RGS2 is an innate immune checkpoint for suppressing Gαq-mediated IFNγ generation and lung injury.

Interferon gamma (IFNγ), a type II interferon, augments tissue inflammation following infections, leading to lethal acute lung injury (ALI), yet the mechanisms controlling IFNγ generation in the lungs remain elusive. Here, we identified regulator of G protein signaling 2 (RGS2) as a gatekeeper of the lung's IFNγ levels during infections. Deletion of RGS2 sustained an increase in IFNγ levels in macrophages, leading to unresolvable inflammatory lung injury.

Use of zinc sulfate for the development of zinc-fortified meat products from broiler meat.

Objective: The study aimed to assess the feasibility of incorporating food-grade zinc sulfate (ZnSO) for making zinc-fortified meatballs from broiler meat.

Materials And Methods: A total of 20 broiler breasts were treated with different concentrations of elemental zinc (Zn) of food-grade ZnSO₄ for making meatballs. The study included a control group without added Zn (T0: 0 mg/kg) and treatment groups with Zn concentrations of 10 mg/kg (T1), 20 mg/kg (T2), 30 mg/kg (T3), and 40 mg/kg (T4).

Porous and Amorphous MnMoS Chalcogel Electrode for High-Capacity Conversion-Based Lithium-Ion Batteries.

While Li-ion batteries (LIBs) are a leading energy storage technology, their energy densities are limited by the low capacity of conventional intercalation cathodes, driving interest in high energy-density Li-S batteries that make use of conversion chemistry. Achieving high capacity, reversibility, and cycle stability, and controlling volume changes in conversion batteries during the charge-discharge process, however, remains challenging. Here, we present a porous, amorphous, sulfide-based MnMoS chalcogel, which concurrently offers high capacity and cycle stability.

Thermal management challenges in lithium-ion batteries: understanding heat generation mechanisms.

This paper investigates heat generation in commercial 18 650 lithium-ion battery cells and the thermal management challenges from their high energy density and electrochemical processes. Thermal effects can degrade performance, accelerate aging, and increase thermal runaway risk. Using isothermal calorimetry and EIS, the study emphasizes optimizing thermal behavior to improve battery efficiency, safety, and durability.

Bioactivity of biogenic silver/silver chloride nanoparticles from rhizome extract: Antibacterial and antioxidant properties with anticancer potential against Ehrlich ascites carcinoma and human breast cancer cell lines.

Introduction: This study explores the synthesis and characterization of silver/silver chloride nanoparticles (Ag/AgCl-NPs) using rhizome extract and evaluates their bioactivities, including antibacterial, antioxidant, and anticancer potentials.

Methods: The synthesis of Ag/AgCl-NPs was initially confirmed by a color change and a sharp peak at 463 nm in UV-visible spectroscopy. Further characterization was conducted using scanning electron microscopy (SEM), X-ray powder diffraction (XRD), and fourier transform infrared spectroscopy (FTIR).

Transfer RNA acetylation regulates in vivo mammalian stress signaling.

Transfer RNA (tRNA) modifications are crucial for protein synthesis, but their position-specific physiological roles remain poorly understood. Here we investigate the impact of N4-acetylcytidine (acC), a highly conserved tRNA modification, using a Thumpd1 knockout mouse model. We find that loss of Thumpd1-dependent tRNA acetylation leads to reduced levels of tRNA, increased ribosome stalling, and activation of eIF2α phosphorylation.

Securing patient data in the healthcare industry: A blockchain-driven protocol with advanced encryption.

Background: Ensuring the security and privacy of patient data is a critical concern in the healthcare industry. The growing utilization of electronic data transmission and storage in medical records has amplified apprehensions about data security. However, due to varying stakeholder interests, not all data can be freely shared, necessitating the development of secure protocols.

Resf1 is a compound G4 quadruplex-associated tumor suppressor for triple negative breast cancer.

Patients with ER-negative breast cancer have the worst prognosis of all breast cancer subtypes, often experiencing rapid recurrence or progression to metastatic disease shortly after diagnosis. Given that metastasis is the primary cause of mortality in most solid tumors, understanding metastatic biology is crucial for effective intervention. Using a mouse systems genetics approach, we previously identified 12 genes associated with metastatic susceptibility.

Effects of a leave-on product on the strength of the dermoepidermal junction: An exploratory, intraindividual, randomized controlled trial in older adults with dry skin.

Background And Aims: Skin aging is associated with dry skin and a decrease of the strength of the dermoepidermal adhesion, which increases the risk for lacerations (skin tears). Application of leave-on products improves dry skin and seems to reduce skin tear incidence. The aim of this study was to measure the effects of a humectant containing leave-on product on the strength of the dermoepidermal junction in older adult participants with dry skin.

Unlocking stroke prediction: Harnessing projection-based statistical feature extraction with ML algorithms.

Non-communicable diseases, such as cardiovascular disease, cancer, chronic respiratory diseases, and diabetes, are responsible for approximately 71% of all deaths worldwide. Stroke, a cerebrovascular disorder, is one of the leading contributors to this burden among the top three causes of death. Early recognition of symptoms can encourage a balanced lifestyle and provide essential information for stroke prediction.

Amorphous K-Co-Mo-S Chalcogel: A Synergy of Surface Sorption and Ion-Exchange.

Chalcogel represents a unique class of meso- to macroporous nanomaterials that offer applications in energy and environmental pursuits. Here, the synthesis of an ion-exchangeable amorphous chalcogel using a nominal composition of KCoMoS (KCMS) at room temperature is reported. Synchrotron X-ray pair distribution function (PDF), X-ray absorption near-edge structure (XANES), and extended X-ray absorption fine structure (EXAFS) reveal a plausible local structure of KCMS gel consisting of Mo and Mo clusters in the vicinity of di/polysulfides which are covalently linked by Co ions.

Loss of NAT10 disrupts enhancer organization via p300 mislocalization and suppresses transcription of genes necessary for metastasis progression.

Acetylation of protein and RNA represent a critical event for development and cancer progression. NAT10 is the only known RNA acetylase that catalyzes the N4-actylcytidine (ac4C) modification of RNAs. Here, we show that the loss of NAT10 significantly decreases lung metastasis in allograft and genetically engineered mouse models of breast cancer.

Measuring the impact of responsible factors on CO emission using generalized additive model (GAM).

The indicators of economic and sustainable development ultimately significantly depend on carbon dioxide (CO) emissions in every country. In Bangladesh, there is an increasing trend in population, industrialization, as well as electricity demand generated from different sources, ultimately increasing CO emissions. This study explores the relationship between CO emissions and other significant relevant indicators.

Skin care types, frequencies and products: A cross-sectional study in German institutional long-term care.

Aim: The aim of the study was to describe types and frequencies of skin care interventions and products provided in institutional long-term care.

Materials And Methods: Baseline data from a cluster randomized controlled trial conducted in nursing homes in Berlin, Germany was collected before randomization. Numbers, proportions and frequencies of washing, showering and bathing, and the application of leave-on products were calculated.

The prevalence and severity of dry skin and related skin care in older adult residents in institutional long-term care: A cross-sectional study.

Objectives: To identify possible factors associated with different severities of xerosis cutis and to describe possible associations between (skin) care dependency and application of moisturizers.

Design: Cross-sectional study using baseline data from a cluster-randomized controlled trial. Demographic and health characteristics, skin physiological measurements, functional abilities and application of moisturizers were compared between the participants with mild and severe dry skin.