Publications by authors named "Rudnicka L"

: Minoxidil, in addition to its vasodilatory effect, has also immunomodulatory properties that may be partially responsible for its efficacy in alopecia areata. The aim of the study was to evaluate the efficacy of monotherapy with topical or oral minoxidil in alopecia areata. : A systematic review and meta-analysis of the efficacy of monotherapy with minoxidil in alopecia areata was conducted following the PRISMA guidelines.

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Background: Lichen planopilaris (LPP) is the most common form of scarring alopecia in adults. The disease may also occur in children and adolescents. The aim of this systematic review is to evaluate clinical, trichoscopic, and histopathologic features of pediatric LPP.

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  • The ALLEGRO studies show that ritlecitinib is effective and well-tolerated for treating alopecia areata in patients aged 12 and older for up to 24 months.
  • Results indicate significant improvement in hair regrowth, with a marked increase in patients achieving favorable Severity of Alopecia Tool (SALT) scores at both 12 and 24 months.
  • The safety profile of ritlecitinib remains consistent with previous studies, confirming its long-term tolerability for users.
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Background: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Due to its high prevalence, considerable morbidity, and chronicity, there is a need for the accurate in vivo evaluation of treatment efficacy. Line-field confocal optical coherence tomography (LC-OCT) is a new emerging imaging technique able to perform a non-invasive, real-time examination of the epidermis and the upper dermis.

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  • * Persistent benign lesions like genital warts are common, and there's currently no drug to stop HPV replication; treatment mainly focuses on removing lesions and boosting immune response.
  • * The paper explores HPV systematics, its pathogenic mechanisms, especially the role of viral proteins E6 and E7, and discusses future treatment prospects, including new inhibitors and therapeutic vaccines.
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  • Onychoscopy is a non-invasive technique used to better diagnose nail disorders like nail psoriasis and lichen planus, providing detailed visual insights beyond a standard clinical examination.
  • In nail psoriasis, key onychoscopic features include pitting, onycholysis with a red border, and specific patterns like salmon patches, while nail lichen planus shows signs like onychorrhexis and longitudinal melanonychia.
  • There is limited literature on the use of onychoscopy for nail lichen striatus, and the features observed can vary between fingernails and toenails.
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  • Frontal fibrosing alopecia (FFA) is a type of hair loss marked by receding hairlines, itching, and small facial bumps, with many treatments available but some symptoms proving hard to treat.
  • A review of 12 studies found that oral isotretinoin may significantly improve treatment-resistant facial papules in FFA patients, although the current evidence comes mainly from retrospective studies and case reports.
  • The findings suggest that isotretinoin could be a beneficial treatment option, but more rigorous research is needed to confirm its effectiveness.
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Background: There is limited insight into the current disease burden and everyday clinical management of moderate-to- severe AD in Poland, Czechia, Russia, and Turkiye. Therefore, this study aimed to get information-driven insights regarding the current disease burden and clinical management of patients with moderate-to-severe AD with common and differentiating aspects of the patient journey and establish a consensus.

Methods: In this modified 2-round Delphi panel, 133 questions were asked in total to 27 dermatologists.

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Introduction: Diagnosis of persistent erythematous, scaly patches, or plaques can be complex since psoriasis (Ps), eczematous dermatitis (ED), and mycosis fungoides (MF) can be considered. Dermoscopy, which is a noninvasive diagnostic tool, is commonly used to examine blood vessels, scales, and background color; however, research on hair shaft evaluation in inflammatory dermatoses remains scarce. The aim of the study was dermoscopic evaluation of hair shafts in skin lesions localized on the non-scalp skin areas in patients diagnosed with MF, Ps, and ED.

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Objectives: This study aims to update the understanding of Alopecia Areata (AA) in Poland, Czechia, Russia, and Türkiye, focusing on the disease burden, clinical management, and patient journey. It seeks to establish a consensus on optimal management strategies for AA in these regions.

