Publications by authors named "Rui Yang Liu"
[Statins enhance anti-tumor effect of suberoylanilide hydroxamic acid on human non-small cell lung carcinoma cells].
Zhejiang Da Xue Xue Bao Yi Xue Ban
September 2015
Objective: To evaluate the anti-tumor effect of the combination of suberoylanilide hydroxamic acid(SAHA) with statins(lovastatin or simvastatin) on non-small cell lung carcinoma(NSCLC) cells.
Methods: Human NSCLC A549 cells were treated with SAHA in combination of lovastatin or simvastatin. The cell growth was analyzed by SRB method, and the apoptosis of A549 cells was assessed by flow cytometer.
Article Synopsis
- The study focuses on the transcriptional regulatory region of the FAD2 gene in Brassica napus, specifically examining a gene labeled BnFAD2A5-1 found on chromosome A5.
- It was discovered that the gene includes a 1,192 bp intron in its 5'-untranslated region (5'-UTR) that actually has promoter activity, influencing the gene's expression.
- Through deletion analysis, researchers identified key regions of the promoter necessary for high transcription levels, as well as factors like light, low temperature, and ABA that induce the expression of BnFAD2 transcripts.