Case Report: Persistent toxic reactions in a toddler with a negative blood cantharidin toxicology test.

Cantharidin is a potent natural toxin and has been used in traditional Chinese medicine to treat cancers and various ailments such as rabies or psoriasis. However, improper use of cantharidin can easily lead to poisoning. Despite there is an increasing amount of literature on the toxic mechanisms of cantharidin, there is still limited knowledge about the disease progression, toxic reactions and toxic blood concentrations in children with cantharidin poisoning.

Function Identification of a Lactonase Gene Involved in Producing Urolithin A of FUA033.

This study aimed to identify the lactonase gene in FUA033 that facilitates the conversion of ellagic acid into urolithin A. Lactonase gene candidates were identified genome analysis. A series of overexpression, knockout, and complementation strains of these candidate genes were subsequently generated.

Tailoring Electronic and Magnetic Properties of YcoO via Anharmonic Phononic Coupling and Vector Vortex Beam Interaction.

The ability to dynamically manipulate the optoelectronic and magnetic properties in functional materials under nonequilibrium conditions is essential for the advancement of quantum technologies and energy-related applications. Here, we demonstrate a novel method to regulate the optoelectronic and magnetic properties of YCoO, a representative perovskite oxide, using ultrafast vortex laser pulses coupled with nonlinear phonon interactions. Vortex light, characterized by its helical phase front and topological charge, allows selective excitation of infrared phonon modes, enabling anisotropic lattice distortions and precise modulation of material properties.

The experience and role of dissociation in psychosis following developmental trauma: A systematic review.

Developmental trauma (DT), defined as abuse or neglect before age 18, is linked with elevated risk and poorer outcomes in psychosis. This systematic review aimed to elucidate the relationship between DT and dissociation in psychosis and discern the potential mediating role of dissociation in the link between DT and psychotic manifestations. Our study protocol was pre-registered with PROSPERO (CRD42022330026).

Dopant-Regulated Piezocatalysts Evoke Sonopiezoelectric and Enzymatic PANoptosis for Synergistic Cancer Therapy.

Piezocatalyst-enabled sonopiezoelectric therapy offers noninvasive treatment with high spatiotemporal selectivity, yet existing piezocatalysts are limited by suboptimal efficacy, cancer cell resistance to oxidative stress, and biosafety concerns. Here, hafnia (HfO), one of the only few FDA-approved inorganic nanomaterials for clinical trials, is identified as a promising piezocatalyst with high translational potential for sonopiezoelectric and enzymatic PANoptosis-boosted nanocatalytic therapy. Specifically, engineered transition metal-substituted HfO nanocatalysts are synthesized to optimize piezoelectric and enzyme-mimicking activities.

Dissecting biological heterogeneity in major depressive disorder based on neuroimaging subtypes with multi-omics data.

The heterogeneity of Major Depressive Disorder (MDD) has been increasingly recognized, challenging traditional symptom-based diagnostics and the development of mechanism-targeted therapies. This study aims to identify neuroimaging-based MDD subtypes and dissect their predominant biological characteristics using multi-omics data. A total of 807 participants were included in this study, comprising 327 individuals with MDD and 480 healthy controls (HC).

Genome-wide analysis of Q binding reveals a regulatory network that coordinates wheat grain yield and grain protein content.

Wheat is an important cereal crop used to produce diverse and popular food worldwide because of its high grain yield (GY) and grain protein content (GPC). However, GY and GPC are usually negatively correlated. We previously reported that favorable alleles of the wheat domestication gene Q can synchronously increase GY and GPC, but the underlying mechanisms remain largely unknown.

Cobalt-Cluster-Triggered Exfoliation for Ultrathin Metal-Covalent Organic Framework Nanosheets.

Metal-covalent organic frameworks (MCOFs), an emerging type of porous material, have the combined advantages of metal-organic frameworks (MOFs) and covalent organic frameworks (COFs). Of particular interest are MCOF nanosheets with two-dimensional morphology, whose fully exposed active sites and quasi-molecular size are expected to exhibit maximum functionality for a wide range of applications. However, due to their strong interlayer coupling and the potential structural damage during the synthesis process, the preparation of MCOF nanosheets has rarely been reported.

