO to formate. The In-Zn interface (In-Zn2) benefits from the formation of active sites through favorable orbital interactions, leading to a Faradaic efficiency of 82.7% and a formate partial current density of 12.

Dynamics of Nanomotors Propelled by Enzyme Cascade Reactions.

Enzyme-powered nanomotors have attracted significant attention in materials science and biomedicine for their biocompatibility, versatility, and the use of biofuels in biological environments. Here, we employ a hybrid mesoscale method combining molecular dynamics and multi-particle collision dynamics (MD-MPC) to study the dynamics of nanomotors powered by enzyme reactions. Two cascade enzymes are constructed to be layered on the same surface of a Janus colloid, providing a confined space that greatly enhances reaction efficiency.

CO2 chemistry of Cu(100) regulated by Ni deposition and pressure.

Modification of copper-based catalysts by incorporating a second metal is prevailing in developing high-performance catalysts for CO2 hydrogenation. In particular, the insight into how the reaction is influenced is key to understanding the nature of the strategy. Herein, we show that both intermediates and reaction pathways of CO2 over Cu(100) are conspicuously regulated by Ni deposition and CO2 pressure.

Oral Targeted Delivery of Codonopsis Radix Polysaccharide via Succinyl -DHA Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis.

Introduction: Ulcerative colitis (UC) is a chronic intestinal disease characterized by spleen-lung qi deficiency and dampness-pathogenic obstruction. Although there are various treatment options available, patients frequently encounter significant drug-related side effects. Previous studies have shown the potential of A (CPA) in treating UC, but their limited bioavailability has restricted their clinical use.

Facile Synthesis of Bamboo Biochar for Efficient Adsorption of Quinolone Antibiotics: Effects and Mechanisms.

The harmful effects of quinolone antibiotics on ecology and human health have attracted widespread attention. In this study, bamboo biochar synthesized at different pyrolysis temperatures was used to remove quinolone antibiotics (moxifloxacin (MFX), ciprofloxacin (CIP), and ofloxacin (OFLX) as models). The pyrolysis temperature of 700 °C led to a high pore volume and average pore size of biochar.

Deciphering the temporal transcriptional landscape of human fetal leptomeninges.

The leptomeninges play a pivotal role in the central nervous system (CNS), serving both as a barrier and as a conduit for fluid and cellular transport. Despite their critical functions, our understanding of leptomeningeal development and maturation during human embryogenesis remains limited. This study seeks to bridge this gap.

Low-and intermediate-grade lateral sinus dural arterio venous fistulas: Factors affecting the outcome of endo vascular treatment over 18-year experience in a high-volume neurovascular center.

Background And Purpose: Lateral sinus dural arteriovenous fistulas (LS-DAVFs) carry a higher rate of recurrence after endovascular treatment (EVT). Our objective was to investigate the independent predictors of recurrence and unfavorable functional outcome of low-and intermediate-grade LS-DAVFs after EVT.

Materials And Methods: Retrospectively reviewed our database of prospectively collected information for all patients with low and intermediate-grade LS-DAVFs that underwent EVT from May 2004 to December 2021.

Framework nucleic acid strategy enables closer microbial contact for programming short-range interaction.

Programming precise and specific microbial intraspecies or interspecies interaction would be powerful for microbial metabolic regulation, signal pathway mechanism understanding, and therapeutic application. However, it is still of great challenge to develop a simple and universal method to artificially encode the microbial interactions without interfering with the intrinsic cell metabolism. Here, we proposed an extensible and flexible framework nucleic acid strategy for encoding the specific and precise microbial interactions upon self-assembly.

Branched-chain amino acids deficiency promotes diabetic cardiomyopathy by activating autophagy of cardiac fibroblasts.

More than half of the patients with type II diabetes mellitus (T2D) develop diabetic cardiomyopathy (DCM). Glycemic control alone cannot effectively prevent or alleviate DCM. Herein, we concentrated on the variations in levels of metabolites between DCM and T2D patients without cardiomyopathy phenotype.

Multiomics unraveled that gibberellin signaling underlies adaptation of rice to ciprofloxacin stress: Calling for concerns on the adverse effects of pharmaceutical residues in water during agricultural irrigations.

Residual concentrations of antibiotics in water can reach ng mL - µg mL levels, which pose high risks to crops during irrigation; however, the interactions between rice and antibiotics, as well as the defense mechanisms of rice at their early growth phase remain unclear. In this study, we investigated the uptake dynamics of a ubiquitously found antibiotic, ciprofloxacin (CIP) at 0.1, 1, 6.

Gender-specific inflammatory burden and headache risk in youth: a NHANES analysis.

Background: Headaches are a common and often debilitating condition among youth. The Inflammatory Burden Index (IBI), a simple surrogate marker of systemic inflammation, has been linked to various diseases. However, evidence for its relationship with headaches, particularly in youth, is lacking.

Application of intraoral scanning registration implant robot in dental implant surgery.

Objectives: This paper aims to investigate the application of intraoral scanning and cone beam computed tomography (CBCT) registration implant robot in dental implant surgery.

Methods: The data of 40 cases with dental defect of robot-assisted implantation from November 2023 to May 2024 were retrospectively analyzed. Before the operation, the intraoral scan data and CBCT data of the positioning markers were automatically fused with the initial CBCT images, and the registration error was calculated.

Exploring the diversity of sexual acts in Chinese men who have sex with men and its impacts on the risk of HIV and sexually transmitted infections.

Objectives: High-risk sexual behaviour contributes to sexually transmitted infections (STIs), but the diversity of sexual acts in men who have sex with men (MSM) was understudied. We aimed to identify the diversity of sexual acts in Chinese MSM and its impacts on HIV/STI risk.

Study Design: Cross-sectional study.

Coaxial Electrospun Nanofibrous Membranes as Dual-Functional Biomimetic Tendon Sheath for Tendon Repair and Anti-Peritendinous Adhesion.

Tendon injuries often exhibit limited healing capacity, frequently complicated by peritendinous adhesion, posing a substantial challenge in clinical tendon repair. Although present biomaterial-based membranes offer a promising strategy for tendon treatment, their clinical application is hindered by inflammation-induced adhesion. Herein, this study presents a dual-functional biomimetic tendon sheath based on a coaxial electrospun nanofibrous membrane for enhancing tendon repair and simultaneously preventing peritendinous adhesion.

IL7 as a Risk Factor for Prostate Cancer: Implications for T Cell Apoptosis and Infiltration in the Tumor Microenvironment.

Background: Prostate cancer's complex interplay with the immune microenvironment prompted an investigation into immune-related pathogenic mechanisms and potential therapeutic targets.

Methods: Within the GSE176031 data set, Seurat meticulously dissected single-cell profiles from radical prostatectomy patients. Leveraging CellMarker and SingleR cell identities were precisely annotated.

Light-Mediated Interconversion between a Foldamer and a Self-Replicator.

Self-replicating molecules and well-defined folded macromolecules are of great significance in the emergence and evolution of life. How they may interconnect and affect each other remains largely elusive. Here, we demonstrate an abiotic system where a single building block can oligomerize to yield either a self-replicating molecule or a foldamer.