- A 51-year-old male underwent adjuvant chemotherapy for rectal cancer, which included continuous 5-fluorouracil (5-FU) and he experienced chest pain shortly after starting treatment.
- Cardiac evaluation revealed reduced coronary flow and significant stenoses, leading to suspicion of acute coronary syndrome, but no immediate intervention was taken as the patient stabilized.
- After further monitoring, the patient's condition improved without significant complications, highlighting that continuous 5-FU may pose a higher risk for cardiac issues, necessitating close observation and prompt intervention if symptoms arise.
It was aimed to assess if intrathecal (i.t.) injections of acetylsalicylic acid and salicylic acid depress C fibre-evoked activity in the sensory part of the nociceptive system.