Oviposition Deterrents from Extracts of Against Potato Tuber Moth Zeller (Lepidoptera: Gelechiidae).

The potato tuber moth is a serious boring pest of potato. An integrated ecological approach to sustainable pest management is necessary for the control of this species. This study investigated the effects of minced leaves and plant extracts of on the oviposition behavior of PTM females.

Persistent organic pollutants and plasma microRNAs: A community-based profiling analysis.

Background: Whether exposure to persistent organic pollutants (POPs) may incur microRNAs (miRNAs) dysregulation remains largely unclear.

Objectives: We aim to identify the miRNA signature and related pathways of low-level POPs exposure in a community-based population.

Methods: We used general linear regression to model the association of POPs with plasma miRNAs, adjusting for age, gender, smoking, alcohol consumption, body mass index, triglyceride, and total cholesterol levels.

Circulating Tumor Microenvironment in Metastasis.

Activation of invasion and metastasis is a central hallmark of cancer, contributing to the primary cause of death for cancer patients. In the multistep metastatic process, cancer cells must infiltrate the circulation, survive, arrest at capillary beds, extravasate, and form metastatic clones in distant organs. However, only a small proportion of circulating tumor cells (CTCs) successfully form metastases, with transit of CTCs in the circulation being the rate-limiting step.

Analysis of acute non-pharmaceutical toxic exposures in children: a 5-year retrospective study.

Objective: This study aims to systematically analyze the epidemiological characteristics, clinical interventions and outcomes of children with acute non-pharmaceutical toxic exposures.

Methods: This retrospective study included all children with acute non-pharmaceutical toxic exposure admitted to the emergency department of the Capital Institute of Pediatrics between January 1, 2019, and December 31, 2023. Eligible patients were triaged into red, yellow, and green groups according to their severity condition.

Wavelet-Based Compression Method for Scale-Preserving SWIR Hyperspectral Data.

Purpose: Hyperspectral imaging (HSI) collects detailed spectral information across hundreds of narrow bands, providing valuable datasets for applications such as medical diagnostics. However, the large size of HSI datasets, often exceeding several gigabytes, creates significant challenges in data transmission, storage, and processing. This study aims to develop a wavelet-based compression method that addresses these challenges while preserving the integrity and quality of spectral information.

Predicting cell properties with AI from 3D imaging flow cytometer data.

Predicting the properties of tissues or organisms from the genomics data is widely accepted by the medical community. Here we ask a question: can we predict the properties of each individual cell? Single-cell genomics does not work because the RNA sequencing process destroys the cell, not allowing us to verify our predictions. To test the hypothesis, we investigate the approach of using AI to analyze single-cell images obtained from a 3D imaging flow cytometer.

A PTT-Induced Feed-Back Carbon Nanosystem for Enhanced Breast Cancer Therapy by Extracellular Matrix Remodeling.

In the treatment of breast cancer, the dense extracellular matrix (ECM) severely impedes drug delivery and immune cell infiltration, resulting in poor therapeutic effects. Photothermal therapy (PTT) has achieved promise in preclinical breast cancer studies. However, in tumor immunogenic cell death (ICD) induced by PTT, immune cells are almost confined around the tumor periphery due to the ECM, which weakens the immune response.

Early assessment and treatment of ventricular remodeling in vivo via a targeted ultrasonic molecular probe loaded with oxygen and cholecystokinin.

Early identification and treatment of ventricular remodeling (VR) are crucial for delaying the progression of heart failure after myocardial infarction. This study aims to develop a dual-responsive phase-shift molecular probe loaded with a cholecystokinin octapeptide (CCK-8) and oxygen, which will provide a new integrated scheme for the assessment and treatment of VR. Biocompatible phospholipid shells were utilized to encapsulate CCK-8 and perfluoropentane (PFP), an efficient oxygen carrier.

