Publications by authors named "Rudmer Postma"
COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily manifests as a flu-like illness with lung injury, often necessitating supplemental oxygen. Elderly individuals and those with pre-existing cardiovascular diseases are at increased risk of mortality. The endothelial barrier disruption observed in patients indicates systemic viral invasion and widespread endotheliitis.
View Article and Find Full Text PDFBackground: Systemic diseases are often associated with endothelial cell (EC) dysfunction. A key function of ECs is to maintain the barrier between the blood and the interstitial space. The integrity of the endothelial cell barrier is maintained by VE-Cadherin homophilic interactions between adjacent cells.
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- Cancer increases the risk of venous thromboembolism, particularly in glioblastoma cases, highlighting the need for new models to study this issue at a molecular level.
- A novel cancer-on-a-chip model was created to analyze how glioblastoma cells affect blood coagulation by co-culturing glioblastoma spheroids with endothelial cells.
- Results showed that glioblastoma cells significantly heightened blood coagulation, and using anticoagulant drugs like rivaroxaban effectively reduced this coagulation in the model, suggesting its potential for discovering new anticoagulant therapies for glioblastoma and similar cancers.
Background And Aims: Endothelial cell (EC) dysfunction in response to circulating plasma factors is a known causal factor in many systemic diseases. However, no appropriate assay is available to investigate this causality . In liver cirrhosis, systemic inflammation is identified as central mechanism in progression from compensated to decompensated cirrhosis (DC), but the role of ECs therein is unknown.
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- Disturbed flow contributes to endothelial dysfunction in intimal hyperplasia, commonly found in vascular grafts, leading to adverse vascular conditions.
- This study introduces a new bypass flow model that simulates disturbed flow and various hemodynamic patterns using pulsatile flow.
- Using computational fluid dynamics (CFD), researchers validated the model by showing that human endothelial cells exposed to disturbed flow exhibited significant changes in morphology and activation compared to cells in regular or stagnant flow, highlighting the model's potential for studying vascular diseases.
G protein-coupled receptors (GPCR) are involved in various physiological and pathophysiological processes. Functional autoantibodies targeting GPCRs have been associated with multiple disease manifestations in this context. Here we summarize and discuss the relevant findings and concepts presented in the biennial International Meeting on autoantibodies targeting GPCRs (the 4th Symposium), held in Lübeck, Germany, 15-16 September 2022.
View Article and Find Full Text PDFBesides hyperlipidemia, inflammation is an important determinant in the initiation and the progression of atherosclerosis. As Neuroimmune Guidance Cues (NGCs) are emerging as regulators of atherosclerosis, we set out to investigate the expression and function of inflammation-regulated NGCs. NGC expression in human monocytes and endothelial cells was assessed using a publicly available RNA dataset.
View Article and Find Full Text PDFBackground: Migraine is a common episodic brain disorder. Treatment options and diagnosis are hampered by an incomplete understanding of disease pathophysiology and the lack of objective diagnostic markers. The aim of this study was to identify biochemical differences characteristic for different subtypes of migraine in cerebrospinal fluid (CSF) of migraine patients using an exploratory H-NMR-based metabolomics approach.
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