Influence of Eu Doping on Physiochemical Properties and Neuroprotective Potential of Polyacrylic Acid Functionalized Cerium Oxide Nanoparticles.

Cerium oxide nanoparticles (CeONPs) exhibiting antioxidant properties are investigated as potential tools for neurodegenerative diseases. Here, we synthesized polyacrylic acid conjugated cerium oxide (CeO) nanoparticles, and further to enhance their neuroprotective effect, Eu was substituted at different concentrations (5, 10, 15 and 20 mol%) to the CeO, which can also impart fluorescence to the system. CeONPs and Eu-CeONPs in the size range of 15-30 nm were stable at room temperature.

Neuroprotective effects of polyacrylic acid (PAA) conjugated cerium oxide against hydrogen peroxide- and 6-OHDA-induced SH-SY5Y cell damage.

Cerium oxide nanoparticles have been widely investigated against neurodegenerative diseases due to their antioxidant properties that aid in quenching reactive oxygen species. In this study, polyacrylic acid conjugated cerium oxide (PAA-CeO) nanoparticles were synthesized in a 50-60 nm size range with a zeta potential of - 35 mV. X-ray photoelectron spectroscopy analysis revealed a mixed valence state of Ce and Ce.

Nanocarriers for effective nutraceutical delivery to the brain.

Neurodegenerative disorders are common among aging populations around the globe. Most are characterized by loss of neurons, protein aggregates, oxidative stress, mitochondrial damage, neuroinflammation among others. Although symptomatic treatment using conventional pharmacotherapy has been widely employed, their therapeutic success is limited due to varied reasons.

Unveiling the Effects of Rare-Earth Substitutions on the Structure, Mechanical, Optical, and Imaging Features of ZrO for Biomedical Applications.

The impact of selective rare-earth (RE) additions in ZrO-based ceramics on the resultant crystal structure, mechanical, morphological, optical, magnetic, and imaging contrast features for potential applications in biomedicine is explored. Six different RE, namely, Yb, Dy, Tb, Gd, Eu, and Nd alongside their variations in the dopant concentrations were selected to accomplish a wide range of combinations. The experimental observations affirmed the roles of size and dopant concentration in determining the crystalline phase behavior of ZrO.

Lanthanide phosphate (LnPO ) rods as bio-probes: A systematic investigation on structural, optical, magnetic, and biological characteristics.

The proposed work involves an exclusive study on the synthesis protocol, crystal structure analysis, and imaging contrast features of unique lanthanide phosphates (LnPO ). XRD and Raman spectra affirmed the ability of the proposed synthesis technique to achieve unique LnPO devoid of impurities. The crystal structure analysis confirms the P121/c1 space setting of NdPO , EuPO , GdPO , and TbPO that all uniformly crystallizes in monoclinic unit cell.

Design and structural investigations of Yb substituted β-Ca(PO) contrast agents for bimodal NIR luminescence and X-ray CT imaging.

The quest for the development of bone substitutes with contrast agents for diagnostic imaging subsists to distinguish synthetic bone from native human tissue. To this aim, ytterbium (Yb) substitutions in β-tricalcium phosphate (β-Ca(PO), β-TCP) as contrast agents has been developed to differentiate implant materials thereby, facilitating as host for bimodal imaging application by means of NIR luminescence and X-ray computed tomography techniques. A facile aqueous chemical precipitation route with the aid of surfactant is used for the synthesis of Yb substitutions in β-Ca(PO).

Cosubstitution of Lanthanides (Gd/Dy/Yb) in β-Ca(PO) for Upconversion Luminescence, CT/MRI Multimodal Imaging.

Multifunctional Gd, Dy and Yb cosubstitutions in β-Ca(PO) were achieved through a facile synthetic technique. Gd and Dy prefer to occupy the 7-fold coordinated Ca(1), 6- or 8-fold coordinated Ca(2), and 8-fold coordinated Ca(3) sites of the β-Ca(PO) structure. The shortest Ca(5)-O bond length of te Ca(5) site with 6-fold co-ordination favors Yb accommodation.

Substitutional limit of gadolinium in β-tricalcium phosphate and its magnetic resonance imaging characteristics.

To compensate the limitations of bone tissue magnetic resonance imaging (MRI), a series of gadolinium (Gd ) substituted β-Tricalcium phosphate [β-TCP, β-Ca (PO ) ] were developed. All the powders were characterized using XRD, Raman spectroscopy, Rietveld refinement of the XRD data and the studies confirmed the Gd occupancy at Ca (1), Ca (2) and Ca (3) lattice sites of β-Ca (PO ) HR-TEM analysis revealed the spherical nature of particles with diameter about 100 nm. The Gd doped β-Ca (PO ) exhibited non-toxic behaviour to MG-63 cells in vitro and the room temperature magnetic field versus magnetization measurements confirmed its paramagnetic behaviour.

Synthesis, structure, thermal stability, mechanical and antibacterial behaviour of lanthanum (La³⁺) substitutions in β-tricalciumphosphate.

Five different concentrations of lanthanum (La(3+)) substituted β-tricalcium phosphate [β-TCP, β-Ca3(PO4)2] were formed through aqueous precipitation technique and the results were compared with stoichiometric β-TCP. All the La(3+) substituted β-TCP powders were characterized using XRD, FT-IR, XRF, Raman spectroscopy and Rietveld refinement of the XRD data. The results from the investigation confirmed the presence of La(3+) in rhombohedral β-TCP structure.