Publications by authors named "Rufaida Mazahir"
Effectiveness of the primary Bacillus Calmette-Guérin vaccine against the risk of Mycobacterium tuberculosis infection and tuberculosis disease: a meta-analysis of individual participant data.
Lancet Microbe
February 2025
Background: Tuberculosis vaccine trials using disease as the primary endpoint are large, time consuming, and expensive. An earlier immunological measure of the protection against disease would accelerate tuberculosis vaccine development. We aimed to assess whether the effectiveness of the Bacillus Calmette-Guérin (BCG) vaccine for prevention of Mycobacterium tuberculosis infection was consistent with that for prevention of tuberculosis disease.
View Article and Find Full Text PDFTo determine whether or not Darbepoetin alpha (DA) was non-inferior to recombinant human erythropoietin (rHuEPO) in the treatment of anemia in children with chronic kidney disease (CKD) stage 3-5 (on or not on dialysis). This was a randomized, open-label, two-arm, parallel group, active-controlled, non-inferiority trial conducted at a tertiary care center in New Delhi, India. Fifty patients of either gender (aged 1-18 years) with CKD stage 3-5 (on or not on dialysis) who had baseline hemoglobin (Hb) between 9 and 12 g/dL and were on stable erythropoietin therapy for at least 8 weeks were randomized (1:1) to either continue rHuEPO or switch to DA therapy for a period of 28 weeks.
View Article and Find Full Text PDFArticle Synopsis
- Idiopathic nephrotic syndrome (INS) is the most common kidney disorder in children globally, but there's limited research on its impact on quality of life (QOL), especially in developing countries.
- A study in India compared the QOL of 102 children with INS to healthy controls using PedsQL™4.0 scales, finding significant lower scores in physical, social, and school domains for those with INS.
- Key factors affecting QOL included older age, higher relapses, and more immunosuppressant use, with the greatest impact on school functioning, particularly among children with steroid-resistant INS.
Therapeutic Plasma Exchange in Children - Experience From a Tertiary Care Center.
Indian Pediatr
December 2021
Objective: To assess the safety, efficacy and outcomes of therapeutic plasma exchange (TPE) in children.
Methods: Data were retrieved from hospital records for all children £18 years who underwent TPE between August, 2011 and July, 2018.
Results: 46 children [median (range) age 96 (8-204) months] underwent 293 sessions of TPE by membrane plasma separation technique.
Objective: The objective of the current study was to evaluate the timing of first extubation and compare the outcome of patient extubated early with others; we also evaluated the predictors of early extubation in our cohort.
Materials And Methods: This prospective cohort study included children <1 year of age undergoing surgery for congenital heart disease. Timing of first extubation was noted, and patients were dichotomized in the group taking 6 h after completion of surgery as cutoff for early extubation.
Vasoactive-ventilation-renal score in predicting outcome postcardiac surgery in children.
Int J Crit Illn Inj Sci
January 2018
Objective: The objective of this study was to evaluate vasoactive-ventilation-renal (VVR) score to predict outcome postcardiac surgery in children and establish the time at which the score is best to predict outcome.
Materials And Methods: This prospective cohort included children ≤18 years recovering from cardiac surgery for congenital heart disease. Data were collected from the Intensive Care Unit (ICU) and vasoactive-inotropic score (VIS) and VVR scores calculated at admission, 24 h, and 48 h postoperatively.