Publications by authors named "Rudolf Pfeil"

Glyphosate is the most widely used herbicide worldwide. It is a broad spectrum herbicide and its agricultural uses increased considerably after the development of glyphosate-resistant genetically modified (GM) varieties. Since glyphosate was introduced in 1974, all regulatory assessments have established that glyphosate has low hazard potential to mammals, however, the International Agency for Research on Cancer (IARC) concluded in March 2015 that it is probably carcinogenic.

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Article Synopsis
  • Consumers ingest various pesticide residues through their diets, leading to EU regulations that assess both individual pesticide effects and their combinations, which poses a challenge for toxicology.
  • This study focuses on the additive effects of various antifungal (triazole) pesticides and other chemical class pesticides on hormone production in a human placental cell line, revealing pronounced inhibition of progesterone production with triazoles.
  • While triazoles and the fungicide prochloraz showed hormone-related effects, other pesticides like chlorpyrifos and triflusulfuron-methyl did not impact steroid hormone production or CYP enzyme expression significantly.
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This article summarizes the 7th Workshop on the Terminology in Developmental Toxicology held in Berlin, May 4-6, 2011. The series of Berlin Workshops has been mainly concerned with the harmonization of terminology and classification of fetal anomalies in developmental toxicity studies. The main topics of the 7th Workshop were knowledge on the fate of anomalies after birth, use of Version 2 terminology for maternal-fetal observations and non-routinely used species, reclassification of "grey zone" anomalies and categorization of fetal observations for human health risk assessment.

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This article is a report on the Fourth Berlin Workshop on Terminology in Developmental Toxicology, which was held in April 2002. The workshop is part of an international project in the field of harmonization of terminology in developmental toxicology supported by IPCS. The goal of the Harmonization Project is to ensure better chemical risk assessment.

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