Synthetic approaches for novel fused pyrimidine derivatives: Design, structural characterization, antiviral, antitumor, and molecular docking evaluation.

The goal of this work was to synthesize new compounds for anticancer evaluation as a trial to obtain new antitumor agents with higher activity and fewer side effects. Therefore, the precursor 2,2'-(1,4-phenylenebis (thiazole-4,2-diyl))bis (3-(dimethylamino)acrylonitrile) was used to synthesize various azolopyrimidine derivatives connected to the thiazole moiety. Compounds -, including pyrazolopyrimidine, triazolopyrimidine, and others, were produced by reacting enaminonitrile with different -nucleophiles.

High early strength concrete incorporating waste derived nanomaterials for sustainable construction.

This paper contributes to the expanding knowledge base on nanomaterial-enhanced cementitious composites, offering valuable insights for developing high-performance, sustainable concrete solutions. The study assessed the effects of three different types of nanomaterials-nano clay (NC), nano silica (NS), and nano cellulose (NCel)-on the compressive strength of high-early-strength concrete (HESC) through both experimental studies and a 2 factorial design. Incorporating nanomaterials into the HESC matrix led to a decrease in workability, with NCel demonstrating the least impact on this property across all studied replacement percentages.

Advance drought prediction through rainfall forecasting with hybrid deep learning model.

Drought is a natural disaster that can affect a larger area over time. Damage caused by the drought can only be reduced through its accurate prediction. In this context, we proposed a hybrid stacked model for rainfall prediction, which is crucial for effective drought forecasting and management.

Asparagine availability controls germinal center B cell homeostasis.

The rapid proliferation of germinal center (GC) B cells requires metabolic reprogramming to meet energy demands, yet these metabolic processes are poorly understood. By integrating metabolomic and transcriptomic profiling of GC B cells, we identified that asparagine (Asn) metabolism was highly up-regulated and essential for B cell function. Asparagine synthetase (ASNS) was up-regulated after B cell activation through the integrated stress response sensor GCN2.

Ultrafast structural dynamics of UV photoexcited ,-1,3-cyclooctadiene observed with time-resolved electron diffraction.

Conjugated diene molecules are highly reactive upon photoexcitation and can relax through multiple reaction channels that depend on the position of the double bonds and the degree of molecular rigidity. Understanding the photoinduced dynamics of these molecules is crucial for establishing general rules governing the relaxation and product formation. Here, we investigate the femtosecond time-resolved photoinduced excited-state structural dynamics of ,-1,3-cyclooctadiene, a large-flexible cyclic conjugated diene molecule, upon excitation with 200 nm using mega-electron-volt ultrafast electron diffraction and trajectory surface hopping dynamics simulations.

A sustainable approach using natural phosphates impregnated with nickel hydroxide nanoparticles: a cost-effective solution for alcohol oxidation'.

This study introduces a novel and effective approach for the electrocatalytic oxidation of alcohols, showcasing the development of a highly active and cost-effective anode catalyst for methanol and ethanol. A dual-embedded Ni electrode, named (Ni@NATPhos/Ni), is based on a carbon paste electrode modified with natural phosphate impregnated with nickel ions. A layer of nickel nanoparticles was then added electrochemical deposition, using a precise combination of wet impregnation and potentiostatic electrodeposition techniques.

Daily river flow simulation using ensemble disjoint aggregating M5-Prime model.

Accurate prediction of daily river flow ( ) remains a challenging yet essential task in hydrological modeling, particularly crucial for flood mitigation and water resource management. This study introduces an advanced M5 Prime (M5P) predictive model designed to estimate as well as one- and two-day-ahead river flow forecasts (i.e.

A systematic review of the potential treatment effects of topical epidermal growth factor for ocular surface disorders.

Purpose: This systematic review, evaluated the role of epidermal growth factor (EGF) in corneal wound healing and the pathogenesis of ocular surface disorders (OSDs).

Methods: The clinical and experimental application of topical EGF therapy for OSDs was reviewed. This systematic research assessed articles published on PubMed/MEDLINE from 2000 to 2023 and summarized and discussed the findings of 38 experimental and 10 clinical studies.

Enhancing Epilepsy Seizure Detection Through Advanced EEG Preprocessing Techniques and Peak-to-Peak Amplitude Fluctuation Analysis.

Naturally, there are several challenges, such as muscular artifacts, ocular movements and electrical interferences that depend on precise diagnosis and classification, which hamper exact epileptic seizure detection. This study has been conducted to improve seizure detection accuracy in epilepsy patients using an advanced preprocessing technique that could remove such noxious artifacts. In the frame of this paper, the core tool in the area of epilepsy, EEG, will be applied to record and analyze the electrical patterns of the brain.

How Physician-Insurance Contracting Contributes to the Medical Exodus and Access to Ophthalmic Care in Puerto Rico.

Background: Puerto Rico (PR) has experienced significant demographic changes, characterized primarily by an aging population and an unprecedented exodus of medical doctors. Ophthalmologists are of particular concern as they commonly serve older populations, and the island has high rates of some age-related eye diseases in the United States (US). Our research aims to investigate the factors driving ophthalmologists in PR to emigrate to the mainland US.

Organelle-level toxicity of nanometals relevant to titanium implants. Original research and comprehensive literature overview.

Objective: This study analyzed organelle toxicities of nanometals applied as free formulations or titanium rod-coating materials in rats.

