[Comparative study of the chemotherapeutic effectiveness of mecillinam, ampicillin and their combination in coli bacillary pyelonephritis in rats].

The chemotherapeutic effect of mecillinam and ampicillin was studied comparatively on rats with hematogenic obturation colibacillary pyelonephritis. The antibiotics were administered intragastrically in a dose of 100 mg/kg for 7 days. The treatment was started 24 hours after infection.

[The effect of nitrofurans on the membrane apparatus of coccal bacteria].

Secondary membrane effects on the membrane apparatus of coccus bacteria were being studied. Cultivation of Micrococcus lysodeikticus and Staphylococcus aureus cells on subbacteriostatic concentrations of nitrofurans results in a lower biosynthesis of many membrane proteins, as well as in inhibiting the activity of respiratory enzymes, i. e.

[Mechanisms of the inhibitory effect of clonidine on the reproductive system of female rats].

It has been demonstrated in experiments on puberal and infantile female rats that a single subcutaneous injection of clonidine (0.03 mg/kg) disturbed whereas in a dose of 1 mg/kg completely inhibited spontaneous or induced ovulation as well as sexual receptivity. When injected in a daily dose of 0.

[Cytogenetic characteristics of 5 experimental mammalian pathology models].

A cytogenetic study of bone marrow cells was carried out first under conditions of toxic hepatopathy, experimental toxic nephropathy, alloxan diabetes in rats and under conditions of colibacillar and pyocyanic sepsis in mice in different periods of pathology. These experimental models may be used in research on medicinal mutagenesis.

[Chemotherapeutic effectiveness of gentamycin, tobramycin and sisomycin in Pseudomonas aeruginosa pyelonephritis in rats compared with dioxidine].

The chemotherapeutic efficacy of gentamicin, tobramycin, sisomicin and dioxydin was studied and compared in rats with hematogenic obturation P. aeruginosa pyelonephritis. The drugs were injected intramuscularly in doses of 5, 8, 8 and 50 mg/kg, respectively for 7 days a day after infection.

[Characteristics of the distribution of long-acting sulfanilamides in purulent pyelonephritis in rats].

Distribution of sulfalen, sulfadimethoxine and sulfamethoxypyridazine in the blood and organs of rats and binding of the drugs to the blood serum proteins of the animals with experimental P. aeruginosa pyelonephritis were studied. It was shown that in rats with P.

[Action of dioxidine on the membrane apparatus of the bacterial cell].

A study of dioxydine effect on the membrane apparatus of Staphylococcus aureus 209 P and Micrococcus lysodeikticus revealed a decrease in the dehydrogenase activity of membrane preparations and in the specific concentration of cytochromes, if cells had been cultivated in a medium with subbacteriostatic concentrations of dioxydine. The total activity of the respiratory chain was slightly decreased. Conservatism of the membrane apparatus of the bacteria studied was demonstrated.

[Dioxidine and carbenicillin in Pseudomonas aeruginosa pyelonephritis in rats].

Dioxidine (50 mg/kg a day) and carbenicillin (500 mg/kg a day) administered to rats with Ps. aeruginosa hematogenic pyelonephritis for 7 days brought about high therapeutic effect accompanied by bacteremia elimination, noticeable reduction of bacteriuria and dissemination of renal tissue, by improvement of the histological structure of the kidneys as compared with untreated animals. Complete recovery of all the animals (sterilization of the urine and tissue of both the kidneys), and abolition of pyelonephritis signs in the histological structure of the kidneys are attained as a result of combined use of dioxidine and carbenicillin in doses 25 and 250 mg/kg, respectively.

[Comparison of the antimicrobial properties of catamin AB and rockal and their action on bacterial membrane systems].

The antimicrobial properties of two cationic detergents, i.e. rockal, an antiseptic made in England and catamine AB, its analog made in the USSR were compared.

[Pharmacokinetic interference between furosemide and cephalosporins].

The effect of furosemid was studied on rats in comparison to that of etamid with respect to circulation in the body of some cephalosporins, such as cephalotin, cephaloridin, cephazolin, cephacetrile, cephapirin, cefradin and cefalexin. Furosemid and etamid were administered to the rats intraperitoneally in a dose of 100 mg/kg 30 minutes before exposure to the cephalosporins. Cefalexin was administered intragastrically in a dose of 100 mg/kg and the other cephalosporins were administered intramuscularly in a dose of 20 mg/kg.

[Cephalosporin pharmacokinetics in rabbits].

The kinetics of the blood serum and urine levels of cephalotin, cephaloridine, cephazolin, cephacetrile, cephapirin, cefalexin and cefradin was studied on rabbits treated with the antibiotics administered intravenously. The pharmacokinetic constants of the cephalosporins were calculated on the basis of the one-compartmental mathematical model. It was shown that cephalotin and cephapirin had the highest blood elimination rates.

[Sulfalene circulation in kidney disease patients].

Examinations of patients suffering from chronic nephritis with the nephrotoxic syndrome and amyloidosis of the kidneys with unchanged glomerular filtration showed that the rate of sulfalen excretion in the patients with the kidney diseases was higher than that in the persons of the control group. The sulfalen elimination rate and the plasmatic clearance in such patients were higher. The higher rate of sulfalen elimination was due to increased excretion of the unchanged drug with urine.

[Bacteriological and pathomorphological control of the effectiveness of the therapy of experimental pyocyanic burn infection].

Bacteriological and pathomorphological characteristics of experimental pyocyanic burn infection in noninbred albino mice are presented. The model was used for comparative investigation of the chemotherapeutic efficacy of quinoxidin, dioxidin, carbenicillin and gentamicin. The chemotherapeutic efficacy of quinoxidin and dioxidin was shown to be higher than that of carbenicillin and gentamicin with respect to both the bacteriological criteria and the pathomorphological indices.

[Comparative experimental study of cyclacillin and ampicillin].

Cyclacillin was compared with ampicillin by its bacteriostatic efficiency in vitro, chemotherapeutic efficiency in experimental infections of mice and rats and pharmacokinetic characteristics. It was found that cyclacillin was not superior to ampicillin by its antibacterial action. By a number of characteristics it was even significantly inferior.

[Comparative study of the antibacterial activity of a number of new antibiotics and their combinations in relation to Pseudomonas aeruginosa].

Tobramycin and sisomycin proved to have the highest antibacterial activity against 156 clinical strains of Ps. aeruginosa and were 4--8 times more effective than monomycin, kanamycin, neomycin and to a lesser extent gentamicin. The combination of mecillinam and sisomycin had a synergistic effect with respect to 26 out of 50 strains of Ps.

[Comparative study of the distribution of semisynthetic cephalosporins in the body of rats].

Distribution of 6 cephalosporin antibiotics, i. e. cephaloridin, cephalotin, cephradin cephacetryl, cephazolin and cephapyrin for parenteral use was studied comparatively on rats.

Production of Staphylococcus membranes and their enzymatic and protein characteristics.

Three methods of decomposition of Staphylococcus aureus 209-P cells were compared for the production of membranes-ultrasound, a press, and enzymatic lysis. All the tested methods permitted the isolation of enzymatically active membranes, differing somewhat in protein composition.

[Dioxidine in experimental pyocyanic pyelonephritis in rats].

A model of obturation hematogenous pyelonephritis was reproduced in rats by infecting them with Pseudomonas aeruginosa. On the model subject to study was chemotherapeutic activity of dioxidine (50--100 mg/kg per day) as compared to gentamycin (5 mg/kg per day). The drugs were administered intramuscularly for 7 days, starting 24 hours after inoculation of the animals.