Preliminary Study of a Novel Ga-Labeled Probe Targeting Neuropilin-1 for Tumor Diagnosis.

Neuropilin-1 (NRP-1), a transmembrane protein related to tumor progression and invasion, presents potential as a prospective biomarker for tumor diagnosis and therapy. Positron emission tomography (PET) is acknowledged as an ideal modality for accurately monitoring NRP-1 expression due to its superior sensitivity and resolution. In this study, a novel peptide-based PET imaging probe, [Ga]Ga-DOTA-NEP, was successfully developed for specifically visualizing NRP-1 expression in tumors.

A frequency attention-embedded network for polyp segmentation.

Gastrointestinal polyps are observed and treated under endoscopy, so there presents significant challenges to advance endoscopy imaging segmentation of polyps. Current methodologies often falter in distinguishing complex polyp structures within diverse (mucosal) tissue environments. In this paper, we propose the Frequency Attention-Embedded Network (FAENet), a novel approach leveraging frequency-based attention mechanisms to enhance polyp segmentation accuracy significantly.

Stepwise Coordination Engineering of Pt/Au Dual Catalytic Sites with Enhanced Electrochemical Activity and Stability.

Dual-site catalysts hold significant promise for accelerating complex electrochemical reactions, but a major challenge remains in balancing high loading with precise dual-site architecture to achieve optimal activity, stability, and specificity simultaneously. Herein, a strategy of stepwise targeted coordination engineering is introduced to co-anchor Pt single atoms (Pt, 1.41 wt.

The success rate of infrazygomatic mini-implants placed with and without surgical guides: a historical control study.

Background: To improve the success rate of mini-implants, some surgical guides have been developed through digital technologies to achieve three-dimensional (3D) guided mini-implants insertion. However, there is no a surgical guide which can be applied for the insertion of infrazygomatic mini-implant. In this study, we introduced a two-trajectories surgical guide and investigated the success rate of infrazygomatic mini-implants under the guidance of the template.

Associations of Short-Term Ozone Exposure With Hypoxia and Arterial Stiffness.

Background: Epidemiological studies reported associations between ozone (O) exposure and cardiovascular diseases, yet the biological mechanisms remain underexplored. Hypoxia is a shared pathogenesis of O-associated diseases; therefore, we hypothesized that O exposure may induce changes in hypoxia-related markers, leading to adverse cardiovascular effects.

Objectives: This study aimed to investigate associations of short-term O exposure with hypoxic biomarkers and arterial stiffness.

Joint Physical-Psychosocial Frailty and Risks of All-Cause and Cause-Specific Premature Mortality.

Background: The importance of integrating physical and psychosocial factors in assessing frailty -health outcomes has been increasingly acknowledged, while the related evidence is lacking. We sought to investigate the associations of joint physical-psychosocial frailty with risk of premature mortality and evaluate the relative importance of individual physical and psychosocial factors.

Design: A total of 381,295 participants with no history of cancer or cardiovascular disease (CVD) were recruited from the UK Biobank cohort.

Relative contributions of climate and grazing to forage supply in the Yellow River source area.

Grassland ecosystems, critical for ecosystem services like forage supply, face threats from climate change and grazing pressure. This study investigates the spatiotemporal dynamics of forage supply and grazing intensity in the Yellow River Source Area (YRSA) from 2000 to 2020, focusing on the relative contributions of climate factors and grazing. Our result revealed that forage supply exhibited a southeast-to-northwest decline and increased slightly overall, with variability among grassland types.

Electrospun meshes for abdominal wall hernia repair: Potential and challenges.

Surgical meshes are widely used in abdominal wall hernia repairs. However, consensus on mesh treatment remains elusive due to varying repair outcomes, especially with the introduction of new meshes, posing a substantial challenge for surgeons. Addressing these issues requires communicating the features of emerging candidates with a focus on clinical considerations.