[Persistent Polyclonal B-Cell Lymphocytosis (PPBL): An Entity That Is Not What it Seems].

Persistent polyclonal B-cell lymphocytosis is a rare disease with chronic lymphocytosis of polyclonal origin, which is more frequent in mostly asymptomatic middle-aged female smokers. The hallmark of this entity is the presence of bilobed/binucleated B lymphocytes, which are polyclonal as demonstrated by immunophenotyping; an elevated IgM level is common. This disease shows, in most cases, an indolent course over many years and, although controversial, it may rarely convert to malignant lymphoma.

[Monitoring therapy with oral anticoagulants. Anticoagulation clinics vs assistant physician].

Most patients on chronic oral anticoagulant therapy are monitored through anticoagulation clinics, or rather by assistant physicians. Our aim was to compare warfarin anticoagulated patients who were treated with usual medical care (assistant physician) with those treated routinely at an anticoagulation clinic for anticoagulation control. The later was assessed by comparing in both groups of patients the proportion of INRs within the therapeutic range, above 5.