Recyclable laccase nano-catalyst based on aldehyde-β-cyclodextrin and Fe-ZIF for diclofenac degradation.

Diclofenac (DCF), a commonly used non-steroidal anti-inflammatory pharmaceutical, causes harm to ecological environment safety. Thus, the degradation of DCF is of great value. Herein, we report a strategy to prepare a novel immobilised laccase (LAC), Fe-ZIF@β-CD-CHO-LAC, for DCF degradation.

IL-34/TREM2 modulates microglia-mediated inflammation and provides neuroprotection in a mouse model of sporadic Alzheimer's disease.

Background: As a recently identified cytokine, interleukin-34 (IL-34) is predominantly produced by neurons and functions as a modulator for glial functions. Emerging evidence indicates that IL-34 exerted neuroprotective effects in Alzheimer's disease (AD), but the underlying mechanism remained elusive.

Objective: To uncover the mechanisms by which IL-34 provides neuroprotection in AD.

Fast reverberation-reduction algorithm based on inexact matrix decomposition.

Traditionally, matrix-based methods for reverberation reduction have prioritized a high signal-to-reverberation ratio over low time consumption. This letter describes a fast reverberation-reduction algorithm. The reverberation-reduction problem is formulated as an inexact matrix decomposition.

Prevalence and molecular characterization of in endangered Eld's deer () in Hainan, China.

Introduction: is one of the most frequent microsporidia species causing digestive disorder mainly diarrhea in humans and animals. Eld's deer () is the class I national key protected wildlife and only distributed on Hainan Island in China. No report on the prevalence and molecular characterization of in wild Eld's deer worldwide.

Vitamin C-Dependent Intergenerational Inheritance of Enhanced Endurance Performance Following Maternal Exercise.

Declining levels of physical activity and fitness in children and youth are linked to negative health outcomes. This study investigates whether maternal exercise can enhance offspring's physical fitness. Our results demonstrate that maternal exercise improves offspring's endurance by changing muscle fiber composition and promoting mitochondrial biogenesis, with benefits lasting across generations.

Continuous-Wave Pumped Self-Assembled Colloidal Topological Lasers.

The field of optoelectronic integrated circuits is actively developing reliable and efficient room-temperature continuous-wave (CW) lasers. CW-pumped lasers combine the economical and simple manufacturing processes of colloidal semiconductor lasers with the efficient and stable output of continuous pumping, enabling them to significantly impact the field of semiconductor lasers. However, development is still severely challenged by limitations such as gain materials and cavity structures.

FTO/miR-503-5p/USP10 axis regulates neuronal endoplasmic reticulum stress-mediated apoptosis in ischemic stroke.

MiR-503-5p is reported to be implicated in ischemic diseases, including those affecting the heart and brain; however, its specific functions and upstream regulatory mechanisms in acute ischemic stroke (AIS) remain a mystery. To address this, we employed the middle cerebral artery occlusion/reperfusion (MCAO/R) and oxygen-glucose deprivation/reoxygenation (OGD/R) models to simulate ischemic/reperfusion conditions in vivo and in vitro. MiR-503-5p was found to exacerbate the brain infarct volume, neuronal damage and neurobehavioral impairment in the MCAO/R mice.

Performance of Hybrid Strategies Combining MDockPP and AlphaFold2 in CAPRI Rounds 47-55.

CAPRI challenges offer a range of blind tests for biomolecule interaction prediction. This study evaluates the performance of our prediction protocols for the human group Zou and the server group MDockPP in CAPRI rounds 47-55, highlighting the impact of AlphaFold2 (AF2) and the effectiveness of massive sampling approaches. Prior to AlphaFold2's release, our methods relied on homology modeling and docking-based protocols, achieving limited accuracy due to constraints in structural templates and inherent docking limitations.

Iron/manganese-zeolitic imidazolate framework (Fe/Mn-ZIF) nanozyme combined with acetylcholinesterase for colorimetric rapid detection of organophosphorus pesticides.

Organophosphorus pesticides (OPs) are extensively utilized in agricultural production, but they pose significant threats to environment and organisms. This study aims to develop a novel method for the rapid and efficient detection of OPs. Initially, an iron/manganese zeolitic imidazolate framework (Fe/Mn-ZIF) with excellent oxidase-like activity was synthesised.

Modulation of mitochondrial functions contributes to the protection of lamotrigine against Alzheimer's disease.

BackgroundOur previous studies have established that the broad-spectrum anti-epileptic drug lamotrigine (LTG) confers protection against cognitive impairments, synapse and nerve cell damage, as well as characteristic neuropathologies in APP/PS1 mice, a mouse model of Alzheimer's disease (AD). However, the precise molecular mechanisms responsible for this protective effect induced by LTG remain largely elusive.ObjectiveIn this study, we aimed to investigate the mechanisms underlying the beneficial effects of LTG against AD.

Unsupervised Ensemble Learning for Efficient Integration of Pre-trained Polygenic Risk Scores.

