The comparative study of the efficacy of recombinant human brain natriuretic peptide combined with vasoactive medications for elderly patients with heart failure and hypotension receiving injections.

Background: Heart failure (HF) in elderly patients with concurrent hypotension presents a therapeutic challenge due to limited standard HF therapies' applicability. Recombinant human brain natriuretic peptide (rhBNP) and vasoactive medications have shown potential in HF management, but their combined efficacy in elderly patients with HF and hypotension remains understudied.

Methods: This retrospective cohort study included elderly HF patients with hypotension who received rhBNP alone (Group A, n = 68), rhBNP with dobutamine (Group B, n = 74), or rhBNP with dopamine (Group C, n = 71).

Adaptive CT XIGA Using LR B-Splines for Efficient Fracture Modeling.

This paper presents a novel adaptive crack-tip extended isogeometric analysis (adaptive CT XIGA) framework based on locally refined B-splines (LR B-splines) for efficient and accurate fracture modeling in two-dimensional solids. The XIGA method facilitates crack modeling without requiring the specific locations of crack faces and enables crack propagation simulation without remeshing by employing localized enrichment functions. LR B-splines, as an advanced extension of B-splines and NURBS, offer high-order continuity, precise geometric representation, and local refinement capabilities, thereby enhancing computational accuracy and efficiency.

Cost-effectiveness of universal genetic screening for familial hypercholesterolemia in young adults aged 18-40 years in China.

Background: Mortality from familial hypercholesterolemia (FH) remains high due to late diagnosis, and the rate of timely diagnosis remains low (< 10% globally and < 1% in China). Early screening and treatment could significantly reduce mortality risk, especially among young adults. This study aims to evaluate the cost-effectiveness of universal genetic screening of young adults aged 18-40 years compared to universal cholesterol screening or current passive screening strategies (opportunistic cholesterol screening and genetic cascade testing) for FH in China.

Trastuzumab rezetecan, a HER2-directed antibody-drug conjugate, in patients with advanced HER2-mutant non-small-cell lung cancer (HORIZON-Lung): phase 2 results from a multicentre, single-arm study.

Background: Trastuzumab rezetecan (also known as SHR-A1811) is a novel antibody-drug conjugate consisting of a humanised HER2-directed monoclonal antibody, cleavable tetrapeptide-based linker, and DNA topoisomerase I inhibitor. In the phase 1 portion of this phase 1/2 study, trastuzumab rezetecan showed preliminary anti-tumour activity and a favourable safety profile in patients with HER2-mutant non-small-cell lung cancer (NSCLC). We present phase 2 results from the study, which aimed to further evaluate the activity and safety of trastuzumab rezetecan at the recommended dose.

Factors affecting treatment adherence among patients with hypertension based on the PRECEDE model: A cross-sectional study from a delay discounting perspective.

Background: Hypertension is a significant global public health concern, and research shows that treatment adherence plays an important role in hypertension control. This study incorporated a novel factor in behavioral economics, delay discounting, into the predisposing factors within the PRECEDE model to explore the factors influencing adherence to treatment of patients with hypertension.

Design: This cross-sectional study was conducted in Jiangsu Province, China, in 2023 and included 1,123 patients with hypertension.

SMARCA4 Deficiency in Lung Cancer: From Signaling Pathway to Potential Therapeutic Targets.

SMARCA4-deficient lung cancer, including thoracic SMARCA4-deficient undifferentiated tumors and SMARCA4-deficient nonsmall-cell lung carcinomas, is a rare and aggressive disease characterized by rapid progression and poor prognosis. This cancer was identified as a distinct entity with specific morphologic and molecular features in the 2021 WHO Classification of Thoracic Tumors. Molecular alterations in SMARCA4 are specific to this type of lung cancer.

Channel Code-Book (CCB): Semantic Image-Adaptive Transmission in Satellite-Ground Scenario.

Satellite-ground communication is a critical component in the global communication system, significantly contributing to environmental monitoring, radio and television broadcasting, aerospace operations, and other domains. However, the technology encounters challenges in data transmission efficiency, due to the drastic alterations in the communication channel caused by the rapid movement of satellites. In comparison to traditional transmission methods, semantic communication (SemCom) technology enhances transmission efficiency by comprehending and leveraging the intrinsic meaning of information, making it ideal for image transmission in satellite communications.

Analysis of Toxic Elements Pollution Sources and Crop Health Risks in Soil of Typical Thallium Mining Area.

The investigation focused on Tl, Hg, As, and Sb as the targeted contaminants in the soil surrounding a thallium mining region in southwestern China. Potential sources of toxic elements were identified using correlation analysis and principal component analysis. By interpreting the results of correlation and principal component analysis, the potential sources of Tl, Hg, As, and Sb were identified to include the mining and smelting industry.

First-line treatments for KRAS-mutant non-small cell lung cancer: current state and future perspectives.

mutations are common in non-small cell lung cancer (NSCLC) and are associated with patient prognosis; however, targeting has faced various difficulties. Currently, immunotherapy, chemotherapy, and chemoimmunotherapy play pivotal roles in the first-line treatment of -mutated NSCLC. Here, we summarize the current evidence on first-line therapies and compare the treatment outcomes and biomarkers for different regimens.

Concomitant ALK Fusion and TP53/EGFR Mutation Lead to Adverse Prognostic Outcome.

