Systemic inflammation in relation to exceptional memory in the Long Life Family Study (LLFS).

Background And Objectives: We previously found a substantial familial aggregation of healthy aging phenotypes, including exceptional memory (EM) in long-lived persons. In the current study, we aim to assess whether long-lived families with EM and without EM (non-EM) differ in systemic inflammation status and trajectory.

Methods: The current study included 4333 participants of the multi-center Long Life Family Study (LLFS).

Risk of pancreatic cancer in individuals with celiac disease in the United States: A population-based matched cohort study.

Background: Celiac disease (CD) has been associated with gastrointestinal malignancies. However, the magnitude of the risk of pancreatic cancer (PC) associated with CD is much less clear, and risks have not been estimated from large populations.

Aim: To assess the risk of PC in CD patients.

Clinical characteristics and outcomes of COVID-19 in patients with autoimmune hepatitis: A population-based matched cohort study.

Background: Patients with autoimmune hepatitis (AIH) require life-long immunosuppressive agents that may increase the risk of poor coronavirus disease 2019 (COVID-19) outcomes. There is a paucity of large data at the population level to assess whether patients with AIH have an increased risk of severe diseases.

Aim: To evaluate the impact of pre-existing AIH on the clinical outcomes of patients with COVID-19.

Association between anti-inflammatory interleukin-10 and executive function in African American women at risk for Alzheimer's disease.

Introduction: African-Americans (AAs) are 64% more likely to be diagnosed with AD than non-Hispanic Whites. AAs with elevated AD biomarkers exhibit greater neurodegeneration in AD signature regions compared to non-Hispanic Whites with elevated AD biomarkers. This pilot trial examined whether normal or elevated plasma levels of interleukin (IL)-10 are associated with changes in executive function and short-term memory in AA women at risk for developing AD due to parental history.