The growing availability of pre-trained polygenic risk score (PRS) models has enabled their integration into real-world applications, reducing the need for extensive data labeling, training, and calibration. However, selecting the most suitable PRS model for a specific target population remains challenging, due to issues such as limited transferability, data het-erogeneity, and the scarcity of observed phenotype in real-world settings. Ensemble learning offers a promising avenue to enhance the predictive accuracy of genetic risk assessments, but most existing methods often rely on observed phenotype data or additional genome-wide association studies (GWAS) from the target population to optimize ensemble weights, limiting their utility in real-time implementation.

Disentangled Active Learning on Graphs.

Active learning on graphs (ALG) has emerged as a compelling research field due to its capacity to address the challenge of label scarcity. Existing ALG methods incorporate diversity into their query strategies to maximize the gains from node sampling, improving robustness and reducing redundancy in graph learning. However, they often overlook the complex entanglement of latent factors inherent in graph-structured data.

Treadmill Exercise Mitigates Alzheimer's Pathology by Modulating Glial Polarization and Reducing Oligodendrocyte Precursor Cell Perivascular Clustering.

Purpose: This study aimed to investigate the pathological responses of glial cells at different distances from amyloid plaques and the characteristics of oligodendrocyte precursor cells (OPCs) in perivascular clustering. Additionally, it sought to explore the impact of exercise training on AD pathology, specifically focusing on the modulation of glial responses and the effects of OPC perivascular clustering.

Methods: Three-month-old C57BL/6 and APP/PS1 mice were divided into four groups: wild-type sedentary, wild-type exercise, sedentary AD, and exercise AD groups.

Remote photobiomodulation ameliorates behavioral and neuropathological outcomes in a rat model of repeated closed head injury.

Repeated closed-head injuries (rCHI) from activities like contact sports, falls, military combat, and traffic accidents pose a serious risk due to their cumulative impact on the brain. Often, rCHI is not diagnosed until symptoms of irreversible brain damage appear, highlighting the need for preventive measures. This study assessed the prophylactic efficacy of remote photobiomodulation (PBM) targeted at the lungs against rCHI-induced brain injury and associated behavioral deficits.

Depletion of myeloid-derived suppressor cells sensitizes murine multiple myeloma to PD-1 checkpoint inhibitors.

Background: Cancer immunotherapy using immune checkpoint blockade (ICB) has revolutionized cancer treatment. However, patients with multiple myeloma (MM) rarely respond to ICB. Accumulating evidence indicates that the complicated tumor microenvironment (TME) significantly impacts the efficacy of ICB therapy.

Mystery of gamma wave stimulation in brain disorders.

Neuronal oscillations refer to rhythmic and periodic fluctuations of electrical activity in the central nervous system that arise from the cellular properties of diverse neuronal populations and their interactions. Specifically, gamma oscillations play a crucial role in governing the connectivity between distinct brain regions, which are essential in perception, motor control, memory, and emotions. In this context, we recapitulate various current stimulation methods to induce gamma entrainment.

M1 Microglia-Derived Exosomes Promote A1 Astrocyte Activation and Aggravate Ischemic Injury via circSTRN3/miR-331-5p/MAVS/NF-κB Pathway.

Background: After ischemic stroke (IS), microglia and astrocytes undergo polarization, transforming into a pro-inflammatory phenotype (M1 or A1). According to previous studies, exosomes might play an important role in the interplay between M1 microglia and A1 astrocytes after IS.

Methods: We used the microglial oxygen-glucose deprivation/reperfusion (OGD/R) model and ultracentrifugation to extract M1 microglial exosomes (M1-exos).

AVE0991 ameliorates dopaminergic neuronal damage in Parkinson's disease through HOTAIRM1/miR-223-3p/α-synuclein axis.

Parkinson's disease (PD) is a prevalent type of neurodegenerative disorder. AVE0991, a non-peptide analogue of Ang-(1-7), by which the progression of PD has been discovered to be ameliorated, but the specific mechanism whereby AVE0991 modulates the progression of PD re-mains unclear. The mice overexpressing human α-syn (A53T) were established to simulate PD pathology, and we also constructed an in vitro model of mouse dopaminergic neurons overexpressing hα-syn (A53T).

Fat mass and obesity-associated protein alleviates cerebral ischemia/reperfusion injury by inhibiting ferroptosis via miR-320-3p/SLC7A11 axis.

Fat mass and obesity-associated protein (FTO) is a demethylase and has recently been found to have a protective effect in acute ischemic stroke (AIS), but the underlying mechanism is unclear to a large extent. New studies have found that the expression of certain miRNAs may be affected by N6-methyladenosine (m6A) levels. Here, using high-throughput sequencing and quantitative polymerase chain reaction, we found miR-320-3p was significantly up-regulated in AIS patients.

Trimethylamine N-Oxide Aggravates Neuro-Inflammation via lncRNA Fendrr/miR-145-5p/PXN Axis in Vascular Dementia Rats.

Purpose: Vascular dementia (VaD) is the second most common dementia in the world. An increasing number of studies have demonstrated the important role of long non-coding RNAs (lncRNAs) in VaD. Our previous investigation demonstrated that Trimethylamine-N-oxide (TMAO) exacerbates cognitive impairment and neuropathological alterations in VaD rats.