Publications by authors named "Rui Leng"
Objective: Interleukin-18 (IL-18) is a proinflammatory cytokine. This study aims to determine whether there is a causal relationship between circulating IL-18 concentrations and the risk of inflammatory and autoimmune diseases.
Methods: We collected significant single nucleotide polymorphisms (SNPs) associated with circulating IL-18 levels ( < 5 × 10) as instrumental variables (IVs) from a genome-wide association study (GWAS) involving 21,758 individuals of European descent.
Article Synopsis
- A study investigated the connection between a healthy lifestyle and the risk of developing rheumatoid arthritis (RA) by analyzing metabolic signatures in a large group of participants from the UK Biobank.
- The research focused on five healthy lifestyle factors: diet, exercise, smoking status, alcohol consumption, and body mass index, finding that a specific metabolic signature linked to these factors significantly reduced RA risk.
- The results suggested that the metabolic signature not only correlates strongly with healthy lifestyles but also mediates approximately 64% of the protective effects against RA, indicating both observational and genetic evidence for this relationship.
To assess the safety and efficacy of endovascular embolization techniques, we compared the short- to medium-term prognosis of coil embolization for symptomatic visceral aneurysms (SVAA) and asymptomatic visceral aneurysms (ASVAA) to identify risk factors associated with 30-day mortality. Explore the symptom profile and intrinsic associations of SVAA. A retrospective study of 66 consecutive patients at two tertiary care hospitals from 2010 to 2020 compared the short- to mid-term outcomes of 22 symptomatic VAAs and 44 asymptomatic VAAs treated with coil embolization.
View Article and Find Full Text PDFObjective: Previous observational studies demonstrated that a subset of patients with systemic lupus erythematosus (SLE) have markedly short telomere length in leukocytes. This study was undertaken to test whether leukocyte telomere length is causally associated with risk of SLE.
Methods: A 2-sample Mendelian randomization (MR) analysis was conducted to estimate causality of telomere length on SLE in European populations.
Purpose: To evaluate safety and efficacy of percutaneous mechanical thrombectomy using the Rotarex catheter combined with drug-coated balloon (DCB) in treatment of femoropopliteal artery occlusive disease.
Materials And Methods: Between January 2016 and February 2018, 81 patients with acute or subacute femoropopliteal artery occlusions were treated with the Rotarex catheter combined with DCB. Lesions were classified according to the onset of symptoms as acutely (< 14 d) or subacutely (14 d to 3 mo) occluded.
Recent evidence has demonstrated that UBASH3A gene was associated with multiple autoimmune diseases. The aim of this study was to explore the association between UBASH3A gene single-nucleotide polymorphisms (SNPs) and systemic lupus erythematosus (SLE) in a Chinese Han population. Four UBASH3A polymorphisms (rs11203203, rs3788013, rs2277798, and rs1893592) were genotyped using the Fluidigm 192.
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