Skin-resident memory T cells as a potential new therapeutic target in vitiligo and melanoma.

Tissue-resident memory T (T ) cells are abundant in the memory T cell pool and remain resident in peripheral tissues, such as the skin, where they act as alarm sensors or cytotoxic killers. T cells persist long after the pathogen is eliminated and can respond rapidly upon reinfection with the same antigen. When aberrantly activated, skin-located T cells have a profound role in various skin disorders, including vitiligo and melanoma.