Methods: A modified 2-round Delphi panel was conveyed with 23 Dermatologists (Russia; 4, Türkiye; 7, Poland; 6, and Czechia; 6).

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  • Oligodontia, a condition where a person is missing several teeth, can occur on its own or as part of a syndrome linked to other issues affecting the skin, hair, or nails.
  • The study examined hair characteristics of 25 orthodontic patients aged 6 to 24 who were diagnosed with oligodontia but showed few ectodermal symptoms.
  • Results showed a significant prevalence of hair disorders in 68% of subjects, including various forms of hair loss and texture abnormalities, suggesting that hair examination methods like trichoscopy and trichogram could help distinguish between types of oligodontia.
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: Androgenetic alopecia, the most common cause of non-scarring hair loss, is a consequence of the gradual miniaturization of the hair follicles. In the majority of male androgenetic alopecia cases, a patient's history and clinical evaluation may be sufficient to establish the diagnosis, while for women, they should be supplemented with trichoscopy. : The PubMed and Scopus databases were used to collate published studies and to analyze the most typical trichoscopic findings in patients diagnosed with androgenetic alopecia.

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Introduction: Pediatric androgenetic alopecia is a product of hormonal and genetic factors. The diagnosis depends on recognizing the hair loss pattern in the context of a positive family history and a typical trichoscopy.

Methods: A multicenter retrospective study assessing medical data from January 2008 to January 2023 of two reference centers - one public and one private in west Mexico.

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Trial Design: Pemphigus is a rare but life-threatening autoimmune disease requiring long-term treatment that minimizes corticosteroid (CS) exposure while providing consistent disease control. The phase 2 pemphigus study of oral, reversible, covalent Bruton tyrosine kinase inhibitor rilzabrutinib demonstrated rapid and sustained efficacy with well-tolerated safety.

Methods: Adults (aged 18-80 years) were randomized 1:1 to 400 mg rilzabrutinib (n = 65) or placebo (n = 66) twice daily (with CS ≤ 0.

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The term 'sclerosing diseases of the skin' comprises specific dermatological entities, which have fibrotic changes of the skin in common. These diseases mostly manifest in different clinical subtypes according to cutaneous and extracutaneous involvement and can sometimes be difficult to distinguish from each other. The present consensus provides an update to the 2017 European Dermatology Forum Guidelines, focusing on characteristic clinical and histopathological features, diagnostic scores and the serum autoantibodies most useful for differential diagnosis.

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The term 'sclerosing diseases of the skin' comprises specific dermatological entities, which have fibrotic changes of the skin in common. These diseases mostly manifest in different clinical subtypes according to cutaneous and extracutaneous involvement and can sometimes be difficult to distinguish from each other. The present consensus provides an update to the 2017 European Dermatology Forum Guidelines, focusing on characteristic clinical and histopathological features, diagnostic scores and the serum autoantibodies most useful for differential diagnosis.

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Importance: Current measures of alopecia areata (AA) severity, such as the Severity of Alopecia Tool score, do not adequately capture overall disease impact.

Objective: To explore factors associated with AA severity beyond scalp hair loss, and to support the development of the Alopecia Areata Severity and Morbidity Index (ASAMI).

Evidence Review: A total of 74 hair and scalp disorder specialists from multiple continents were invited to participate in an eDelphi project consisting of 3 survey rounds.

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  • * A safety analysis of four studies showed that adverse events (AEs) occurred in about 70-75% of patients on ritlecitinib compared to 69.5% in the placebo group, with some patients experiencing serious AEs.
  • * Overall, ritlecitinib is deemed well tolerated and presents an acceptable safety profile over a 24-month period for adolescents and adults with AA.
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Background: Positron-emission tomography (PET) is widely used for staging lung cancer. Although a correlation between the fluorodeoxyglucose standardized uptake value (SUV) and the histologic grade of the tumor has been shown in several studies, little is known about the impact of different clinical variables on this correlation. This study aimed to evaluate the correlation between tumor SUV and tumor grade in a large cohort of patients and to analyse the impact of clinical factors on this correlation.

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