Lung cancer treatment has evolved at the molecular level. Detecting the presence of driver genes in lung cancer fundamentally alters the choice of therapeutic regimens and the outcome of this disease. ALK fusion mutation is one of the most important mutations in nonsmall cell lung cancer (NSCLC).

Differential Impacts of Invasive Percutaneous Coronary Intervention and Conservative Strategy on Elderly Patients with Non-ST-Segment Elevation Myocardial Infarction: An Analysis of Short-Term and Long-Term Survival.

The present study investigated the short-term and long-term outcomes of an invasive strategy in percutaneous coronary intervention (PCI) and a conservative strategy in non-ST-segment elevation myocardial infarction (NSTEMI) patients older than 80 years, with the aim to identify the strategy that is more beneficial than the other to this demographic population. A total of 139 patients from Beijing Anzhen Hospital and the Cao County People's Hospital were included in this study, comprising those aged >80 years and diagnosed with NSTEMI between 2017 and 2022. The main observation indicator was all-cause death, whereas the secondary indicators included composite endpoint events of recurrent myocardial infarction, need for urgent revascularization, recurrent angina, stroke, death, and major bleeding.

Ultrasonic-Assisted Extraction, Structural Characteristics, and Activity of Polysaccharides From Gymnocladus chinensis Baill.

In this study, the response surface method (RSM) was used to determine the optimal parameters of ultrasonic-assisted extraction of Gymnocladus chinensis Baill. polysaccharides (GCBPs). The optimal extraction conditions were as follows: a liquid-solid ratio of 50.

Exercise: a non-drug strategy of NK cell activation.

Natural killer (NK) cells are a critical component of the innate immune system and one of the immune cells most sensitive to exercise. So far, it is widely believed that moderate exercise can significantly enhance the proliferation and activity of NK cells, strengthening immune function. However, the impact of exercise on NK cells is a dynamic and complex process.

Safety, Efficacy, and Biomarker Analysis of Deulorlatinib (TGRX-326) in Anaplastic Lymphoma Kinase-Positive NSCLC: A Multicenter, Open-Label, Phase 1/1b Trial.

Introduction: Patients with anaplastic lymphoma kinase (ALK)-positive NSCLC developing resistance to second-generation inhibitors have limited treatment options. Deulorlatinib is a highly brain-penetrant, new-generation ALK/ROS1 inhibitor. We evaluated the safety, efficacy, and pharmacokinetics of deulorlatinib in ALK-positive NSCLC.

Delay Discounting and BMI in Hypertensives: Serial Mediations of Self-Efficacy, Physical Activity and Sedentary Behavior.

Objective: Our study aimed to examine the association between delay discounting (DD) and body mass index (BMI) in individuals with hypertension. Additionally, we sought to explore and compare the potential mediating effects of self-efficacy, physical activity and sedentary behavior in this association.

Methods: A cross-sectional survey was conducted in two cities in the Jiangsu province of China, specifically Nanjing and Yangzhou, from March to June 2023.

A bird's-eye view of research practices in mathematical cognition, learning, and instruction: Reimagining the status quo.

Research on mathematical cognition, learning, and instruction (MCLI) often takes cognition as its point of departure and considers instruction at a later point in the research cycle. In this article, we call for psychologists who study MCLI to reflect on the "status quo" of their research practices and to consider making instruction an earlier and more central aspect of their work. We encourage scholars of MCLI (a) to consider the needs of educators and schools when selecting research questions and developing interventions; (b) to compose research teams that are diverse in the personal, disciplinary, and occupational backgrounds of team members; (c) to make efforts to broaden participation in research and to conduct research in authentic settings; and (d) to communicate research in ways that are accessible to practitioners and to the general public.

How teachers make connections among ideas in mathematics instruction.

Conceptual understanding involves understanding connections among ideas within a domain. In this chapter, we consider how teachers support students in learning about connections among ideas in mathematics. We review research focusing on teachers' connection making in mathematics classrooms, and we consider several dimensions of variability in that connection making.

Melatonin partially rescues defects induced by tranexamic acid exposure during oocyte maturation in mice.

Tranexamic acid (TXA) is widely used among young women because of its ability to whiten skin and treat menorrhagia. Nevertheless, its potential effects on oocyte maturation and quality have not yet been clearly clarified. Melatonin (MT) is an endogenous hormone released by the pineal gland and believed to protect cells from oxidative stress injury.

Ecological investigations of giant Phaeocystis colonies in Viet Nam: I. Cell abundance and elemental composition.

Phaeocystis globosa is an important bloom-forming marine phytoplankton species that often accumulates to large levels in temperate and tropical waters and has significant impacts on food webs and biogeochemical cycles. It can form "giant" colonies that reach 3 cm in diameter. Microscopic observations, colony elemental composition, and pigment composition were analyzed to assess the characteristics of colonies as a function of colony size.

Telehealth With Comprehensive Live-Fed Real-World Data as a Patient Care Platform for Lung Cancer: Implementation and Evaluation Study.

Background: Telehealth has emerged as a popular channel for providing outpatient services in many countries. However, the majority of telehealth systems focus on operational functions and offer only a sectional patient journey at most. Experiences with incorporating longitudinal real-world medical record data into telehealth are valuable but have not been widely shared.