Single-cell deconvolution reveals high lineage- and location-dependent heterogeneity in mesenchymal multivisceral stage 4 colorectal cancer.

Metastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major cause of death in Union for International Cancer Control (UICC) stage IV CRC patients. Insights into differential site-specific reconstitution of tumor cells and the corresponding tumor microenvironment are still missing.

Partial link between the seasonal acquisition of cold-tolerance and desiccation resistance in the goldenrod gall fly Eurosta solidaginis (Diptera: Tephritidae).

Possible links between seasonal increases in cold-tolerance and desiccation resistance were examined in field-collected larvae of the goldenrod gall fly, Eurosta solidaginis. From 20 September to 30 October 2001, larvae exhibited a gradual increase in cold-tolerance culminating in 100% survival of freezing at -20 degrees C for 24 h. The increase in cold-tolerance was probably due to a concomitant increase in cryoprotectants as measured by hemolymph osmolality (488-695 mOsmol kg(-1)).