Combined Charlson comorbidity/C-Reactive Protein Index Is a Novel Predictor in Renal Cell Carcinoma: Analysis of the International Marker Consortium for Renal Cancer (INMARC) Registry.

Objective: To evaluate predictive ability of a novel combined index, Charlson comorbidity index and C-reactive protein (CCI-CRP), for outcomes in renal cell carcinoma (RCC), and compare predictive outcomes with of CCI-CRP to its separate components and to the UCLA integrated staging system (UISS).

Patients And Methods: We retrospectively analyzed INMARC registry of RCC patients. Receiver Operator Characteristics (ROC) analysis was fitted to identify threshold defining low-CRP (LCRP) and high-CRP (HCRP).

Characterization of Expression in Renal Cell Carcinoma.

Purpose: Given the emergence of PSMA-targeted diagnostic agents and therapeutics, we sought to investigate patterns of expression in RCC and their impacts on RCC outcomes.

Methods: We conducted a pooled multi-institutional analysis of patients with RCC having undergone DNA and RNA next-generation sequencing. -high/low expression was defined as the ≥75th/<25th percentile of RNA transcripts per million (TPM).

Few-cycle optical vortices for strong-field physics.

We report on the generation of optical vortices with few-cycle pulse durations, 500μJ per pulse, at a repetition rate of 1 kHz. To do so, a 25 fs laser beam at 800 nm is shaped with a helical phase and coupled into a hollow-core fiber filled with argon gas, in which it undergoes self-phase modulation. Then, 5.

Photon Pathways and the Nonperturbative Scaling Law of High Harmonic Generation.

High harmonic generation (HHG) has become a core pillar of attosecond science. Traditionally described with field-based models, HHG can also be viewed in a parametric picture, which predicts all properties of the emitted photons, but not the nonperturbative efficiency of the process. Driving HHG with two noncollinear beams and deriving analytically the corresponding yield scaling laws for any intensity ratio, we herein reconcile the two interpretations, introducing a generalized photonic description of HHG.

On-treatment risk model for predicting treatment response in advanced renal cell carcinoma.

Purpose: The field of immunotherapy combinations for advanced renal cell carcinoma (aRCC) has been expanded in recent years. However, the treatment response varies widely among individual patients. It is still a challenge to predict oncological outcome in clinical practice.

Innovative and sustainable cultivation strategy for the production of Spirulina platensis using anaerobic digestates diluted with residual geothermal water.

The following study investigates the possibility of growing the Spirulina platensis (S. platensis) cyanobacteria on two agro-industrial anaerobic digestion (AD) digestates diluted with geothermal water. The two digestates (FAWD: Food and Agricultural Wastes Digestate and CDD: Cheese Diary Digestate) were selected based on their different chemical characteristics, attributed to the type of feedstock and the operating conditions used during the AD process.

Nonlinear up-conversion of a polarization Möbius strip with half-integer optical angular momentum.

Symmetries and conservation laws of energy, linear momentum, and angular momentum play a central role in nonlinear optics. Recently, paraxial light fields with nontrivial topology have been attracting a keen interest. Despite not being eigenstates of the orbital and spin angular momenta (OAM and SAM), they are eigenstates of the generalized angular momentum (GAM) operator-a mixture of the OAM and SAM operators with fractional eigenvalues.

Current Soccer Footwear, Its Role in Injuries and Potential for Improvement.

Soccer is the most popular sport in the world and generates great financial revenue. It is also a sport whose practice has evolved considerably in terms of intensity and commitment, and in which the intrinsic risk of injury (not directly related to an interaction with the environment) is particularly high. In this context, the cleated shoe as a major component of soccer equipment may play a key role in the overexposure to injury.

Timescales of water accumulation in magmas and implications for short warning times of explosive eruptions.

Water plays a key role in magma genesis, differentiation, ascent and, finally, eruption. Despite the recognized crucial function of water, there are still several issues that continue to blur our view about its role in magmatic systems. What are the timescales of HO accumulation in crystallizing magmas? What are the ascent rates of water-rich residual melts leading to explosive eruptions? Here, we track the timescale of water accumulation in a residual melt resulting from crystallization of a hydrous CO-bearing magmatic mass stored at mid- to deep-crustal levels in a subduction-related geodynamic setting.

Does Intensive Soccer Playing During the Growth Period Lead to Leg Length Discrepancies?

Leg length discrepancies (LLD) are a common reason for podiatry consultations and can affect up to 90% of the overall population. Furthermore, it is widely recognized that intensive participation in certain sports can alter bone development. The aim of this study is to explore any possible relation between playing soccer and the appearance or evolution of LLD, by means of a retrospective study based on the analysis of case reports of patients followed for foot or plantar troubles.

Efficacy of prophylactic and early fluconazole treatment on systemic candidiasis in experimentally neutropenic rabbits.

The efficacy of prophylactic and early fluconazole treatment on experimental systemic candidiasis was investigated in neuropenic rabbits. Fifteen rabbits were used and divided into three groups: fluconazole was started 24 h before the inoculation of Candida albicans in the first group, and 24 h after the inoculation in the second group. The third group was the control group without antifungal therapy.

[The acquisition in dogs of temporal regulation by differentiated reinforcement of the response duration using an exteroceptive component and the pharmacological modulation of this reflex (diazepam, clozapine)].

Transformation of expectation phenomenon into the phenomenon of temporal regulation is usually achieved by the suppression of preliminary factors or by means of their physical modification. Our studies show that such transformation can be obtained in dogs using Kupalov paradigm with the presentation of additional stimuli. These stimuli strictly identical, from the physical point of view, to the signals which interrupt expectation are randomly introduced into the temporal limit.