The structure of meaning in schizophrenia: A study of spontaneous speech in Chinese.

Narrative speech production requires the retrieval of concepts to refer to entities, which need to be referenceable more than once for any form of narrative coherence to arise. Such coherence has long been observed to be affected in schizophrenia spectrum disorders (SSD), yet the underlying mechanisms have been a longstanding puzzle, with existing evidence predominantly derived from Indo-European languages. Here we analyzed two picture descriptions from 22 native Mandarin Chinese speakers with SSD and 15 healthy controls.

Discovery of an Efficacious RET PROTAC Degrader with Enhanced Antiproliferative Activity against Resistant Cancer Cells Harboring RET Solvent-Front Mutations.

Rearranged during transfection (RET) kinase is a validated therapeutic target for various cancers characterized by RET alterations. Although two selective RET inhibitors, selpercatinib and pralsetinib, have been approved by the FDA, acquired resistance through solvent-front mutations has been identified rapidly. Developing proteolysis targeting chimera (PROTAC) targeting RET mutations offers a promising strategy to combat drug resistance.

Niche and interspecific association of dominant zooplankton species near the Taishan coastal area in the South China Sea.

Marine zooplankton communities represent one of the most diverse and abundant species groups on earth. To investigate the ecological niche characteristics and interspecific interactions of marine zooplankton, and to elucidate their role in carbon deposition and biogeochemical cycling, we conducted a study on the zooplankton community near Taishan in the South China Sea between December 2015 and September 2016. Using niche breadth, niche overlap, the variance ratio method, chi-square tests, and linkage coefficients, we analyzed the interrelationships among the major zooplankton species.

Patient-reported outcome based symptom management is a better option for early postoperative recovery after breast cancer surgery: a parallel controlled randomized clinical trial.

Background: We aimed to assess the efficacy and feasibility of applying patient-reported outcome (PRO) based symptom management in the early postoperative period after breast cancer surgery.

Materials And Method: Before surgery, patients diagnosed with breast cancer who met the inclusion criteria were randomly assigned in a 1:1 ratio to receive either postoperative PRO-based symptom management or usual care. All patients completed the MD Anderson Symptom Inventory-Chinese version (MDASI-C) via the electronic PRO system preoperatively, on a daily basis postoperatively, and twice weekly after discharge, for a duration up to 2 weeks.

Phosphorylation-Dependent Dispersion of the Response Regulator in Bacterial Chemotaxis.

Protein phosphorylation is a fundamental cellular regulatory mechanism that governs the activation and deactivation of numerous proteins. In two-component signaling transduction pathways, the phosphorylation of response regulator proteins and their subsequent diffusion play pivotal roles in signal transmission. However, the impact of protein phosphorylation on their dispersion properties remains elusive.

Mechanosensitive dose response of the bacterial flagellar motor.

The bacterial flagellar motor is both chemo- and mechanosensitive. It is sensitive to the intracellular concentration of the chemotaxis response regulator CheY-P and to external load conditions. The motor's dose-response curve, which represents the probability of the motor rotating clockwise (CW bias) as a function of CheY-P concentration, characterizes its chemical sensitivity.

Prediction model establishment of prognosis factors for distant metastasis of hepatocellular carcinoma based on the SEER database.

Background: Distant metastasis in hepatocellular carcinoma (HCC) is an important indicator of poor patient prognosis. Identifying patients who are at high risk of metastasis early on is essential for creating personalized treatment plans, yet currently, there is a scarcity of effective predictive tools.

Objective: To investigate the effects of different factors on distant metastasis in HCC patients and to establish a clinical prediction model for predicting distant metastasis in HCC patients.

Multiepitope recognition technology promotes the in-depth analysis of antibody‒drug conjugates.

The dynamic tracking of antibody‒drug conjugates (ADCs) in serum is crucial. However, a versatile bioanalytical platform is lacking due to serious matrix interferences, the heterogeneity and complex biotransformation of ADCs, and the recognition deficiencies of traditional affinity technologies. To overcome this, a multiepitope recognition technology (MERT) was developed by simultaneously immobilizing CDR and non-CDR ligands onto MOF@AuNPs.

Molecular disturbances and thyroid gland dysfunction in rats chronically exposed to a high dose of NaAsO₂: Insights from proteomic and phosphoproteomic analyses.

Arsenic is a ubiquitous hazardous metalloid that poses a significant threat to human health. Although researchers have investigated the detrimental effects of arsenic on the thyroid, a comprehensive exploration of its toxicological impact and underlying molecular mechanisms remains to be conducted. Both this study and our previous reports demonstrated that chronic exposure to sodium arsenite (NaAsO) results in histological impairment and dysfunction of the thyroid glands in Sprague-Dawley (SD) rats.

Targeting the PDE3B-cAMP-autophagy axis prevents liver injury in long-term supercooling liver preservation.

In liver transplantation, donor livers are typically stored in a preservation solution at 4°C for up to 12 hours. However, this short preservation duration can lead to various issues, such as suboptimal donor-recipient matching and limited opportunities for organ sharing. Previous studies have developed a long-term preservation method called supercooling liver preservation (SLP) to address these issues.

