NCAM1 modulates the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary hypertension.

Background: Pulmonary hypertension (PH) is a malignant vascular disease characterized by pulmonary arterial remodeling. Neural cell adhesion molecule 1 (NCAM1) is a cell surface glycoprotein that is involved in a variety of diseases, including cardiovascular disease. However, the role of NCAM1 in PH remains underexplored.

Genome-Wide Identification and Expression Profiling Analysis of the CCT Gene Family in and .

CCT family genes play crucial roles in photoperiodic flowering and environmental stress response; however, there are limited reports in species with considerable edible and medicinal value. In this study, we conducted genome-wide characterization and expression profiling analysis of the CCT gene family in two species: tomato ( L.) and eggplant ( L.

Spatial and temporal evolution and factors influencing soil aggregate stability in the riparian zone during exposure: A case study of the water-level fluctuation zone of the Three Gorges Reservoir, China.

The water-level fluctuation zone (WLFZ) is a unique riparian region that forms in response to the operation of the reservoir. The periodic submersion-exposure conditions severely affect the properties of soil and vegetation, thus also change the spatial and temporal development of soil aggregate stability. Nonetheless, the changes in both space and time concerning soil aggregate stability and the factors influencing it during the exposure period in the WLFZ are still unclear.

Bilateral superselective adrenal artery embolization for bilateral primary aldosteronism: a novel approach in an efficacy and safety proof-of-principle trial.

Superselective adrenal artery embolization (SAAE) offers a novel approach for treating primary aldosteronism (PA). In this study, we aimed to assess the efficacy and safety of SAAE for the treatment of PA based on the lateralization results obtained from adrenal vein sampling (AVS).In this prospective study, we enrolled 40 patients with PA who underwent SAAE.

Safety and efficacy of bilateral superselective adrenal arterial embolization for treatment of idiopathic hyperaldosteronism: a prospective single-center study.

Objective: This study aimed to assess the efficacy and safety of bilateral superselective adrenal arterial embolization (SAAE) in patients with bilateral idiopathic hyperaldosteronism (IHA), a subtype of PA.

Methods: Ninety-eight patients with bilateral IHA underwent bilateral SAAE between August 2022 and August 2023. Sixty-eight patients were followed up for up to 12 months.

Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis.

Nonalcoholic fatty liver disease (NAFLD) is a serious threat to public health, but its underlying mechanism remains poorly understood. In screening important genes using Gene Importance Calculator (GIC) we developed previously, ribosomal modification protein rimK-like family member A (RIMKLA) was predicted as one essential gene but its functions remained largely unknown. The current study determined the roles of RIMKLA in regulating glucose and lipid metabolism.

PANX1-mediated ATP release confers FAM3A's suppression effects on hepatic gluconeogenesis and lipogenesis.

Background: Extracellular adenosine triphosphate (ATP) is an important signal molecule. In previous studies, intensive research had revealed the crucial roles of family with sequence similarity 3 member A (FAM3A) in controlling hepatic glucolipid metabolism, islet β cell function, adipocyte differentiation, blood pressure, and other biological and pathophysiological processes. Although mitochondrial protein FAM3A plays crucial roles in the regulation of glucolipid metabolism via stimulating ATP release to activate P2 receptor pathways, its mechanism in promoting ATP release in hepatocytes remains unrevealed.

Release dynamics, risk evolution and driving mechanisms of heavy metals in superalkaline fly ash co-disposed by MSW landfill.

Fly ash from waste incineration is growing rapidly and has become a global problem. Landfill is the main treatment method, but the release behavior of ultra-alkaline fly ash needs further study. In this study, the release pattern of heavy metals from fly ash, the long-term risk after seepage, and the main control mechanisms were explored by indoor simulation experiments and process simulation modeling.

Release potential, neglected leakage and reduction countermeasures of COD and Ammonia in MSWLs.

In order to eliminate the impact of the industrial revolution on the environment and improve the water ecological environment, pollutant discharge reduction is imperative. With the acceleration of global discharge reduction process, the huge pollutant release potential and potential environmental effects of municipal solid waste landfills gradually appear, but its release amount and intensity have not been quantitatively revealed. We propose a coupling method of parameter stochastic simulation and physical process model simulation to estimate the hidden leakage of large-scale regional municipal solid waste landfills, and provide a methodology for estimating the hidden leakage of landfills in other countries and even in the whole world by taking China, which has the largest amount of waste generation among developing countries, as an example.

Uric acid and evaluate the coronary vascular stenosis gensini score correlation research and in gender differences.

Background And Aims: Recent studies have shown that the negative effect of uric acid (UA) on coronary arteries determines the severity of atherosclerotic disease. This study aims to explore the relationship between serum UA level and Gensini score, which reflects the severity of coronary artery disease.

Methods: A total of 860 patients with suspected coronary heart disease who were admitted to hospital due to angina pectoris or myocardial ischemia related symptoms and received coronary angiography were selected.

BTSC-TNAS: A neural architecture search-based transformer for brain tumor segmentation and classification.

Glioblastoma (GBM), isolated brain metastasis (SBM), and primary central nervous system lymphoma (PCNSL) possess a high level of similarity in histomorphology and clinical manifestations on multimodal MRI. Such similarities have led to challenges in the clinical diagnosis of these three malignant tumors. However, many existing models solely focus on either the task of segmentation or classification, which limits the application of computer-aided diagnosis in clinical diagnosis and treatment.

Diagnostic performance of resting full-cycle ratio in identifying coronary lesions causing myocardial ischaemia: a meta-analysis.

Background: The resting full-cycle ratio (RFR), a new non-congestive resting index, is commonly used for physiological evaluations of coronary arteries.

Aims: This study aims to evaluate the accuracy of RFR in detecting coronary artery stenosis with hemodynamic significance using fractional flow reserve (FFR) as the reference standard.

