Publications by authors named "Rufin M T Kouipou"
Article Synopsis
- - Propolis from Cameroon was studied, leading to the discovery of a new isoflavonol and other compounds, some of which had not been previously identified from propolis.
- - The compounds were tested for their effects on oxidative stress, with one (2-hydroxy-8-prenylbiochanin A) showing significant inhibition of nitric oxide production and others demonstrating higher reactive oxygen species inhibition than ibuprofen.
- - Cytotoxicity and antifungal activities were also assessed, revealing moderate cytotoxicity for some extracts and lower antifungal efficacy compared to standard treatments like fluconazole.
Article Synopsis
- The study investigates the potential of Terminalia mantaly and Terminalia superba, plants used in traditional medicine in Cameroon, as sources for new anti-malarial drugs, especially against artemisinin-resistant malaria parasites.
- Twelve extracts and fractions from these plants were tested for their effectiveness against both chloroquine-resistant and sensitive strains of Plasmodium falciparum using specific assays in a lab setting.
- Results showed that most extracts had potent antiplasmodial activities, with two extracts showing particularly high efficacy and selectivity, making them promising candidates for further drug development.
Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against Some Pathogenic Yeasts and Enzymes of Metabolic Significance.
Marthe Aimée Tchuente Tchuenmogne Thierry Ngouana Kammalac Sebastian Gohlke Rufin Marie Toghueo Kouipou Abdulselam Aslan
Medicines (Basel)
January 2017
: Pathogenic yeasts resistance to current drugs emphasizes the need for new, safe, and cost-effective drugs. Also, new inhibitors are needed to control the effects of enzymes that are implicated in metabolic dysfunctions such as cancer, obesity, and epilepsy. The anti-yeast extract from (Combretaceae) was fractionated and the structures of the isolated compounds established by means of spectroscopic analysis and comparison with literature data.
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