Transporter associated with antigen processing and the chaperone tapasin: are non-classical HLA genes keys to the pathogenesis of schizophrenia?

Schizophrenia is a mind-destructive disease. Family and twin studies have indicated an equal contribution of genetic endowment and environmental factors in the pathogenesis of schizophrenia. Recently Chlamydiaceae species has been identified as a major factor in the pathogenesis of schizophrenia, suggesting defective immune responses of schizophrenic patients against this environmental factor.