Subcutaneous BNP Injections in Rabbits: A Novel Approach to Mitigate Myocardial Remodeling in Atrial Fibrillation.

Background: Atrial fibrillation (AF) is a prevalent cardiac arrhythmia associated with increased morbidity and mortality, highlighting the need for novel therapeutic strategies. This study aimed to evaluate the effects of B-type natriuretic peptide (BNP) on cardiac structural remodeling in a rabbit model of AF.

Methods: Rabbits were subjected to rapid pacing to induce an AF model, and BNP was delivered subcutaneously at a dose of 20 μg/kg/d twice per day for three weeks.

Exploring the Molecular Mechanisms of Resistance to Prochloraz by Isolated from Mango.

Mango stem-end rot caused by is a major postharvest disease in China. Prochloraz is commonly used for disease control in mango orchards and in storage. However, prochloraz resistance has been detected in .

Harnessing CuO-Doped 4--Butylpyridine in Spiro-OMeTAD: Study on Improved Performance and Longevity of Perovskite Solar Cells.

Recently, spiro-OMeTAD has gained prominence as a hole-transporting material (HTM) in high-performance perovskite solar cells (PSCs) due to its superior properties, cutting-edge HOMO state of energy, and solution processability. To promote hole mobility and conductivity, hygroscopic dopants and additives such as lithium bis(trifluoromethanesulfonyl)imide (Li-TFSI) and 4--butylpyridine (TBP) are typically incorporated. However, these components can lead to aggregation and hydrolysis in ambient conditions, forming pinholes and voids in the films.

Cancer immunogenic cell death via pyroptosis with CXCR4-targeted nanotoxins in hepatocellular carcinoma.

Introduction: Cytotoxic agents have shown limited benefits in hepatocellular carcinoma (HCC), mediated in part by the lack of targeting. As cell-penetrating peptides (CPPs) are capable of delivering various biologically active molecules into cells, including protein, peptides, small chemo-drugs, and nucleic acid with or without targeting, we developed T22-PE24, a CXCR4-targeted self-assembling cytotoxic nanotoxin, to effectively induce HCC pyroptosis.

Methods: T22 incorporating EGFP) or PE24 was purified from DE3 bacterial cells and characterized using transmission electron microscopy, the Zetasizer Nano, and SEC-HPLC.

Association between apolipoprotein E gene polymorphism and early MR findings in individuals with acute intracerebral hemorrhage: A retrospective cohort analysis.

Objective: The Apolipoprotein E (APOE) gene plays a significant role in the development and prognosis of intracerebral hemorrhage (ICH). Imaging features identified within 48 h of ICH onset, particularly on magnetic resonance imaging (MRI), are indicative of cerebral small vessel diseases (CSVD). Our study aimed to assess these imaging characteristics and investigate their association with the APOE gene among ICH patients.

Establishment and Clinical Significance of the Patient-Derived Xenograft Model of Colorectal Cancer.

Objectives: Patient-derived xenograft (PDX) models are widely acknowledged for their ability to reflect the heterogeneity of human cancers and can be used to improve preclinical models. In this study, we evaluated the factors affecting the tumor formation rate of the PDX colorectal cancer (CRC) model and conducted preliminary drug sensitivity tests.

Methods: CRC patients who underwent elective surgery at Shaoxing People's Hospital from November 2019 to October 2020 were included.

Amphiregulin promotes activated regulatory T cell-suppressive function via the AREG/EGFR pathway in laryngeal squamous cell carcinoma.

Background: Activated regulatory T cells (aTregs) play a vital role in promoting a tumor immunosuppressive microenvironment in laryngeal squamous cell carcinoma (LSCC). However, the regulatory factors that induce the generation of aTregs are not clear. Herein, we investigated the effect of amphiregulin (AREG) on the production of aTregs in the tumor microenvironment of LSCC.

Unveiling the impact of low-molecular-weight organic acids on enrofloxacin sorption in North China agricultural soil: Insights and implications.

Low-molecular-weight organic acids (LMWOAs) play a crucial role as components of dissolved organic matter in soil, influencing the sorption/desorption, degradation, and plant uptake of diverse pollutants within the agricultural soil ecosystem. This study delves into the sorption behavior and mechanism of the fluoroquinolone antibiotic enrofloxacin (ENR) on agricultural soil in North China, focusing on the impact of LMWOAs. Through batch equilibrium experiments, we explored the sorption/desorption kinetics of ENR under varying conditions such as temperature, pH, ion strength, and ion type, with the addition of acetic acid, oxalic acid, and citric acid individually.

Enhanced chemotaxis efficiency of in viscoelastic solutions.

Bacteria inhabit complex environments rich in macromolecular polymers that exhibit viscoelastic properties. While the influence of viscoelasticity on bacterial swimming is recognized, its impact on chemotaxis-a critical behavior for bacterial survival and colonization-remains elusive. In this study, we employed a microfluidic device to establish attractant gradients and observed the chemotactic behavior of in both viscoelastic solutions containing carboxymethyl cellulose (CMC) and Newtonian buffers.