Methods: Using 'RFR, resting full-cycle ratio' as the search term, we searched PubMed, Embase, Cochrane Library, and Web of Science databases, screening the literature according to the inclusion and exclusion criteria.

Development of a novel fluorescent aptasensor based on the interaction between hexagonal β-Co(OH) nanoplates and nitrogen-doped carbon dots for ultrasensitive detection of patulin.

There is an urgent need to develop an economical and convenient method for the ultrasensitive detection of patulin (PAT), a mycotoxin that can potentially harm human health when it is found in fruits and their derivatives. In this study, we have developed a novel fluorescent aptasensor that utilizes nitrogen-doped carbon dots (N-CDs) as the fluorescent donor and hexagonal β-Co(OH) nanoplates as the fluorescent acceptor. N-CDs were synthesized through the hydrothermal method, resulting in spherical particles with a diameter of 7.

Development and validation of a radiomics-based prediction pipeline for the response to stereotactic radiosurgery therapy in brain metastases.

Objectives: The first treatment strategy for brain metastases (BM) plays a pivotal role in the prognosis of patients. Among all strategies, stereotactic radiosurgery (SRS) is considered a promising therapy method. Therefore, we developed and validated a radiomics-based prediction pipeline to prospectively identify BM patients who are insensitive to SRS therapy, especially those who are at potential risk of progressive disease.

Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation.

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide; however, the underlying mechanisms remain poorly understood. FAM3D is a member of the FAM3 family; however, its role in hepatic glycolipid metabolism remains unknown. Serum FAM3D levels are positively correlated with fasting blood glucose levels in patients with diabetes.

Increased plasma expression of a disintegrin and metalloproteinase with thrombospondin motifs like 4 in patients with idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.

Idiopathic pulmonary arterial hypertension (IPAH) and chronic thromboembolic pulmonary hypertension (CTEPH) can result in right heart failure. We aimed to evaluate the plasma protein levels of a disintegrin and metalloproteinase with thrombospondin motifs like 4 (ADAMTSL4) and its relationship with IPAH and CTEPH. Plasma ADAMTSL4 protein levels were measured using proteomics analysis in eight patients with IPAH and nine healthy controls.

Effects of adjuvant application of corticosteroid and ozone after ultrasound-guided puncture and lavage for the treatment of rotator cuff calcific tendinitis: study protocol for a non-inferiority randomized controlled trial.

Background: Steroid injection after percutaneous irrigation of calcific deposits is a common method for the treatment of rotator cuff calcific tendinitis (RCCT). However, steroids may prevent calcification resorption and cause potentially irreversible damage to tendons. Recent studies have confirmed the positive effects of ozone injection in shoulder tendinopathies, but no RCCTs have been reported.

A meta-analysis of the relationship between circulating microRNA-155 and coronary artery disease.

Objective: Coronary artery disease (CAD) is a leading cause of death worldwide. Many studies in China and abroad have reported an association between the expression level of microRNA-155 and CAD; however, the results remain controversial. We aimed to comprehensively investigate this association based on a meta-analysis.

FAM3A Deficiency - Induced Mitochondrial Dysfunction Underlies Post-Infarct Mortality and Heart Failure.

Mitochondrial protein sequence similarity 3 gene family member A (FAM3A) plays important roles in the electron transfer chain, while its functions in the heart are still unknown. This study aims to explore the roles and mechanisms of FAM3A after myocardial infarction (MI). FAM3A-deficient (Fam3a) mice were implemented with MI injury and showed lower survival rates at 4 weeks as well as decreased cardiac systolic function.

Theory, framework, and methodology for physical lifespan prediction of hazardous waste landfills.

Landfill is a predominant method for hazardous waste disposal in both developed and emerging economies due to simple disposal technology and wide applicability. The prediction of landfill lifespan during the design stage provides support for environmental management of hazardous waste landfill (HWL) and technical support for the implementation of national standards. It also provides guidance for necessary responses after the lifespan expires.

BTMF-GAN: A multi-modal MRI fusion generative adversarial network for brain tumors.

Image fusion techniques have been widely used for multi-modal medical image fusion tasks. Most existing methods aim to improve the overall quality of the fused image and do not focus on the more important textural details and contrast between the tissues of the lesion in the regions of interest (ROIs). This can lead to the distortion of important tumor ROIs information and thus limits the applicability of the fused images in clinical practice.

A novel cascade machine learning pipeline for Alzheimer's disease identification and prediction.

Introduction: Alzheimer's disease (AD) is a progressive and irreversible brain degenerative disorder early. Among all diagnostic strategies, hippocampal atrophy is considered a promising diagnostic method. In order to proactively detect patients with early Alzheimer's disease, we built an Alzheimer's segmentation and classification (AL-SCF) pipeline based on machine learning.

Self-standing 2D/2D CoO@FeOOH nanosheet arrays as promising catalysts for the oxygen evolution reaction.

The rational design of a highly efficient oxygen evolution reaction (OER) is crucial for the practical applications of water electrolysis. Herein, a hybrid CoO@FeOOH/NF electrode was fabricated by loading FeOOH sheets on the surface of CoO nanosheet arrays a newly developed chemical deposition protocol. The decoration of FeOOH on CoO nanosheet arrays not only endows a strong electronic interaction between the two components but also offers sufficient active sites for the OER process.

Spatiotemporal difference of leachate production and its impact on the development and dynamics of LCS clogging.

Due to the complexity of industrial solid waste, heavy metals and organics can be enriched in leachate. While leachate is difficult to handle, it can also cause clog of the leachate collection system (LCS), increasing the risk of leakage. Therefore, it is necessary to study the clogging process of LCS in industrial solid waste landfills (ISWLs).