Methods: All materials were injected intraperitoneally, including the physiological saline applied to the control group. The first experimental group was implanted with nanosilver-coated titanium rods, and the second, third, and fourth groups received free nanosilver at rising levels.

Echocardiographic Evaluation of Chronic Aortic Regurgitation: Comparison With Cardiac Magnetic Resonance and Implications for Guideline Recommendations.

Background: Guidelines for echocardiographic evaluation of aortic regurgitation (AR) have not been validated against an independent quantitative standard.

Objectives: The aim of this study was to evaluate the accuracy of the ASE (American Society of Echocardiography) AR guidelines against cardiac magnetic resonance (CMR) and to develop simplified approaches for detection of significant AR.

Methods: Patients with AR underwent echocardiography and CMR <4 hours apart.

Isolated hydatid cyst in the medial rectus muscle: unveiling a rare orbital occurrence.

Background: Orbital hydatid disease, while rare, should be included in the differential diagnosis of unilateral proptosis, particularly in endemic areas. Accurate diagnosis and comprehensive management are essential for effective treatment and favorable long-term outcomes.

Case Presentation: A 12-year-old boy presented with a one-month history of diplopia and left-sided proptosis.

Recent Developments in the Adsorption of Heavy Metal Ions from Aqueous Solutions Using Various Nanomaterials.

Water pollution is caused by heavy metals, minerals, and dyes. It has become a global environmental problem. There are numerous methods for removing different types of pollutants from wastewater.

Outcomes and prognostic factors in pediatric orbital trapdoor fracture: a multi-center study.

Purpose: To evaluate clinical presentations, computed tomography (CT) findings, and various prognostic factors affecting the surgical outcomes of trapdoor fractures.

Methods: This retrospective multi-center study reviewed medical records and orbital CT scans of patients under 21 years old, diagnosed with isolated trapdoor fractures. The study was conducted across multiple medical centers, including emergency and clinical departments in Isfahan, Shiraz, and Tehran-Iran.

Treatment of aggressive posterior retinopathy of prematurity accompanied by nasolacrimal duct obstruction with purulent discharge: A case report.

This case demonstrates that probing and 10% povidone-iodine irrigation of the nasolacrimal duct prior to intravitreal bevacizumab injection can safely reduce the risk of endophthalmitis in infants with aggressive posterior retinopathy of prematurity and nasolacrimal duct obstruction. This method provides a viable treatment alternative when laser therapy alone is insufficient.

Pediatric Kidney Donation and Transplantation in Kingdom of Saudi Arabia.

The evolution of pediatric kidney donation and transplantation in the Kingdom of Saudi Arabia underscores the transformative effects of strategic initiatives and institutional reforms aimed at fostering self-sufficiency and ethical stewardship in transplantation. The ascendance of the Saudi Center for Organ Transplantation as a regional hub for organ procurement and transplantation is a testament to Saudi Arabia's commitment to advancing health care delivery and promoting international collaboration in combating organ trafficking and commercialism. Moving forward, sustained investments in infrastructure, capacity building, and regulatory oversight will be paramount to addressing emerging challenges and consolidating Saudi Arabia's position as a global leader in transplantation.

Pollen and Leaf Micromorphological Characteristics of Spiny Almonds (Prunus subgenus Amygdalus) in Iran.

This study investigates the micromorphological characteristics of pollen grains and leaf epidermal cells from 20 accessions across four species of spiny almonds using scanning electron microscopy. Thirteen quantitative traits of pollen grains, including exine sculpturing, were analyzed alongside qualitative features such as shape, exine sculpture type, and aperture type. Additionally, four quantitative and five qualitative features of the leaf epidermis were examined, focusing on cuticular ornamentation patterns, types of epicuticular wax, and stomatal measurements.

Effectiveness of FIFA 11+ Injury Prevention Programs in Reducing Head and Neck Injuries, Including Concussion, Among Soccer Players: A Systematic Review and Meta-Analysis.

Unlabelled: The Federation Internationale de Football Association (FIFA) 11+ and 11+ Kids injury prevention programs have shown success in reducing overall injury risk in soccer players, yet their specific impact on head and neck injuries remains inadequately explored.

Purpose: To evaluate the effectiveness of FIFA 11+ and 11+ Kids injury prevention programs in reducing the incidence of head and neck injuries among soccer players.

Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, 2 investigators independently conducted searches in databases (Cochrane Library, PubMed, Web of Science, and PEDro) using keywords like "FIFA 11+," "football," "soccer," and "injury prevention.

Exploring the Potential of Electronic Patient-Generated Health Data for Evaluating Treatment Response to Intramuscular Steroids in Rheumatoid Arthritis: Case Series.

Background: Mobile health devices are increasingly available, presenting exciting opportunities to remotely collect high-frequency, electronic patient-generated health data (ePGHD). This novel data type may provide detailed insights into disease activity outside usual clinical settings. Assessing treatment responses, which can be hampered by the infrequency of appointments and recall bias, is a promising, novel application of ePGHD.

Factors Associated with Axial Spondyloarthritis Remission in a Cohort of Saudi Patients with Longstanding Disease: A Multicenter Prospective Cohort Study.

Background/aim: Earlier treatment in axial spondyloarthritis (axSpA) was proposed to alter disease prognosis in this often-challenging condition. We aimed to assess the proportion of patients and prognostic factors associated with axSpA remission.

Objective: The aim was to determine the number of patients with Ankylosing Spondylitis Disease Activity Score with C-reactive protein (ASDAS-CRP) of <2.