Publications by authors named "Ruei-Huei Chen"
Design, synthesis and evaluation of telomerase inhibitory, hTERT repressing, and anti-proliferation activities of symmetrical 1,8-disubstituted amidoanthraquinones.
Chia-Chung Lee Kuo-Feng Huang Deh-Ming Chang Jung-Jung Hsu Fong-Chun Huang Chun-Liang Chen Tsung-Chih Chen Ruei-Huei Chen
Eur J Med Chem
April 2012
Article Synopsis
- A series of disubstituted 1,8-diamidoanthraquinones were created and tested for their ability to inhibit cell growth, telomerase activity, and hTERT expression.
- All compounds except 3a and 3s were chosen for further study by the NCI screening system.
- Notably, compounds 4e and 4k showed an ability to inhibit telomerase activity, suggesting that their effects on cell toxicity and telomerase inhibition could help in developing strategies that target telomerase.
A series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,11-dione tetracyclic analogues with different side chain were prepared using an various synthetic route via acylation, cyclization, condensation, and intramolecular heterocyclization. Tetracyclic system containing alkyl and aryl, aromatic and heterocyclic, linear and cyclic, polar and apolar, and basic and acids residues were incorporated. They were evaluated for their effects on telomerase activity, hTERT expression, cell proliferations, and in vitro cytotoxicity against NCI's 60 cell line human tumor screen.
View Article and Find Full Text PDF